Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 24Periodontal Regeneration and TreatmentsDental Implant Techniques and OutcomesBone Tissue Engineering Materials

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

TGF-β1 and BMP-4 carried by liposomes enhance the healing process in alveolar bone

Ferreira, Cynthia Lopes, Abreu, Fernando Antônio Mauad de, Silva, Gerluza Aparecida Borges, Silveira, Frank Ferreira, Barreto, Luana Beatriz Araújo, Paulino, Tony de Paiva, Miziara, Melissa Nunes, Alves, José Bento·2013·Archives of Oral Biology
DOI 10.1016/j.archoralbio.2012.11.013
Open this paper in CoChat — free account

Abstract

Objective In this work we evaluated the bone-forming potential of BMP4, TGFβ1 and BMP4/TGFβ1 mixed by performing histological and morphometric analysis. We also evaluated the immunolabelling of fibronectin (FN) and collagen type III (Col III), two determinant proteins for the early phase of bone repair. Design Histological, histomorphometric and immunohistochemistry analysis were used to evaluate new bone and blood vessels formation as well as fibronectin and collagen type III expression. 112 male Wistar rats weighing 250-300g had their maxillary second molar extracted. Sockets filled with blood clot (BC) or treated with L (empty liposome), P (PBS), BP (BMP-4 in PBS) and TP (TGF-β1 in PBS), as well as with BL (BMP-4 in liposome) and TL (TGF-β1 in liposome) administered isolated or in association (BTL) were obtained. The animals were sacrificed at 3, 7, 14 and 21 days after surgery. Results An increased percentage of bone trabeculae, and a higher number of blood vessels were observed in groups BL or TL administered isolated or in association when compared to groups BC, L, P, BP and TP. Fibronectin and collagen type III analysis revealed enhanced expression firstly detected at 3 days followed by a peak at 7 days. Lower levels of immunoreactivity were observed in the sockets filled with blood clot, and treated with L, P, BP and TP when compared with sockets from groups BL, TL and BTL. Conclusion The present study indicates growth factors carried by liposomes, either in isolated or associated forms, as successful enhancers of the healing process in rat tooth sockets. We also conclude that the expression of fibronectin and collagen type III increases during the early phases of bone repair.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.archoralbio.2012.11.013

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Friedlaender, 2001, Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions, Journal of Bone and Joint Surgery, 83-A, S151

Cited by

See all 24

Metadata

Authors
Ferreira, C. L., Abreu, F. A. M. D., Silva, G. A. B., Silveira, F. F., Barreto, L. B. A., Paulino, T. D. P., Miziara, M. N., & Alves, J. B.
Affiliations
  • Universidade Federal de Minas Gerais (BR)
  • Pontifícia Universidade Católica de Minas Gerais (BR)
  • Universidade de Uberaba (BR)
Corresponding author
Alves, José Bento
ORCID
Venue
Archives of Oral Biology
Publisher
Elsevier BV
Published
2013-06
Volume
58
Issue
6
Pages
646-656
ISSN
0003-9969 (ISSN-L)
DOI
10.1016/j.archoralbio.2012.11.013
OpenAlex
W2034872463
Cited by
24
References
73
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1
FWCI
2.01
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Oral Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
TGF-β1, BMP4, liposomes, bone regeneration, alveolar bone healing, extraction sockets, bone morphogenetic proteins, fibronectin, type III collagen, angiogenesis, growth factor delivery
MeSH terms
Alveolar Process, Animals, Blood Coagulation, Drug Carriers, Fibronectins, Liposomes, Male, Maxilla, Osteoblasts, Osteoclasts, Osteogenesis, Random Allocation, Time Factors, Tooth Extraction, Wound Healing, Rats, Wistar, Neovascularization, Physiologic, Tooth Socket, Collagen Type III, Rats, Transforming Growth Factor beta1, Bone Morphogenetic Protein 4

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.