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Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

Open access
Lee, Kangwon, Silva, Eduardo A., Mooney, David J.·2011·Journal of The Royal Society Interface

Abstract

The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.

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Crossref · 10.1098/rsif.2010.0223

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Metadata

Authors
Lee, K., Silva, E. A., & Mooney, D. J.
Venue
Journal of The Royal Society Interface
Published
2010-08-18
Volume
8
Issue
55
Pages
153-170
ISSN
  • 1742-5662 (ISSN-L)
  • 1742-5689
OpenAlex
W2129358933
Cited by
1,386
References
8
FWCI
51.85
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. https://app.cochat.ai/papers/10.1098/rsif.2010.0223
The paper
Lee, K., Silva, E. A., & Mooney, D. J. (2011). Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. Journal of The Royal Society Interface. https://doi.org/10.1098/rsif.2010.0223

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.