AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

Salminen, Antero, Kaarniranta, Kai·2012·Ageing Research Reviews

DOI 10.1016/j.arr.2011.12.005

Cited by (860)

Items 701–800 of 860

cIAP-2 Expression Increases in Elderly Patients with Squamous Cell Carcinoma of the Head and Neck
Chi‐Long Chen, Chun-Yi Chiang, Kuang‐Wen Liao, Shu-Yi Ho, Yi-Fang Chang, Ken‐Hong Lim, Ruey‐Kuen Hsieh, Yu‐Ling Lin, Ying-Wen Su · 2017 · International journal of gerontology
Protein Metabolism in the Elderly
E. Lichar Dillon · 2016 · Elsevier eBooks
Sirtuins in bone and cartilage biology
Kazuo Yudoh, Naoko Yui, K. Terauchi, Hajime Kobayashi, Takanori Kumai, Shu Somemura · 2021 · Elsevier eBooks
Does strawberry supplementation ameliorate markers of cardiovascular and metabolic health? A systematic review and meta-analysis
Reihaneh Mousavi, Morteza Arab‐Zozani, Elaheh Foroumandi, Majid Karandish, Leila Maghsoumi‐Norouzabad, Anahita Mansoori, Jalal Moludi · 2021 · Nutrition & Food Science
Inflammaging Signaling in Health Span and Life Span Regulation
Antero Salminen, Anu Kauppinen, Kai Kaarniranta · 2013 · Elsevier eBooks
Autophagy activation as a mechanism of action of psychoactive drugs, revised and expanded version
Dennis F. Mangan · 2015
Contribution of Insulin Resistance in Pathogenesis of Alzheimer Disease
Adnan Erol · 2013
SignalingProfiler 2.0: a network-based approach to bridge multi-omics data to phenotypic hallmarks
Veronica Venafra, Francesca Sacco, Livia Perfetto · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Effects of Sirtuins on Female Reproductivity and Oocyte Quality: Traditional Review
Esra ŞEN, Hakkı Dalçık, Cannur Dalçık · 2022 · Turkiye Klinikleri Journal of Medical Sciences
Protein kinase modulation for anti-aging intervention
Mario F. Muñoz, Sandro Argüelles, Antonio Ayala, Francesco Marotta · 2023 · Elsevier eBooks
White Paper on Nutrition Sensing and Ageing
Aygul Dagbasi, Adrian Holliday, Bernadette Carroll, Chiara de Lucia, Oliver Michael Shannon, John Cummings Mathers, John T. McLaughlin, Chloe French, Aylin Carla Hanyaloglu, Sorrel T. Burden et al. · 2025 · Nutrition Bulletin
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
Ying Yang, Da Eun Kang, Qi Fan, Eric Allan Hanse, Hosung Bae, Rocio A. Barahona, Xiyu Shen, Bryan I. Ruiz, Saiho Lee, Katherine R. Pasterczyk et al. · 2025 · Science Advances
Molecular mechanisms of metformin action: From metabolic effects to lifespan extension and healthspan promotion
Slavica Vujović, Svetlana Perović, Milorad Vlaović, Stasa SCEPANOVIC, Aleksandra Filipović · 2025 · Journal of Medical Biochemistry
Genetics of Aging and Life Span: Molecular Mechanisms and Intervention Prospects
Alexey Moskalev · 2025 · Russian Journal of Genetics
Effects of collagen tripeptide supplementation on oxidative stress and mitochondrial function in aging
Chae-Eun Kim, Joong Su Lee, Yun-Ho Kim, Yong Chul Shin, Su‐Kyung Shin, Eun‐Young Kwon · 2025 · Nutrition Research and Practice
Discovery of Novel MDH2 Inhibitor 28i by Secondary Development of Glibenclamide with Potent Antiaging Activities
Lingyu Wu, Ru Zeng, Shuman Huang, Jiale Wu, Yu Ai, Zhifan Mao, Zhiguo Yang, Dan Liu, Yi-You Huang, Jian Li et al. · 2026 · Journal of Medicinal Chemistry
Chondrocyte-targeting hydrogel loaded with puerarin limits osteoarthritis development by maintaining mitochondrial function
Yunpeng Wan, Kai Shen, Jishi Jiang, Dan Li, Mingming Ma, Chengmin Liang, Jie Cao, Bin Liu, Yu Ge, Lei Li et al. · 2026 · Chemical Engineering Journal
Dietary strategies to counter obesity-accelerated aging: Enhancing health-span and longevity
Polu Picheswara Rao · 2026 · Obesity Medicine
The metabolic-inflammatory axis in aging: A multi-organ framework anchored in Sarcopenia — A review
Tian Liang · 2026 · Archives of Gerontology and Geriatrics
Dual Single‐Atom Engineered NADH Oxidase‐Mimic Boosts In Situ NAD + Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection
Jingtao Liu, Xun Guo, Nan Wang, Xingyu Zhang, Xiaoting Wang, Guangru Li, Xumin Hou, Luodan Yu, Yu Chen, Ruogu Li · 2026 · Advanced Materials
Multi-pathway and gut microbiota mechanisms underlying the antioxidant effects of formononetin
薛梅, Lingrui Kong, Yan Chen, Lin Hou, Jian Hou · 2026 · South African Journal of Botany
Targeting NLRP3 inflammasome to mitigate chemotherapy-induced cardiotoxicity: advances in selective inhibitors and natural modulators
Dipil Dhondsekar, Satish Mandlik, Deepa Mandlik · 2026 · Molecular Biology Reports
Nicotinamide N-methyltransferase as a stress-responsive metabolic-epigenetic regulator of tubular senescence in chronic kidney disease
An Liu, Xiaojuan Zhu, Wei-Dong Sun, Shuang-Zhou Bi, Chen‐Ying Zhang, J N Li · 2026 · Cellular Signalling
A senescent metabolism-modulating hierarchical scaffold restores NAD+ homeostasis and redox balance for aged bone repair
Jia Jiang, Jiajie Chen, Xiao Wang, Xinxin Zhang, Hongxu Lv, Chengtie Wu, Lei Han, Yufang Zhu · 2026 · Bioactive Materials
A dual-engineered chondrocyte-targeting tetrahedral DNA-based nanoparticle for improved delivery of metformin and alleviation in osteoarthritis
Qi Han, Qi Han, Hao Deng, Alimire Alifu, Jie Li, Zhuo Chen, Linlin Deng, Xiaoxiao Cai, Yu Chen, Yunfeng Lin · 2026 · Biomaterials
Metformin at the convergence of aging and longevity
Jarra Manneh, May Alasmar, Nady El Hajj · 2026 · Aging
Anti-Aging Drugs
Alexander M. Vaiserman · 2016 · Elsevier eBooks
Environmental and Physiological Cues on the Hypothalamus During Aging
Jan Olof Nehlin · 2017 · Healthy ageing and longevity
Age-related expression of prominent regulatory elements in mouse brain: catastrophic decline of FOXO3a
C. David Rollo, Susan E. Marsh‐Rollo, Douglas R. Boreham, Jennifer A. Lemon · 2021 · GeroScience
Antiaging Strategies Based on Sirtuin Activation
Geetika Garg, Sandeep Singh · 2023 · Springer eBooks
Vutiglabridin exerts anti-ageing effects in aged mice through alleviating age-related metabolic dysfunctions
Jooseung Hyeon, Jihan Lee, Eunju Kim, Hyeong Min Lee, Kwang Pyo Kim, Jaejin Shin, Hyung Soon Park, Yun‐Il Lee, Chang‐Hoon Nam · 2023 · Experimental Gerontology
DNA Damage, Transposable Element Expression and Their Associated Factors in Aging
Temesgen Mitiku, Betelhem Abebe, Nega Birhane, Birhan Getie · 2024 · Biochemistry and Molecular Biology
Sarcopenia in independent oldest-old individuals treated for diabetes, with or without metformin: a case–control study
Maísa Braga Aguiar, Solomon Kim, Adriana Bruscato Bortoluzzo, Ana Beatriz Galhardi Di Tommaso, Maysa Seabra Cendoroglo, Gisele W. B. Colleoni · 2025 · Acta Diabetologica
Nutrition in the Elderly
Eugenio Mocchegiani · 2016 · Elsevier eBooks
EET Intervention on HO-1 Prevent Obesity Derived Cardiovascular Diseases
Lu Liu, Xin Huang, Jin-Liao Gao, Yusong Guo, Yanqi Di, Shasha Sun, Jian Cao · 2018 · Journal of Biomolecular Research & Therapeutics
HO-1-derived CO Is a Regulator of Vascular Function and Metabolic Syndrome
Joseph Schragenheim, Omri Maayan, Nader G. Abraham · 2018 · Royal Society of Chemistry eBooks
Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins
Hajira Ramlan, Hanafi Ahmad Damanhuri · 2019 · Experimental Gerontology
Fermentation broth of Serpula similis protect cells from oxidative stress-induced senescence via AMPK-dependent autophagy restoration
Chen Cui, Min Zhou, Yuchen Ge, Hui Hua, Xiaojian Wu, Xiaobo Wang · 2022 · Pharmacological Research - Modern Chinese Medicine
Mechanisms involved in prevention of dementia and promotion of healthy aging by resveratrol
Brahm Kumar Tiwari, Kanti Bhooshan Pandey · 2022 · Elsevier eBooks
Regulation of NRF2 signaling pathway and the hallmarks of aging: An overview
Alessandro Medoro, Giovanni Scapagnini, Sergio Davinelli · 2023 · Elsevier eBooks
The role of resveratrol treatment and regular physical activity on sirtuins in brain of rats artificially selected for intrinsic aerobic running capacity
Linda Szűcs · 2015 · REAL-PhD (Hungarian Academy of Sciences)
Exploring Redox Biology in physiology and disease
Anne M. Koning · 2017 · University of Groningen research database (University of Groningen / Centre for Information Technology)
Food odors decrease longevity via a brain–gut axis
Kaiden H. Price, Michael N. Nitabach · 2021 · Nature Aging
Hemin decreases cellular aging and enhances healthspan and lifespan through the AMPK pathway
Yizhong Zhang, Arshia Naaz, Nashrul Afiq Faidzinn, Sonia Yogasundaram, Trishia Yi Ning Cheng, Jovian Lin Jing, Ingrid Wen-Hui Jeanette Morel Gan, Junqi Chen, Mohammad Alfatah · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
AMP accumulation during mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180
Avijit Mallick, Theresa Raquel de Oliveira Ramalho, Yunguang Du, Rui Li, Levi D. Ali, Sookyung Kim, Pooja Rai, Andreas Bergmann, Lihua Julie Zhu, Cole M. Haynes · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Advanced therapy medicinal products: Gene therapy
Antonio Ayala, Mario Muñoz, Sandro Argüelles, Francisco Zurita, Mercedes Cano · 2015 · Pharmaceuticals Policy and Law
Calcium/Calmodulin dependent protein kinase II signaling and IGFR signaling are courter-balanced to regulate protein degradation in C. elegans muscle
Caitlin Feather · 2013
AMP‐Activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection
Petronela Weisová, Shona Pfeiffer, Jochen H.M. Prehn · 2015 · Wiley eBooks
Caenorhabditis elegans as a research tool to study mitochondrial diseases associated with defects in tRNA modification
MARÍA DEL CARMEN NAVARRO GONZÁLEZ · 2016
The Effects of the Immunity Factor Relish on Aging Phenotypes in Drosophila melanogaster
Nandita Kumar · 2016
Aging-Related Diseases and Autophagy
Elif Damla Arısan, Pınar Obakan Yerlikaya, Ajda Çoker Gürkan, Narçın Palavan-Ünsal · 2016 · InTech eBooks
Effects of AMP-activated kinase modulators on intracellular Ca2+ signalling and C. elegans lifespan
Jessica Arias-del-Val · 2018
Autophagy Dysregulation in Alzheimer’s Disease: Plant Polyphenols as A Possible Preventive and Therapeutic Treatment.
Manuela Leri, Monica Bucciantini, Massimo Stefani · 2019 · Florence Research (University of Florence)
Eating Habits and Their Impact on Aging and Cancer
Fabio Marongiu, Monica Serra, Ezio Laconi · 2019 · Royal Society of Chemistry eBooks
Regenerative Medicine and Ageing
Michael D. West · 2020 · Elsevier eBooks
Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 2
Khara Lucius · 2020 · Alternative and Complementary Therapies
Type 2 Diabetes Mellitus in Osteoarthritic Patients: Does Association Between Metabolic Impairments, Joint Destruction, and Pain Exist?
Elena Vasilyevna Chetina, Galina A. Markova, E. P. Sharapova · 2020 · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry
Reatividade vascular e influência do tecido adiposo perivascular (PVAT) no modelo de envelhecimento SAMP-8.
Paula R. Barros · 2020
Role of Phytomolecules on the Basic Biology of Aging
Swapnil Pandey, Puneet Singh Chauhan · 2021 · Springer eBooks
Math and the Fountain of Youth
Mehrshad Sadria · 2020 · UWSpace (University of Waterloo)
Corrigendum: Searching for the Mechanisms of Mammalian Cellular Aging Through Underlying Gene Regulatory Networks
Wenbo Li, Lei Zhao, Jin Wang · 2021 · Frontiers in Genetics
Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression
Poonam Bheda · 2021 · Elsevier eBooks
The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
Dennis M. Minton · 2020 · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Влияние ограничения питания на старение: исправление проблем с «сенсорами питания» у постмитотических клеток?
Моргунова Галина Васильевна, Г.А. Шиловский, Alexander N. Khokhlov · 2021 · Biochemistry (Moscow)
Ageing process and policosanol effects
José Illnait-Ferrer, Julio César Fernández-Travieso, Yenney Reyes Nuñez, Alicia de la Caridad Duquesne-Chávez · 2021 · World Journal of Advanced Research and Reviews
Bacterial community and composition of soil in world’s longevity township Jiaoling, China by 16S rRNA high-throughput sequencing
Lei Wu, Xinqiang Xie, Jun Ma, Jumei Zhang, Yu Xian Ding, Qingping Wu · 2021 · Research Square
Aging Is a Determinant in Anoxia Stress Tolerance in Caenorhabditis Elegans
Jo M. Goy · 2013
Multi-omic analysis of the aging mouse brain
Verena Kluever · 2021
Fermentation Broth of Serpula Similis Protect Cells from Oxidative Stress-Induced Senescence Via AMPK-Dependent Autophagy Restoration
Cui Chen, Min Zhou, Yuchen Ge, Hui Hua, Xiaojian Wu, Xiaobo Wang · 2021 · SSRN Electronic Journal
Potencial neurotrófico e neuroprotetor do fitoquímico carvacrol contra a neurotoxicidade induzida pela acroleína em células PC12
F Sisti · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
Faculty Opinions recommendation of Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Dieter A Wolf, Meera Shah · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of Metformin reverses established lung fibrosis in a bleomycin model.
Vassilis Aidinis, Christiana Magkrioti · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Enhanced mitochondrial biogenesis promotes neuroprotection in human stem cell derived retinal ganglion cells of the central nervous system
Michelle L. Surma, Kavitha Anbarasu, Sayanta Dutta, Leonardo J. Olivera Perez, Kang-Chieh Huang, Jason S. Meyer, Arupratan Das · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Disrupted cellular quality control mechanisms in aging
Cristina Carvalho, Joana F. Pires, Paula Isabel Moreira, Nuno Raimundo · 2022 · Elsevier eBooks
OR2H2 Activation Suppresses Cellular Senescence and Aging by Activating AMPK and Inducing Senolysis in VK2/E6E7 Cells
Ji Min Kim, Sina Dziobaka, Ye Eun Yoon, Ha Lim Lee, Ji Hyun Jeong, In-Ryeong Lee, Daniel Weidinger, Changwon Yang, Deokho Kim, Gulperi Yalcin et al. · 2022 · Research Square
Novel Strategies for Metformin as an Anti-aging Drug in Skin Aging
Gonul Kanigur-Sultuybek, Tuğba Soydaş · 2023 · Springer eBooks
The Osteoarthritis-Associated Catabolic Factor, Interleukin-1β, Down Regulates Chondrocyte Energy Metabolism by Modulating Adenosine Monophosphate-Activated Protein Kinase in OA
Kazuo Yudoh, Naoko Yui, Takanori Kumai, Hajime Kobayashi, Kamada Toshikazu, Hiroto Fujiya, 木城智, Kenji Uehara, Hisateru Niki · 2018
The Role of C-reactive Protein in Aging associated NAFLD
Zheng Ding, Yuqiu Wei, Jing Peng, Siyu Wang, Guixi Chen, Jiazeng Sun · 2023 · Preprints.org
Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism
Wenning Lan, Xiaolian Xiao, Xiaojing Zhang, Jingjing Nian, Ziran Wang, Yajiao Wu, Dongcheng Zhang, Junkun Chen, Wenqiang Bao, Chutao Li et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Time-series analysis of hematopoietic stem cells
Jingjing Han, Shuangshuang Duan, Ya Li, Chunlei Xin · 2024 · Medicine
The role of Banf1 in mechanisms of cellular ageing and cancer prognosis
Jennifer Plowman · 2024 · Queensland University of Technology
Stromal mediated DNA damage promotes high grade serous ovarian cancer initiation
Geyon L. Garcia, Taylor J. Orellana, Grace Gorecki, Leonard G. Frisbie, Roja Baruwal, Ester Goldfield, Ian Beddows, Ian MacFawn, Ananya K. Britt, Macy M. Hale et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral Synucleinopathy
Lin Lin, Nanna Møller Jensen, Sara Almeida Ferreira, Alberto Delaidelli, Diana Gomes Moreira, Ole Andreas Ahlgreen, Mette Richner, Poul H. B. Sorensen, Marina Romero‐Ramos, Christian Bjerggaard Vægter et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Interaction of three weeks HIIT and vitamin D supplementation on some oxidant and inflammatory factors in heart tissue of middle-aged rats
Farhoodi Moghadam ., Nika Soltani, Fereshteh Shahidi, Fatemeh Nourzad · 2024 · Comparative Exercise Physiology
Oxidative Stress in Aging
Abderrezak Khelfi · 2024 · Springer eBooks
Repurposing metformin: A potential off‐label indication for ischaemic stroke?
Thura Tun Oo · 2024 · Diabetes Obesity and Metabolism
Exploring the Plasma Proteome: Identifying Hub Proteins linking Aging, Homeostasis, and Organ Function
Juan Jiao, Fei Gao, Hong‐Ye Zhao, Mingjun Jiang, Yan Hong Zhou, Dizhi Liu, Sihang Fang, Danni Gao, Zhaoping Wang, Ze Yang et al. · 2025 · International Journal of Medical Sciences
Assessment of the Capability of Mesenchymal Stem Cells and/or Pyrroloquinoline Quinone in Compensating the Age-Related Dysfunctions of AMP-Activated Protein Kinase Pathway in Wistar Rats
Kamal M. Al Nishilli, Emad El Zayat, Sherein Saied. Abdelgayed, Mohamed Hosney, Nourhan Hassan · 2025 · Cell Biochemistry and Biophysics
Identification and Analysis of Exercise-Related Gene Biomarkers in Sarcopenia
Shanshan Yu, Meishi Wang, Sensen Zhao, Zhaoli Zhou · 2024 · International Congress on Image and Signal Processing (CISP)
JNK Acts as A Conserved Regulator Prevents Healthy Aging by Attenuating Proteostasis Stress During Aging
Dan Xu, Wenxiang Yi, Haiying Fu, Ting Chen, Jurui Yu, Yiqiang Zhi, Jingjing Lin, Zhiheng Xu · 2025 · Research Square
Decoupling AMPK from fatty acid synthesis allows maintenance of fitness late in life
Hanane Hadj‐Moussa, Megan Ulusan, Dorottya Horkai, Mohammed Kamran Afzal Mirza, Jonathan M. Houseley · 2026 · eLife
Dissecting Metabolic Control of Behaviors and Physiology During Aging in Drosophila
Elizabeth S. Pasam, Kishore Madhamanchi, Girish Chandra Melkani · 2025 · Research Square
Identification of the changes of immune response, morphology, and gene expressions in hepatopancreas of Macrobrachium nipponense under the treatment of alkalinity exposure
Shubo Jin, Hongtuo Fu, Yiwei Xiong, Hui Qiao, Wenyi Zhang, Sufei Jiang · 2025 · Comparative Biochemistry and Physiology Part D Genomics and Proteomics
Placental gene expression of the AMPK signaling pathway in association with gestational exposure to ambient air pollution
Joline L Millen, Dries S. Martens, Rossella Alfano, Theo M. C. M. de Kok, Michelle Plusquin, Florence Debacq‐Chainiaux, Thierry Arnould, Tim S. Nawrot · 2025 · Environmental Research
Metabolic health and intermittent fasting: implications for age-related disorders
Shampa Ghosh, Dr. Krishna Kumar Singh, Manchala Raghunath, Jitendra Kumar Sinha · 2025 · Elsevier eBooks
Autophagy as mechanism of action of psychoactive drugs
P. D. Mangan · 2015 · The Winnower
Additional file 2 of Effects and associated transcriptomic landscape changes of methamphetamine on immune cells
Deshenyue Kong, Mao, Jun-Hong, Li, Hong, Wang, Jian-Yu, Li, Yu-Yang, Wu, Xiao-Cong, Re, Guo-Fen, Luo, Hua-You, Kuang, Yi-Qun, Wang, Kun-Hua · 2022 · Figshare
Additional file 3 of Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
Cheng, Demin, Xu, Qi, Wang, Yue, Li, Guanru, Sun, Wenqing, Ma, Dongyu, Zhou, Siyun, Liu, Yi, Han, Lei, Ni, Chunhui · 2021 · Figshare
Additional file 1 of Effects and associated transcriptomic landscape changes of methamphetamine on immune cells
Deshenyue Kong, Mao, Jun-Hong, Li, Hong, Wang, Jian-Yu, Li, Yu-Yang, Wu, Xiao-Cong, Guo-Fen Re, Luo, Hua-You, Kuang, Yi-Qun, Wang, Kun-Hua · 2022 · Figshare
Additional file 2 of Metformin attenuates silica-induced pulmonary fibrosis via AMPK signaling
Cheng, Demin, Xu, Qi, Wang, Yue, Li, Guanru, Sun, Wenqing, Ma, Dongyu, Zhou, Siyun, Liu, Yi, Han, Lei, Ni, Chunhui · 2021 · Figshare