AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
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- AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult miceSheng Zhou, Wanli Lu, Chen Liang, Qiting Ge, Dongyang Chen, Zhihong Xu, Dongquan Shi, Jin Ming Dai, Jianxin Li, Huangxian Ju et al. · 2017 · Scientific Reports
- Hypoxia-induced transcription factor signaling is essential for larval growth of the mosquito Aedes aegyptiLuca Valzania, Kerri L. Coon, Kevin J. Vogel, Mark R. Brown, Michael R. Strand · 2018 · Proceedings of the National Academy of Sciences
- The Impact of Glucose-Lowering Drugs on Sarcopenia in Type 2 Diabetes: Current Evidence and Underlying MechanismsElena Massimino, Anna Cecilia Izzo, Gabriele Riccardi, Giuseppe Della Pepa · 2021 · Cells
- Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed MiceXiaoqin Ding, Tunyu Jian, Jiawei Li, Han Lv, Bei Tong, Jing Li, Xiuhua Meng, Bingru Ren, Jian Chen · 2020 · Oxidative Medicine and Cellular Longevity
- Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell StressRafah Mackeh, Séverine Lorin, Ameetha Ratier, Najet Mejdoubi‐Charef, Anita Baillet, Arnaud Bruneel, Ahmed Hamaï, Patrice Codogno, Christian Poüs, Daniel Perdiz · 2014 · Journal of Biological Chemistry
- Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytesFreyr Petursson, Matt Husa, Ronald K. June, Martin Lotz, Robert A. Terkeltaub, Ru Liu‐Bryan · 2013 · Arthritis Research & Therapy
- AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functionsAntero Salminen, Anu Kauppinen, Kai Kaarniranta · 2016 · Cellular Signalling
- Strategies for late phase preclinical and early clinical trials of senolyticsErin O. Wissler Gerdes, Avanish Misra, Jair Machado Espíndola‐Netto, Tamar Tchkonia, James L. Kirkland · 2021 · Mechanisms of Ageing and Development
- Unveiling the interplay of AMPK/SIRT1/PGC-1α axis in brain health: Promising targets against aging and NDDsPratik Shankar Rakshe, Bhaskar Jyoti Dutta, Shivani Chib, Niyogita Maurya, Sanjiv Singh · 2024 · Ageing Research Reviews
- Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevityAntero Salminen, Kai Kaarniranta, Anu Kauppinen · 2017 · Cellular Signalling
- Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee PollenAmira Mohammed Ali, Hiroshi Kunugi · 2020 · Foods
- Accelerated Kidney Aging in Diabetes MellitusJing Guo, Huijuan Zheng, Wenting Zhang, Wenjiao Lou, Chen Xia, Xue Ting Han, Wei Jun Huang, Fan Zhang, Yaoxian Wang, Wei Jing Liu · 2020 · Oxidative Medicine and Cellular Longevity
- The dialogue between the ubiquitin-proteasome system and autophagy: Implications in ageingJia Liang Sun‐Wang, Saška Ivanova, Antonio Zorzano A · 2020 · Ageing Research Reviews
- Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trialSaula Vigili de Kreutzenberg, Giulio Ceolotto, Anna Maria Cattelan, Elisa Pagnin, M. Mazzucato, Paolo Garagnani, Vincenzo Borelli, Maria Giulia Bacalini, Claudio Franceschi, Gian Paolo Fadini et al. · 2015 · Nutrition Metabolism and Cardiovascular Diseases
- Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cowsMiyako SUGIYAMA, Ryouka Kawahara‐Miki, Hirosuke KAWANA, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata · 2015 · Journal of Reproduction and Development
- Autophagy and Immune SenescenceHanlin Zhang, Daniel J. Puleston, Anna Katharina Simon · 2016 · Trends in Molecular Medicine
- Sex differences in the aging human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defenseMaria Luisa Barcena, Sofya Pozdniakova, Anja Andrea Kühl, István Baczkó, Yury V. Ladilov, Vera Regitz‐Zagrosek · 2019 · Aging
- Mitochondria: Potential Targets for OsteoarthritisXingjia Mao, Panfeng Fu, Linlin Wang, Chuan Xiang · 2020 · Frontiers in Medicine
- Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunctionLaura Pelletier, Matthieu Mantecon, Jennifer Gorwood, Martine Auclair, Roberta Foresti, Roberto Motterlini, Mireille Laforge, Michaël Atlan, Bruno Fève, Jacqueline Capeau et al. · 2021 · eLife
- SIRT3: As Simple As It Seems?David B. Lombard, Bernadette M. M. Zwaans · 2013 · Gerontology
- The role of hydrogen sulfide in aging and age-related pathologiesBernard W. Perridon, Henri G. D. Leuvenink, Jan‐Luuk Hillebrands, Harry van Goor, Eelke Marijn Bos · 2016 · Aging
- Mechanisms linking mitochondrial mechanotransduction and chondrocyte biology in the pathogenesis of osteoarthritisWeizhou Jiang, Huan Liu, Rongxue Wan, Yanjiao Wu, Zhanjun Shi, Wenhua Huang · 2021 · Ageing Research Reviews
- Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic RatsEmanuel Candeias, Inês Sebastião, Susana Cardoso, Cristina Carvalho, Maria Sancha Santos, Catarina Resende Oliveira, Paula Isabel Moreira, Ana Isabel Duarte · 2017 · Molecular Neurobiology
- Sirtuins: from metabolic regulation to brain agingWenzhen Duan · 2013 · Frontiers in Aging Neuroscience
- Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced PhenotypesJennifer G. Abelin, Jinal Patel, Xiaodong Lu, Caitlin M. Feeney, Lọla Fagbami, Amanda L. Creech, Roger Hu, Daniel Lam, Desiree Davison, Lindsay K. Pino et al. · 2016 · Molecular & Cellular Proteomics
- Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritisRonald K. June, Ru Liu‐Bryan, Fanxing Long, Timothy M. Griffin · 2016 · Journal of Orthopaedic Research®
- Hormesis determines lifespanEdward J. Calabrese, Marc A. Nascarella, Peter Pressman, Andrew Wallace Hayes, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese, Evgenios Agathokleous · 2024 · Ageing Research Reviews
- AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanismsAntero Salminen, Kai Kaarniranta, Anu Kauppinen · 2016 · Biogerontology
- Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?Hannah J. Smith, Arpit Sharma, William B. Mair · 2020 · Developmental Cell
- Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut MicrobiotaLaura Micheli, Laura Bertini, Agnese Bonato, Noemi Villanova, Carla Caruso, Maurizia Caruso, Roberta Bernini, Felice Tirone · 2023 · Nutrients
- Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cellsWenzheng Xia, Fengyun Zhang, Congying Xie, Miaomiao Jiang, Meng Hou · 2015 · Stem Cell Research & Therapy
- AMP-activated protein kinase reduces inflammatory responses and cellular senescence in pulmonary emphysemaXiao-Yu Cheng, Yangyang Li, Cheng Huang, Jun Li, Hongwei Yao · 2017 · Oncotarget
- Aging and cardiovascular diseases: the role of gene-diet interactionsCorella, Dolores, Ordovás, José M. · 2014 · Ageing Research Reviews
- Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanismsMaría Herranz‐López, Enrique Barrajón‐Catalán, Antonio Segura‐Carretero, Javier Abel Menéndez, Jorge Joven, Vicente Micol · 2015 · Phytomedicine
- Extending healthy ageing: nutrient sensitive pathway and centenarian populationSergio Davinelli, D. Craig Willcox, Giovanni Scapagnini · 2012 · Immunity & Ageing
- Phytochemicals-induced hormesis protects Caenorhabditis elegans against α-synuclein protein aggregation and stress through modulating HSF-1 and SKN-1/Nrf2 signaling pathwaysGovindan Shanmugam, Amirthalingam Mohankumar, Kalaiselvi Duraisamy, Govindhan Thiruppathi, Sundararaj Nivitha, Palanisamy Sundararaj · 2018 · Biomedicine & Pharmacotherapy
- Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathwaysYeon Jeong Jang, Hyun Jung Koo, Eun‐Hwa Sohn, Se Chan Kang, Dong‐Kwon Rhee, Suhkneung Pyo · 2015 · Food & Function
- Royal Jelly as an Intelligent Anti-Aging Agent—A Focus on Cognitive Aging and Alzheimer’s Disease: A ReviewAmira Mohammed Ali, Hiroshi Kunugi · 2020 · Antioxidants
- Antioxidant-Rich Functional Foods and Exercise: Unlocking Metabolic Health Through Nrf2 and Related PathwaysTkaczenko, Halina, Kurhaluk, Natalia · 2025 · International Journal of Molecular Sciences
- A breakdown in microglial metabolic reprogramming causes internalization dysfunction of α-synuclein in a mouse model of Parkinson’s diseaseLu, Jia, Wang, Chenfei, Cheng, Xin, Wang, Ruizhi, Yan, Xuehan, He, Pengju, Chen, Hongzhuan, Yu, Zhihua · 2022 · Journal of Neuroinflammation
- The Role of Autophagy for the Regeneration of the Aging LiverFengming Xu, Chuanfeng Hua, Hans‐Michael Tautenhahn, Olaf Dirsch, Uta Dahmen · 2020 · International Journal of Molecular Sciences
- AMPK: The energy sensor at the crossroads of aging and cancerVasudevarao Penugurti, Rajesh Manne, Ling Bai, Rajni Kant, Hui‐Kuan Lin · 2024 · Seminars in Cancer Biology
- Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathwayPeng Wang, Xiao Peng, Zuo‐Fu Wei, Fu-Yao Wei, Wei Wang, Wei-Dong Ma, Liping Yao, Yujie Fu, Yuangang Zu · 2015 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging TargetsLei Wu, Xinqiang Xie, Tingting Liang, Jun Ma, Lingshuang Yang, Juan Yang, Longyan Li, Yu Xi, Haixin Li, Jumei Zhang et al. · 2021 · Biomolecules
- The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependentMing-Min Chung, Yen‐Lin Chen, Dee Pei, Yi‐Chuan Cheng, Binggui Sun, Christopher J.B. Nicol, Chiahui Yen, Han‐Min Chen, Yao‐Jen Liang, Ming‐Chang Chiang · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Fibronectin type III domain‐containing 5 improves aging‐related cardiac dysfunction in miceCan Hu, Xin Zhang, Min Hu, Teng Teng, Yu‐Pei Yuan, Peng Kun Song, Chun‐Yan Kong, Si‐Chi Xu, Zhen‐Guo Ma, Qizhu Tang · 2022 · Aging Cell
- AMPK Signaling in Energy Control, Cartilage Biology, and OsteoarthritisDan Yi, Huan Yu, Ke Lu, Changshun Ruan, Changhai Ding, Liping Tong, Xiaoli Zhao, Di Chen · 2021 · Frontiers in Cell and Developmental Biology
- Metformin treatment ameliorates diabetes‐associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1Daisuke Tanokashira, Eiko Kurata, Wataru Fukuokaya, Kenshiro Kawabe, Kashiwada Mana, Hideyuki Takeuchi, Masamitsu Nakazato, Akiko Taguchi · 2018 · FEBS Open Bio
- Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevityNavakkode, Sheeja, Kennedy, Brian K. · 2024 · Frontiers in Aging Neuroscience
- Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cellsChih‐Li Lin, Wen‐Nung Huang, Hsin‐Hua Li, Chien‐Ning Huang, Sam Hsieh, Copper Lai, Fung‐Jou Lu · 2015 · Chemico-Biological Interactions
- Anti-inflammatory Mechanism of Ginseng Saponin Metabolite Rh3 in Lipopolysaccharide-Stimulated Microglia: Critical Role of 5′-Adenosine Monophosphate-Activated Protein Kinase Signaling PathwayYu‐Young Lee, Jin‐Sun Park, Eun-Jung Lee, SangYun Lee, Dong‐Hyun Kim, Jihee Lee Kang, Hee-Sun Kim · 2015 · Journal of Agricultural and Food Chemistry
- AMP-activated protein kinase: An attractive therapeutic target for ischemia-reperfusion injuryRong Ding, Wei Wu, Zhou Sun, Zhi Li · 2020 · European Journal of Pharmacology
- Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathwayYangmin Xia, Hao Zhang, Xiangyi Wu, Ye Xu, Qian Tan · 2024 · Biogerontology
- DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in Caenorhabditis elegansJennifer M. A. Tullet, Caroline Araiz, Matthew J. Sanders, Catherine Au, Alexandre Benedetto, Irene Papatheodorou, Emily H. Clark, Kathrin Schmeißer, Daniel Jones, Eugene F. Schuster et al. · 2014 · PLoS Genetics
- The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescenceTao Wang, Yan Yuan, Hui Zou, Jin‐Long Yang, Shiwen Zhao, Yonggang Ma, Yi Wang, Jianchun Bian, Xuezhong Liu, Jianhong Gu et al. · 2016 · Scientific Reports
- Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and diseaseRoshan Rajani, Núria M. Pastor‐Soler, Kenneth R. Hallows · 2017 · Current Opinion in Nephrology & Hypertension
- Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegansNkwachukwu Oziamara Okoro, Arome Solomon Odiba, Patience Ogoamaka Osadebe, Edwin Ogechukwu Omeje, Guiyan Liao, Wenxia Fang, Cheng Jin, Bin Wang · 2021 · Molecules
- Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyteAndrea Armani, Alessandra Berry, Francesca Cirulli, Massimiliano Caprio · 2017 · The FASEB Journal
- Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female miceStojakovic, Andrea, Trushin, Sergey, Sheu, Anthony, Khalili, Layla, Chang, Su-Youne, Li, Xing, Christensen, Trace, Salisbury, Jeffrey L., Geroux, Rachel E., Gateno, Benjamin et al. · 2021 · Communications Biology
- Extracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic NephropathyYu Ah Hong, Ji Hee Lim, Min Young Kim, Yaeni Kim, Hoon Suk Park, Hyung Wook Kim, Bum Soon Choi, Yoon Sik Chang, Hye Won Kim, Tae‐Yoon Kim et al. · 2017 · Antioxidants and Redox Signaling
- Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 1: Enhancement of cellular viability, regulation of cellular apoptosis and improvement of mitochondrial functionalitySadia Afrin, Massimiliano Gasparrini, Tamara Yuliett Forbes-Hernández, Danila Cianciosi, Patricia Reboredo‐Rodríguez, Piera Pia Manna, Maurizio Antonio Battino, Francesca Giampieri · 2018 · Food and Chemical Toxicology
- Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 SignalingYunyi Zou, Zhanglin Chen, Chen‐Chen Sun, Dong Kwon Yang, Zuoqiong Zhou, Xiyang Peng, Lan Zheng, Chenhao Tang · 2021 · International Journal of Molecular Sciences
- Splicing alterations in healthy aging and diseaseBrittany Lynn Angarola, Olga Anczuków · 2021 · Wiley Interdisciplinary Reviews - RNA
- Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagyJi Hee Lim, Hyung Wook Kim, Min Young Kim, Tae Woo Kim, Eun Nim Kim, Yaeni Kim, Sungjin Chung, Young Soo Kim, Bum Soon Choi, Yong‐Soo Kim et al. · 2018 · Cell Death and Disease
- The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up‐regulationLiu, Dong, Zhang, Yongqing, Gharavi, Robert, Park, Hee Ra, Lee, Jaewon, Siddiqui, Sana, Telljohann, Richard, Nassar, Matthew R., Cutler, Roy G., Becker, Kevin G. et al. · 2015 · Journal of Neurochemistry
- Mechanisms Involved in Gut Microbiota Regulation of Skeletal MuscleGuangyao Li, Binghui Jin, Zhe Fan · 2022 · Oxidative Medicine and Cellular Longevity
- Roles of tau pathology in the locus coeruleus (LC) in age-associated pathophysiology and Alzheimer’s disease pathogenesis: Potential strategies to protect the LC against agingAkiko Satoh, Koichi Iijima · 2017 · Brain Research
- Metformin activation of AMPK suppresses AGE-induced inflammatory response in hNSCsChung, Ming-Min, Nicol, Christopher J., Cheng, Yi-Chuan, Lin, Kuan-Hung, Chen, Yen-Lin, Pei, Dee, Lin, Chien-Hung, Shih, Yi-Nuo, Yen, Chia-Hui, Chen, Shiang-Jiuun et al. · 2017 · Experimental Cell Research
- Novel strategies for anti-aging drug discoverySaraswat, Komal, Rizvi, Syed Ibrahim · 2017 · Expert Opinion on Drug Discovery
- Targeting AMPK signaling by polyphenols: a novel strategy for tackling agingWei Xu, Yi Luo, Jiaxin Yin, Mengzhen Huang, Feijun Luo · 2022 · Food & Function
- Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathwayBokyung Sung, JI WON CHUNG, Ha Ram Bae, Jae Sue Choi, Cheol Min Kim, Nam Deuk Kim · 2015 · Experimental and Therapeutic Medicine
- Yeast replicative aging: a paradigm for defining conserved longevity interventionsBrian M. Wasko, Matt R. Kaeberlein · 2013 · FEMS Yeast Research
- Sirtuins in mitochondrial stress: Indispensable helpers behind the scenesShuang‐Zhe Lin, Haiping Xing, Tongtong Zang, Xin Ruan, Lulu Wo, Ming He · 2018 · Ageing Research Reviews
- Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and suppression of mTOR in athymic nude miceMatthew J. Nemec, Hyemee Kim, Alexandria B. Marciante, Ryan C. Barnes, Erik D. Hendrick, William H. Bisson, Stephen T. Talcott, Susanne U. Mertens‐Talcott · 2016 · The Journal of Nutritional Biochemistry
- The role of AMPK in metabolism and its influence on DNA damage repairMichał Szewczuk, Karolina Boguszewska, Julia Kaźmierczak-Barańska, Bolesław T. Karwowski · 2020 · Molecular Biology Reports
- Antioxidative Stress Mechanisms behind Resveratrol: A Multidimensional AnalysisTongyu Gu, Nianmin Wang, Tong Wu, Qi Ge, Liang Chen · 2021 · Journal of Food Quality
- Ras signaling in aging and metabolic regulationCathy Slack · 2017 · Nutrition and Healthy Aging
- Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1αHoe‐Yune Jung, Dong-Yeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go, Namgyu Lee, Dohyun Lee, Heehwa G. Son, Jongsu Jeon, Seong‐Hoon Kim et al. · 2017 · Scientific Reports
- Advantages and disadvantages of apoptosis in the aging processSandro Argüelles, Angélica Guerrero‐Castilla, Mercedes Cano, Mario Muñoz, Antonio Ayala · 2019 · Annals of the New York Academy of Sciences
- SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular LifespanPriya Mishra, Amit Kumar Mittal, Harikesh Kalonia, Swati Madan, Shampa Ghosh, Jitendra Kumar Sinha, Satyendra Kumar Rajput · 2020 · Current Neuropharmacology
- Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibitionElena M. V. de Cavanagh, Felipe Inserra, León Ferder · 2015 · American Journal of Physiology-Heart and Circulatory Physiology
- Fucoxanthin prevents lipopolysaccharide-induced depressive-like behavior in mice via AMPK- NF-κB pathwayXi Jiang, Guokang Wang, Qian Lin, Zhihua Tang, Qizhi Yan, Xuefeng Yu · 2018 · Metabolic Brain Disease
- Ex Vivo Molecular Rejuvenation Improves the Therapeutic Activity of Senescent Human Cardiac Stem Cells in a Mouse Model of Myocardial InfarctionElisa Avolio, Giuseppe Gianfranceschi, Daniela Cesselli, Angela Caragnano, Emmanouil Athanasakis, Rajesh Katare, Marco Meloni, Anita Palma, Arianna Barchiesi, Carlo Vascotto et al. · 2014 · Stem Cells
- AMPK activation can delay agingAndreea Lucia Stancu · 2015 · Discoveries
- Strawberry extracts efficiently counteract inflammatory stress induced by the endotoxin lipopolysaccharide in Human Dermal FibroblastMassimiliano Gasparrini, Francesca Giampieri, Tamara Yuliett Forbes-Hernández, Sadia Afrin, Danila Cianciosi, Patricia Reboredo‐Rodríguez, Alfonso Varela‐López, Jiaojiao Zhang, José Luis Quiles, Bruno Mezzetti et al. · 2018 · Food and Chemical Toxicology
- The role of the immunosuppressive PD-1/PD-L1 checkpoint pathway in the aging process and age-related diseasesAntero Salminen · 2024 · Journal of Molecular Medicine
- Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegansEsmaeil Dehghan, Mohammad Goodarzi, Bahar Saremi, Rueyling Lin, Hamid Mirzaei · 2019 · Nature Communications
- Curcumin elevates sirtuin level but does not postponein vitrosenescence of human cells building the vasculatureWioleta Grabowska, Małgorzata Suszek, Maciej Wnuk, Anna Lewińska, Emilia Wasiak, Ewa Sikora, Anna Bielak-Żmijewska · 2016 · Oncotarget
- Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK BiobankShan Luo, Ian Chi Kei Wong, Celine Sze Ling Chui, Jie Zheng, Yuan Huang, Catherine Mary Schooling, Shiu Lun Au Yeung · 2023 · The Lancet Healthy Longevity
- AAK-2 and SKN-1 Are Involved in Chicoric-Acid-Induced Lifespan Extension in Caenorhabditis elegansYe Peng, Quancai Sun, Ruichang Gao, Yeonhwa Park · 2019 · Journal of Agricultural and Food Chemistry
- Inhibition of 3-phosphoinositide–dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblastsSugyun An, Si‐Young Cho, Junsoo Kang, Soobeom Lee, Hyung-Su Kim, Daejin Min, Eui-Dong Son, Kwang‐Hyun Cho · 2020 · Proceedings of the National Academy of Sciences
- Management of anemia of inflammation in the elderlyMacciò, Antonio, Madeddu, Clelia · 2012 · Anemia
- AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the BrainSantosh Ramamurthy, Gabriele V. Ronnett · 2012 · Experimental Neurobiology
- Alpha-synuclein, epigenetics, mitochondria, metabolism, calcium traffic, & circadian dysfunction in Parkinson’s disease. An integrated strategy for managementOliver T. Phillipson · 2017 · Ageing Research Reviews
- Ameliorative Effect of Dietary Tryptophan on Neurodegeneration and Inflammation in d -Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway and Gut MicrobiotaJia Yin, Bowei Zhang, Zhenting Yu, Yaozhong Hu, Huan Lv, Xuemeng Ji, Jin Wang, Bo Peng, Shuo Wang · 2021 · Journal of Agricultural and Food Chemistry
- Gut Microbiota‐Derived Indole Derivatives Alleviate Neurodegeneration in Aging through Activating GPR30/AMPK/SIRT1 PathwayJia Yin, Yunhui Zhang, Xiaoxia Liu, Wanhua Li, Yaozhong Hu, Bowei Zhang, Shuo Wang · 2023 · Molecular Nutrition & Food Research
- Tubulin Post-Translational Modifications: The Elusive Roles of AcetylationBruno Carmona, H. Susana Marinho, Catarina Lopes Matos, Sofia Nolasco, Helena Soares · 2023 · Biology
- Mechanisms Underlying Brain Aging Under Normal and Pathological ConditionsMenglong Jin, Shi‐Qing Cai · 2022 · Neuroscience Bulletin
- Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular DiseaseDaniel E. Forman, George A. Kuchel, John C. Newman, James L. Kirkland, Elena Volpi, George E. Taffet, Nir Barzilai, Ambarish Pandey, Dalane W. Kitzman, Peter Libby et al. · 2023 · Journal of the American College of Cardiology
- AMPK Plays a Dual Role in Regulation of CREB/BDNF Pathway in Mouse Primary Hippocampal CellsWeidong Huang, Jie Cao, Xiaobin Liu, Facai Meng, Min Li, Bo Chen, Jie Zhang · 2015 · Journal of Molecular Neuroscience