Potential roles of gut microbiota and microbial metabolites in Parkinson’s disease

A human gut microbial gene catalogue established by metagenomic sequencing

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Diversity of the Human Intestinal Microbial Flora

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Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

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Overlapping Mechanisms of Action of Brain-Active Bacteria and Bacterial Metabolites in the Pathogenesis of Common Brain Diseases

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An updated overview on the relationship between human gut microbiome dysbiosis and psychiatric and psychological disorders

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Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

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Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease

Guo, T.-T., Zhang, Z., Sun, Y., Zhu, R.-Y., Wang, F.-X., Ma, L.-J., Jiang, L., & Liu, H.-D. (2023) · Nutrients · doi:10.3390/nu15040930 · Cited by 82

Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic

Duan, W.-X., Wang, F., Liu, J., & Liu, C. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01123-9 · Cited by 91

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases

Yuan, C., He, Y., Xie, K., Feng, L., Gao, S., & Cai, L. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1282431 · Cited by 87

Inflammatory microbes and genes as potential biomarkers of Parkinson’s disease

Nie, S., Wang, J., Deng, Y., Ye, Z., & Ge, Y. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00367-z · Cited by 69

Respiratory tract infections and gut microbiome modifications: A systematic review

Woodall, C. A., McGeoch, L. J., Hay, A. D., & Hammond, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262057 · Cited by 66

Gut-Brain Axis a Key Player to Control Gut Dysbiosis in Neurological Diseases

Pan, I., Issac, P. K., Rahman, M. M., Guru, A., & Arockiaraj, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03691-3 · Cited by 62

Metagenomics of the Gut Microbiome in Parkinson's Disease: Prodromal Changes

Palacios, N., Wilkinson, J., Bjornevik, K., Schwarzschild, M. A., McIver, L., Ascherio, A., & Huttenhower, C. (2023) · Annals of Neurology · doi:10.1002/ana.26719 · Cited by 59

Neuroprotective effects of an engineered Escherichia coli Nissle 1917 on Parkinson's disease in mice by delivering GLP ‐1 and modulating gut microbiota

Wu, H., Wei, J., Zhao, X., Liu, Y., Chen, Z., Wei, K., Lu, J., Chen, W., Jiang, M., Li, S., et al. (2022) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10351 · Cited by 59

Gastrodia elata polysaccharide alleviates Parkinson's disease via inhibiting apoptotic and inflammatory signaling pathways and modulating the gut microbiota

Gan, Q., Peng, M., Wei, H., Chen, L., Chen, X.-Y., Li, Z.-H., An, G., & Ma, Y. (2024) · Food & Function · doi:10.1039/d3fo05169b · Cited by 58

The roles of gut microbiota and its metabolites in diabetic nephropathy

Zhao, H., Yang, C.-E., Liu, T., Zhang, M., Niu, Y., Wang, M., & Yu, J. Q. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1207132 · Cited by 55

Associations between gut microbiota and Parkinson disease: A bidirectional Mendelian randomization analysis

Li, J., Li, J., Tang, B., & Guo, J. (2023) · European Journal of Neurology · doi:10.1111/ene.15848 · Cited by 56

The pathogenesis and treatment mechanism of Parkinson's disease from the perspective of traditional Chinese medicine

Chen, P., Zhang, J., Wang, C., Chai, Y., Wu, A., Huang, N., & Wang, L. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154044 · Cited by 55

Gut Microbiome and Mycobiome Alterations in an In Vivo Model of Alzheimer’s Disease

D’Argenio, V., Veneruso, I., Gong, C., Cecarini, V., Bonfili, L., & Eleuteri, A. M. (2022) · Genes · doi:10.3390/genes13091564 · Cited by 46

Differences in the Composition of Gut Microbiota between Patients with Parkinson’s Disease and Healthy Controls: A Cohort Study

Zapała, B., Stefura, T., Wójcik-Pędziwiatr, M., Kabut, R., Bałajewicz-Nowak, M., Milewicz, T., Dudek, A., Stój, A., & Rudzińska-Bar, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235698 · Cited by 44

Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health

Cocean, A.-M., & Vodnar, D. C. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111073 · Cited by 52

Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice

Xu, R.-C., Miao, W.-T., Xu, J., Xu, W. V., Liu, M.-R., Ding, S., Jian, Y.-X., Lei, Y.-H., Yan, N., & Liu, H.-D. (2022) · Nutrients · doi:10.3390/nu14194163 · Cited by 41

Comprehensive Review on Potential Signaling Pathways Involving the Transfer of α-Synuclein from the Gut to the Brain That Leads to Parkinson’s Disease

Kumari, S., Taliyan, R., & Dubey, S. K. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00730 · Cited by 40

A Narrative Review on the Advance of Probiotics to Metabiotics

Jang, H. J., Lee, N., & Paik, H. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2311.11023 · Cited by 40

The role of the microbiota-gut-brain axis and intestinal microbiome dysregulation in Parkinson’s disease

Li, Q., Meng, L., Chen, L., Shi, X., Tu, L., Zhou, Q. G., Yu, J.-L., Liao, X., Zeng, Y., & Yuan, Q. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1185375 · Cited by 38

Emerging insights between gut microbiome dysbiosis and Parkinson’s disease: Pathogenic and clinical relevance

Bi, M., Feng, L., He, J., Liu, C., Wang, Y., Jiang, H., & Liu, S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101759 · Cited by 32

The link between increased Desulfovibrio and disease severity in Parkinson’s disease

Nie, S., Jing, Z., Wang, J., Deng, Y., Zhang, Y., Ye, Z., & Ge, Y. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12489-1 · Cited by 32

Gut dysfunction may be the source of pathological aggregation of alpha-synuclein in the central nervous system through Paraquat exposure in mice

Wang, K., Zhang, C., Zhang, B., Li, G., Shi, G., Cai, Q., & Huang, M. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114152 · Cited by 33

Role of the microbiota in inflammation-related related psychiatric disorders

Zhou, L., Wu, Q. J., Jiang, L., Rao, J., Gao, J., Zhao, F., & Wang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1613027 · Cited by 31

The relationship between Parkinson’s disease and gastrointestinal diseases

Zeng, J., Wang, X., Pan, F., & Mao, Z. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.955919 · Cited by 26

Interplay of human gastrointestinal microbiota metabolites: Short-chain fatty acids and their correlation with Parkinson’s disease

Liu, J., Chen, Q., & Su, R. (2024) · Medicine · doi:10.1097/md.0000000000037960 · Cited by 25

The Pathology and Physiology of Ileostomy

Ma, H., Li, X., Yang, H., Qiu, Y., & Xiao, W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.842198 · Cited by 29

Aging, testosterone, and neuroplasticity: friend or foe?

Saleki, K., Banazadeh, M., Saghazadeh, A., & Rezaei, N. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0033 · Cited by 27

Sleep deprivation accelerates Parkinson's disease via modulating gut microbiota associated microglial activation and oxidative stress

Zhu, W., Hu, Y., Shi, Y., Bao, H., Cheng, X., Jiang, M., Peng, Z., Song, J., Fang, F., Jian, C., et al. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128077 · Cited by 25

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway

Ma, X., Li, M., Zhang, Y., Xu, T., Zhou, X., Qian, M., Yang, Z., & Han, X. (2023) · eLife · doi:10.7554/elife.92906.5 · Cited by 43

The link between the gut microbiome, inflammation, and Parkinson’s disease

Nie, S., & Ge, Y. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12789-6 · Cited by 23

Multidirectional associations between the gut microbiota and Parkinson’s disease, updated information from the perspectives of humoral pathway, cellular immune pathway and neuronal pathway

Jia, X., Chen, Q., Zhang, Y., & Asakawa, T. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1296713 · Cited by 22

Gut Microbiota-Based Interventions for Parkinson’s Disease: Neuroprotective Mechanisms and Current Perspective

Kumar, D., Bishnoi, M., Kondepudi, K. K., & Sharma, S. S. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10433-x · Cited by 22

Gut microbiota-associated taurine metabolism dysregulation in a mouse model of Parkinson’s disease

Cui, C., Song, H., Han, Y., Yu, H., Li, H., Yang, Y., & Zhang, B. (2023) · mSphere · doi:10.1128/msphere.00431-23 · Cited by 21

Gut microbiota and tuberculosis infection: interaction and therapeutic potential

Chai, Y., Li, M., Deng, X., Ma, C., Zhou, N., Chen, Y., Yao, Y., Li, K. C., Gong, W., & Lei, H. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2531201 · Cited by 25

Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota–Brain–Skin Axis

Tang, L., Cao, X., Chen, S., Jiang, X., Li, D., & Chen, G. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00205 · Cited by 20

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Fehér, J., Élő, Á., István, L., Nagy, Z. Z., Radak, Z. O., Scuderi, G., Artico, M., & Kovács, I. (2022) · GeroScience · doi:10.1007/s11357-022-00620-5 · Cited by 20

The alteration of intestinal mucosal α-synuclein expression and mucosal microbiota in Parkinson’s disease

Shi, J., Wang, Y., Chen, D., Xu, X., Li, W., Li, K., He, J., Su, W., & Luo, Q. (2023) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-023-12410-w · Cited by 19

Memory in Misfire: The Gut Microbiome-Trained Immunity Circuit in Inflammatory Bowel Diseases

Yang, B., Wu, J., Hou, X., Bai, T., & Liu, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199663 · Cited by 19

Metabolic modeling links gut microbiota to metabolic markers of Parkinson’s disease

Hensen, T., & Thiele, I. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2554195 · Cited by 16

Effect of the gut microbiome in glaucoma risk from the causal perspective

Wu, Y., Shi, R., Chen, H., Zhang, Z., Bao, S., Qu, J., & Zhou, M. (2024) · BMJ Open Ophthalmology · doi:10.1136/bmjophth-2023-001547 · Cited by 16

Higher dietary butyrate intake is associated with better cognitive function in older adults: evidence from a cross-sectional study

Tu, J., Zhang, J., & Chen, G. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1522498 · Cited by 16

Infectious Agents as Potential Drivers of α‐Synucleinopathies

Linard, M., Ravier, A., Mougué, L., Grgurina, I., Boutillier, A., Foubert‐Samier, A., Blanc, F., & Helmer, C. (2022) · Movement Disorders · doi:10.1002/mds.28925 · Cited by 19

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathwayPreprint

Ma, X., Li, M., Zhang, Y., Xu, T., Zhou, X., Qian, M., Yang, Z., & Han, X. (2023) · eLife · doi:10.7554/elife.92906 · Cited by 16

Microbiome Alterations and Alzheimer’s Disease: Modeling Strategies with Transgenic Mice

López-Villodres, J. A., Escamilla, A., Mercado-Sáenz, S., Alba-Tercedor, C., Rodríguez‐Pérez, L., Arranz‐Salas, I., Sanchez-Varo, R. M., & Bermúdez, D. (2023) · Biomedicines · doi:10.3390/biomedicines11071846 · Cited by 16

Multi-omics analysis of gut-brain axis reveals novel microbial and neurotransmitter signatures in patients with arteriosclerotic cerebral small vessel disease

Huang, J., Liu, S., Li, P., Wei, L., Lin, G., Lin, J., Luo, Y., Liu, Y., Mao, Y., Ruan, H., et al. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107385 · Cited by 16

Exploring the role of gut microbiota in Parkinson’s disease: insights from fecal microbiota transplantation

Guo, M., Gao, H., Wang, Y., & Xiang, Y. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1574512 · Cited by 18

The Interaction Between Nutraceuticals and Gut Microbiota: a Novel Therapeutic Approach to Prevent and Treatment Parkinson’s Disease

Yao, L., Yang, Y., Yang, X., & Rezaei, M. J. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04151-2 · Cited by 15

Neuronal control of microglia through the mitochondria

Pereira-Santos, A. R., Candeias, E., Magalhães, J. D., Empadinhas, N., Esteves, A. R., & Cardoso, S. M. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167167 · Cited by 13

Partially Hydrolyzed Guar Gum Intake Supports the Gut Microbiota and Attenuates Inflammation during Influenza H1N1 Virus Infection in Mice

Kato, T., Kamiya, S., Narasaki, S., Sumii, A., Tsutsumi, Y. M., Machida, K., Hara, K., Izumi-Mishima, Y., Tsutsumi, R., & Sakaue, H. (2023) · Nutrients · doi:10.3390/nu15194252 · Cited by 13

The gut microbiota influences neurodegenerative diseases through the gut-brain axis: molecular mechanisms and effects on immune function

Yang, J., Song, X., Yan, S., Li, Q., & Yang, W. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1739329 · Cited by 13

The Determination of Trimethylamine N-Oxide and Organic Acids Connected with Gut Microbiota in the Urine of Parkinson’s Disease Patients: A Pilot Study

Gątarek, P., Pawelczyk, M., Bobrowska‐Korczak, B., Giebułtowicz, J., Glabinski, A. R., & Kałużna‐Czaplińska, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104575 · Cited by 11

New Pieces for an Old Puzzle: Approaching Parkinson’s Disease from Translatable Animal Models, Gut Microbiota Modulation, and Lipidomics

Moreno, L. O., Bagüés, A., Martínez, V., & Abalo, R. (2023) · Nutrients · doi:10.3390/nu15122775 · Cited by 11

The Intricate Interplay: Microbial Metabolites and the Gut‐Liver‐Brain Axis in Parkinson's Disease

Kishanchand, D. K., A., A. K. K., Chandrababu, K., Philips, C. A., Sivan, U., & Chakrapani, P. S. B. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70016 · Cited by 13

The role of the gut microbiota in neuropsychiatric disorders and therapy

Zhang, F., Ding, K., Zhang, L., Liu, D., Dong, X., Wang, M., Zhou, F.-L., Sun, Y., Zhang, W., Yu, Y., et al. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102894 · Cited by 11

Development of a H2S-responsive NIR Fluorescent Probe for H2S Detection and H2S Releasing Monitoring From Prodrug

Wu, M., Wang, S., Hai, W., Lu, X., & Li, P. (2023) · Journal of Fluorescence · doi:10.1007/s10895-023-03187-2 · Cited by 9

Plasma Metabolites as Mediators Between Gut Microbiota and Parkinson’s Disease: Insights from Mendelian Randomization

Chen, J., Zhu, L., Wang, F., Zhu, Y., Chen, J., Liang, C., Liu, B., Pang, A., & Yang, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04765-0 · Cited by 9

Alterations of Gut Microbiota and Microbial Metabolites in Parkinson’s Disease: A Systematic Review

Davoody, S., Vakili, K. G., Jazi, K., Fathi, M., Heidari‐Foroozan, M., Mofidi, S. A., Taremi, M., Taherkhani, A., Azadnajafabad, S., Hojjatipour, F., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05598-7 · Cited by 7

Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder

Vashishth, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102466 · Cited by 8

Concomitant gut dysbiosis and defective gut barrier serve as the bridges between hypercortisolism and chronic systemic inflammation in Cushing’s disease

Lin, B. C., Melnikov, V., Guo, S., Cao, Z., Ye, Z., Ye, Z., Ji, C., Chen, J., Wang, J., Zhang, H., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae139 · Cited by 7

Age-driven dysbiosis: gut microbiota in the pathogenesis and treatment of aging disorders

Kopalli, S. R., Wankhede, N. L., Rahangdale, S. R., Sammeta, S. S., Aglawe, M. M., Koppula, S., Taksande, B. G., Upaganlawar, A., Umekar, M. J., & Kale, M. B. (2026) · Biogerontology · doi:10.1007/s10522-026-10389-1 · Cited by 6

Hydrogen Sulfide (H2S) Generated in the Colon Induces Neuropathic Pain by Activating Spinal NMDA Receptors in a Rodent Model of Chronic Constriction Injury

Wang, J., Zhang, N., Liu, H.-Z., Wang, J.-L., Zhang, Y., Su, D.-D., Zhang, L.-M., Li, B., Miao, H., & Miao, J. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04342-w · Cited by 6

Frontiers and future perspectives of neuroimmunology

Qi, H., Duan, S., Xu, Y., & Zhang, H. (2022) · Fundamental Research · doi:10.1016/j.fmre.2022.10.002 · Cited by 5

Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic‐Comorbidities Related Signatures in Craniopharyngioma

Lin, B. C., Ye, Z., Cao, Z., Ye, Z., Yu, Y., Jiang, W., Guo, S., Melnikov, V., Zhou, P., Ji, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202400684 · Cited by 5

Retrospective analysis of diet and gut microbiota diversity and clinical pharmacology outcomes in patients with Parkinsonism syndrome

Hu, Y., Wang, H., Zhong, Y., & Sun, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38645 · Cited by 5

Neuroimmune modulators derived from natural products: Mechanisms and potential therapies

Feng, W.-D., Liu, D.-N., Shang, Y.-F., Zhang, W., Xu, S., Feng, D.-H., & Wang, Y. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108830 · Cited by 5

Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease

Li, W., Yang, J.-H., Liu, L., Ding, S., Yu, B., Jiang, L., Yan, N., & Liu, H.-D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1580029 · Cited by 6

Ingestible electronic capsules for in situ sensing of diverse biomarkers

Zhang, C., Song, H., Zeng, J., Chen, J., Ni, C., Chung, H. U., Xu, K., Ying, B., & Nan, K. (2025) · Device · doi:10.1016/j.device.2025.100935 · Cited by 4

Unraveling the Relation of Parkinson's Disease and Metabolites: A Combined Analysis of Stool and Plasma Metabolites Based on Untargeted Metabolomics Technology

Liu, S., Zhao, Q., Tang, J., Li, X., Wang, J., Zhao, Y., Yang, Z., Pan, X., Xiang, R. H., Tian, J., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70424 · Cited by 4

Exploring the relationship between novel Coronavirus pneumonia and Parkinson’s disease

Xi, X., & Han, L. (2022) · Medicine · doi:10.1097/md.0000000000031813 · Cited by 4

Akkermansia muciniphila identified as key strain to function in pathogen invasion and intestinal stem cell proliferation through Wnt signaling pathwayPreprint

Ma, X., Li, M., Xu, T., Zhou, X., Qian, M., Yang, Z., Cao, K., & Han, X. (2023) · eLife · doi:10.7554/elife.92906.1 · Cited by 4

From dysbiosis to dysfunction: specific gut microbes and metabolites in the pathogenesis of Parkinson’s disease

Chi, F., Chen, K., Yin, Y., Hakovirta, J. R., & Saris, P. E. J. (2026) · Sustainable Microbiology · doi:10.1093/sumbio/qvag002 · Cited by 5

Gut microbiota changes are associated with abnormal metabolism activity in children and adolescents with obsessive-compulsive disorder

Dai, J., Li, M., He, J., Duan, L., Zhu, X., Liu, L., Meng, M., Shao, X., & Zhu, G. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.12.041 · Cited by 4

Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease

Yang, K., Zeng, R., Zheng, Y., Zhong, S., Wang, J., Yu, X., Zhong, H., Chen, X., Shi, Y., Lin, F., et al. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01098-6 · Cited by 3

Research progress on natural products in regulating the gut microbiota in Parkinson’s disease

Jia, Y., Zhang, Y., Tai, X., Zhao, T., Zhang, H., & Zhou, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1667694 · Cited by 4

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Ali, I., Martin, J., Zárate-Potes, A., & Benedetto, A. (2022) · Journal of Visualized Experiments · doi:10.3791/63860 · Cited by 4

Fecal microbiota transplantation for glaucoma; a potential emerging treatment strategy

Ebrahimi, R., Farsi, Y., & Nejadghaderi, S. A. (2024) · Current Research in Microbial Sciences · doi:10.1016/j.crmicr.2024.100314 · Cited by 4

Gut microbiome and diabetic kidney disease: Insights from Mendelian randomization and genetic correlations

Yang, K., Zhao, Z., Yin, Y., Liu, Y., & Wu, X. (2025) · Medicine · doi:10.1097/md.0000000000042492 · Cited by 2

Effects of gut microbiota on cognitive impairment in Parkinson’s disease: a comprehensive Mendelian randomization and case–control study

Feng, Y., Chang, Q., Zhou, H., Zhang, W., Xie, L., Deng, X., Chen, T., & Liu, W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1620449 · Cited by 2

WuMei-pill alleviates Parkinson's disease induced by dopamine neuron damage in mice by regulating the gut-brain-microbiome axis

Zhang, Z., Shen, L., Bai, Y., Li, S., & Wang, S. (2025) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2025.101632 · Cited by 2

Association Between Blood-Brain Barrier Disruption and Gut Microbiota Dysbiosis in Parkinson’s Disease

Yao, W., Liu, L., Wang, J., Chen, S., Zhang, C., Liao, R., Wang, Y., Ou, K., Jiang, L., Yu, Y., et al. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01738-2 · Cited by 1

New insights in non-motor symptoms in Parkinson’s disease

Falup‐Pecurariu, C., Fanciulli, A., Borgohain, R., Chaudhuri, К. R., & Metta, V. (2024) · Frontiers research topics · doi:10.3389/978-2-8325-4722-9 · Cited by 1

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathwayPreprint

Ma, X., Li, M., Zhang, Y., Xu, T., Zhou, X., Qian, M., Yang, Z., & Han, X. (2024) · eLife · doi:10.7554/elife.92906.2 · Cited by 1

Neuromicrobiology of Neurodegenerative Diseases:Preprint

Nandi, A., Nandi, A., Kaur, A., Ghai, S., Singh, G., & Tiwari, A. (2023) · doi:10.14293/pr2199.000546.v1

Research and treatment discussions regarding the potential impact of gut microbiota on Parkinson's disease

Tang, H. (2023) · International Journal of Frontiers in Medicine · doi:10.25236/ijfm.2023.051216

Effects of acupuncture on Parkinson's disease-related constipation and roles of gut microbial ecology: study protocol for a randomized controlled clinical trialPreprint

Lei, S., Fan, J., Quan, J., Li, Y., Cen, M., Xu, X., Liu, X., Wu, S., Liao, K., Lin, S., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4171150/v1

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathwayPreprint

Ma, X., Li, M., Zhang, Y., Xu, T., Zhou, X., Qian, M., Yang, Z., & Han, X. (2024) · eLife · doi:10.7554/elife.92906.3

Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathwayPreprint

Ma, X., Meng, L., Zhang, Y., Xu, T., Zhou, X., Qian, M., Yang, Z., & Han, X. (2024) · eLife · doi:10.7554/elife.92906.4

Research Progress on the Relationship between Gut Microbiome and Parkinson’s Disease

力比奴尔·塞地尔丁, 克. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14123217

Comorbidity of inflammatory bowel diseases and Parkinson’s disease

Трухан, Д. И., Konshu, N. V., & Олеговна, М. П. (2025) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2025-170

Effects and mechanisms of acupuncture for PIGD-subtype Parkinson’s disease via integration of fMRI and gut microbiota-metabolomics analysis: protocol for a prospective randomized controlled trial

Sheng, J., Xu, Y., Liu, T., Zhu, J., Mu, C., Zhai, L., Xu, S., Wang, H., Liu, X., Liu, T., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1534165

Intestinal flora in aging: a scientific perspective on food intervention

Ye, X., Guan, Y., Chen, P., Zhu, J., Liu, Y., Chen, J., Zhu, K., Jin, Z., Luo, S., Cai, J., et al. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250713

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

Pan, T., Yuan, L., Zhao, R., Lu, L., Zhi, Y., Li, Y., Wu, M., & Huang, Y. (2025) · MedComm – Oncology · doi:10.1002/mog2.70044

Exploring the therapeutic potential of the gut microbiota metabolite 3‑indolepropionic acid in parkinson’s disease: a network pharmacology, molecular docking and cell viability study

Zheng, Q. G., Han, S., He, L., & Chen, Y. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01794-z

Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson’s disease

Liu, R. X., Ma, Y., Li, Y., Gao, X., Wang, S., Xu, L., Liu, G., Chen, H., Ji, M., & Hou, H. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1823372

The Human Microbiome in Airborne Particulate Matter–Associated Aging-Related Chronic Diseases: An Evidence-Stratified Review

Yang, Y., Liu, X., Wang, M., Zhu, X., Yang, B., Cao, J., Song, Y., & Jiang, G. (2026) · Environment & Health · doi:10.1021/envhealth.5c00852

Bidirectional mendelian randomization links circulating inflammation and gut microbiota to synucleinopathies, validated by probiotic modulation in a Parkinson’s disease mouse model

Zheng, X., Li, L., Huang, Z., & Zhou, L. (2026) · Brain Network Disorders · doi:10.1016/j.bnd.2026.06.001

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease

Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445

Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota

Zhao, R., Mu, B., Wang, D., XinHuang, Ma, Q., & Lu, M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04584-9 · Cited by 24

From dysbiosis to dysfunction: specific gut microbes and metabolites in the pathogenesis of Parkinson’s disease

Chi, F., Chen, K., Yin, Y., Hakovirta, J. R., & Saris, P. E. J. (2026) · Sustainable Microbiology · doi:10.1093/sumbio/qvag002 · Cited by 5

The role of the gut microbiome in Parkinson’s disease

Metcalfe‐Roach, A., & Finlay, B. B. (2025) · Future Neurology · doi:10.1080/14796708.2025.2494981 · Cited by 6

Emerging insights between gut microbiome dysbiosis and Parkinson’s disease: Pathogenic and clinical relevance

Bi, M., Feng, L., He, J., Liu, C., Wang, Y., Jiang, H., & Liu, S. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101759 · Cited by 32