Cited by 445Gut microbiota and healthParkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease

Sun, Meng-Fei, Shen, Yan-Qin·2018·Ageing Research Reviews

Abstract

Gut microbial dysbiosis and alteration of microbial metabolites in Parkinson's disease (PD) have been increasingly reported. Dysbiosis in the composition and abundance of gut microbiota can affect both the enteric nervous system and the central nervous system (CNS), indicating the existence of a microbiota-gut-brain axis and thereby causing CNS diseases. Disturbance of the microbiota-gut-brain axis has been linked to specific microbial products that are related to gut inflammation and neuroinflammation. Future directions should therefore focus on the exploration of specific gut microbes or microbial metabolites that contribute to the development of PD. Microbiota-targeted interventions, such as antibiotics, probiotics and fecal microbiota transplantation, have been shown to favorably affect host health. In this review, recent findings regarding alterations and the role of gut microbiota and microbial metabolites in PD are summarized, and potential molecular mechanisms and microbiota-targeted interventions in PD are discussed.

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Crossref · 10.1016/j.arr.2018.04.004

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Authors
Sun, M.-F., & Shen, Y.-Q.
Affiliations
Jiangnan University (CN)
Corresponding author
Shen, Yan-Qin
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2018-08
Volume
45
Pages
53-61
ISSN
1568-1637 (ISSN-L)
OpenAlex
W2801763052
Cited by
445
References
128
Citations by year
2026: 40 · 2025: 67 · 2024: 72 · 2023: 67 · 2022: 78 · 2021: 59 · 2020: 28 · 2019: 26 · 2018: 8
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National natural science foundation of China (81771384, 81650007)
  • Jiangsu Natural Science Foundation of China (BK20151127)
  • Postgraduate Research & Practice Innovation Program of Jiangsu Province of China (KYZZ16_0310)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Parkinson's disease, gut dysbiosis, microbial metabolites, microbiota-gut-brain axis, neuroinflammation, intestinal inflammation, enteric nervous system, probiotics, fecal microbiota transplantation, antibiotics, microbiota-targeted interventions
MeSH terms
Gastrointestinal Microbiome, Animals, Brain, Humans, Inflammation, Parkinson Disease, Gastrointestinal Tract, Dysbiosis

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