The DOI matches its Crossref record; 201 of the 201 references it cites were found in a registry or an index.
Adipose–Muscle crosstalk in age-related metabolic disorders: The emerging roles of adipo-myokines
Abstract
Obesity and type 2 diabetes account for a considerable proportion of the global burden of age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and metabolic regulation have been primarily linked to endocrine processes. Skeletal muscle and adipose tissue are endocrine organs that release myokines and adipokines into the bloodstream, respectively. These cytokines regulate metabolic responses in a variety of tissues, including skeletal muscle and adipose tissue. However, the intricate mechanisms underlying adipose-muscle crosstalk in age-related metabolic diseases are not fully understood. Recent exciting evidence suggests that myokines act to control adipose tissue functions, including lipolysis, browning, and inflammation, whereas adipokines mediate the beneficial actions of adipose tissue in the muscle, such as glucose uptake and metabolism. In this review, we assess the mechanisms of adipose-muscle crosstalk in age-related disorders and propose that the adipokines adiponectin and spexin, as well as the myokines irisin and interleukin-6 (IL-6), are crucial for maintaining the body's metabolic balance in age-related metabolic disorders. In addition, these changes of adipose-muscle crosstalk in response to exercise or dietary flavonoid consumption are part of the mechanisms of both functions in the remission of age-related metabolic disorders. A better understanding of the intricate relationships between adipose tissue and skeletal muscle could lead to more potent therapeutic approaches to prolong life and prevent age-related metabolic diseases.
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“Adiponectin is released from the AT and plays a key role in regulating metabolic functioning of the SM, including enhanced mitochondrial function, Glucose Transporter 4 (GLUT4) translocation (to improve glucose uptake), and fatty acid oxidation [56].”
From Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management (2025) · cites this paper as [56]
In the citing paper
“Disruption in these signaling pathways contributes to the pathogenesis of sarcopenic obesity, which Fang et al. describe as a convergence of high fat mass and declining muscle function with aging”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [92]
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- Petersen, 2005, Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro, Am. J. Physiol. Endocrinol. Metab., 288, E155, 10.1152/ajpendo.00257.2004 · DOI · Paper page
- Yang, 2016, Swimming intervention mitigates HFD-induced obesity of rats through PGC-1α-irisin pathway, Eur. Rev. Med Pharm. Sci., 20, 2123
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Glucagon-like peptide-1 receptor agonists and muscle mass effects
Ceasovschih, A., Asaftei, A., Lupo, M. G., Kotlyarov, S., Bartušková, H., Balta, A., Sorodoc, V., Sorodoc, L., & Banach, M. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107927 · Cited by 64
Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44
“Disruption in these signaling pathways contributes to the pathogenesis of sarcopenic obesity, which Fang et al. describe as a convergence of high fat mass and declining muscle function with aging [92].”
Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management
Barber, T. M., Kabisch, S., Pfeiffer, A. F. H., & Weickert, M. O. (2025) · Metabolites · doi:10.3390/metabo15020085 · Cited by 19
“In addition to the aging-related decline in SM mass and function, there are other obesity-related factors that can diminish SM mass through the effects of adipokines and cytokines outlined in the last section.”
InfluentialHerouvi, D., Vlachopapadopoulou, E. A., Vakaki, M., Gouriotis, D., Marmarinos, A., Kalpia, C., Kossiva, L., Tsolia, M., & Karavanaki, K. (2024) · Endocrine · doi:10.1007/s12020-024-04139-x · Cited by 5
Metadata
- Authors
- Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z.
- Affiliations
- Nanjing University of Chinese Medicine (CN)
- Yangzhou University (CN)
- Corresponding author
- Fang, Penghua
- Shang, Wenbin
- Zhang, Zhenwen
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2023-02
- Volume
- 84
- Pages
- 101829
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W4312085090
- Cited by
- 62
- References
- 201
- Citations by year
- 2026: 18 · 2025: 20 · 2024: 16 · 2023: 8
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Administration of Traditional Chinese Medicine of Jilin Province (YB2020087)
- National Natural Science Foundation of China (81803792)
- Nanjing University of Chinese Medicine (NZY81803792)
- Priority Academic Program Development of Jiangsu Higher Education Institutions (ZYX03KF058)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- myokines, adipokines, adiponectin, spexin, irisin, interleukin-6, obesity, type 2 diabetes, skeletal muscle glucose uptake, insulin sensitivity, lipolysis, brown adipose tissue browning, inflammation, physical activity, dietary flavonoids, aging
- MeSH terms
- Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Obesity, Muscle, Skeletal, Adipokines
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