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FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

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Crosstalk between obesity, diabetes, and alzheimer’s disease: Introducing quercetin as an effective triple herbal medicine

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Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice

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Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes

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Overexpression of Adiponectin Targeted to Adipose Tissue in Transgenic Mice: Impaired Adipocyte Differentiation

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Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults

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Exercise-induced myokines in health and metabolic diseases

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Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling

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Decreased Adipose Tissue Oxygenation Associates with Insulin Resistance in Individuals with Obesity

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Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise

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Serum Levels of Spexin and Kisspeptin Negatively Correlate With Obesity and Insulin Resistance in Women

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Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells

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Acute effects of high-intensity interval training and moderate-intensity continuous exercise on BDNF and irisin levels and neurocognitive performance in late middle-aged and older adults

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Metabolic effects of interleukin-6 in human splanchnic and adipose tissue

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Skeletal muscle adiponectin induction in obesity and exercise

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Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2

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Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism

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The role of interleukin-6 in glucose homeostasis and lipid metabolism

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Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor

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Regulation of Hepatocellular Fatty Acid Uptake in Mouse Models of Fatty Liver Disease with and without Functional Leptin Signaling: Roles of NfKB and SREBP-1C and the Effects of Spexin

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Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population

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Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity

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Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

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Decreased Circulating Levels of Spexin in Obese Children

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Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle

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Lower irisin level in patients with type 2 diabetes mellitus: A case‐control study and meta‐analysis

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New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity.

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Adiponectin Corrects High-Fat Diet–Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis

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Quercetin enhances adiponectin secretion by a PPAR-γ independent mechanism

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Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

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Circulating Irisin Concentrations in Rat Models of Thyroid Dysfunction — Effect of Exercise

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Implication of Circulating Irisin Levels with Brown Adipose Tissue and Sarcopenia in Humans

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Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass

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Spexin: A novel regulator of adipogenesis and fat tissue metabolism

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Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice

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Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats

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Effects of 12 Weeks Resistance Training on Serum Irisin in Older Male Adults

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Skeletal muscle interleukin-6 and tumor necrosis factor-α release in healthy subjects and patients with type 2 diabetes at rest and during exercise

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Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies

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Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice

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Aerobic and resistance training effects compared to aerobic training alone in obese type 2 diabetic patients on diet treatment

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Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat

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Interleukin-6 released from differentiating human beige adipocytes improves browning

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Adiponectin, Leptin, and Chemerin in Elderly Patients with Type 2 Diabetes Mellitus: A Close Linkage with Obesity and Length of the Disease

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A randomized controlled trial on the effects of 12 weeks of aerobic, resistance, and combined exercises training on the serum levels of nesfatin-1, irisin-1 and HOMA-IR.

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Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

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Decreased Spexin Levels in Patients with Type 1 and Type 2 Diabetes

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Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes

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Fndc5 loss‐of‐function attenuates exercise‐induced browning of white adipose tissue in mice

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Effects of exercise on adiponectin and adiponectin receptor levels in rats

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Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men

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30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status

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Adipose tissue insulin action and IL-6 signaling after exercise in obese mice

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Influence of acute aerobic exercise on adiponectin oligomer concentrations in middle-aged abdominally obese men

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Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization

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Galanin peptide family regulation of glucose metabolism

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Disordered metabolism in mice lacking irisin

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Spexin Levels Are Associated with Metabolic Syndrome Components

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Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

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“Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice”

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Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight

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Adiponectin and Skeletal Muscle

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The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype

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Exercise Training Modulates Adipokine Dysregulations in Metabolic Syndrome

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Circulating Spexin Levels Negatively Correlate With Age, BMI, Fasting Glucose, and Triglycerides in Healthy Adult Women

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Combination of melatonin and irisin ameliorates lipopolysaccharide‐induced cardiac dysfunction through suppressing the Mst1–JNK pathways

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Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity

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Circulating Spexin Decreased and Negatively Correlated with Systemic Insulin Sensitivity and Pancreatic β Cell Function in Obese Children

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Quercetin regulates skeletal muscle fiber type switching via adiponectin signaling

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Irisin is a predictor of sarcopenic obesity in type 2 diabetes mellitus

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Correlation between manual muscle strength and interleukin-6 (IL-6) plasma levels in elderly community-dwelling women

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Exercise training performed simultaneously to a high-fat diet reduces the degree of insulin resistance and improves adipoR1-2/APPL1 protein levels in mice

de Farias, J., Maggi, R. M., Tromm, C. B., da Silva, L. A., Luciano, T. F., Marques, S. M. S., Lira, F. S., de Souza, C., & Pinho, R. A. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-134 · Cited by 45

Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: An in vivo and in vitro study

Pruszyńska‐Oszmałek, E., Sassek, M., Szczepankiewicz, D., Nowak, K. W., & Kolodziejski, P. A. (2020) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2020.113615 · Cited by 45

Lower levels of irisin in patients with type 2 diabetes mellitus: A meta-analysis

Song, R., Zhao, X., Zhang, D., Wang, R., & Feng, Y. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108788 · Cited by 45

Effects of high-intensity interval training on mitochondrial supercomplex assembly and biogenesis, mitophagy, and the AMP-activated protein kinase pathway in the soleus muscle of aged female rats

Han, C., Lu, P., & Yan, S.-Z. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111648 · Cited by 44

Irisin response to acute moderate intensity exercise and high intensity interval training in youth of different obesity statuses: A randomized crossover trial

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Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2

El‐Saka, M. H., Gheit, R. E. A. E., Saadany, A. A. E., Alghazaly, G. M., Marea, K. E., & Madi, N. M. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1887265 · Cited by 43

Blocking endogenous IL-6 impairs mobilization of free fatty acids during rest and exercise in lean and obese men

Trinh, B., Peletier, M. C., Simonsen, C., Plomgaard, P., Karstoft, K., Pedersen, B. K., van Hall, G., & Ellingsgaard, H. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100396 · Cited by 42

Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile

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Metabolic functions of flavonoids: From human epidemiology to molecular mechanism

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Peripheral IL-6/STAT3 signaling promotes beiging of white fat

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Irisin regulates thermogenesis and lipolysis in 3T3-L1 adipocytes

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Serum irisin level is independent of sarcopenia and related muscle parameters in older adults

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Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor

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The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells

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Effect of Exercise Training on Spexin Level, Appetite, Lipid Accumulation Product, Visceral Adiposity Index, and Body Composition in Adults With Type 2 Diabetes

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Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin

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Low levels of spexin and adiponectin may predict insulin resistance in patients with non-alcoholic fatty liver

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Favorable Changes in Fasting Glucose in a 6-month Self-Monitored Lifestyle Modification Programme Inversely Affects Spexin Levels in Females with Prediabetes

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Are spexin levels associated with metabolic syndrome, dietary intakes and body composition in children?

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Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity

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Superiority of the Non-Glycosylated Form over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight against Insulin Resistance

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Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro—The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo

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Irisin has no effect on lipolysis in 3T3-L1 adipocytes or fatty acid metabolism in HepG2 hepatocytes

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Delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubbles improves insulin sensitivity and whole body glucose homeostasis

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Exercise-mediated IL-6 signaling occurs independent of inflammation and is amplified by training in mouse adipose tissue

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Development of metabolic dysfunction in mice lacking chemerin

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Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2

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Emerging central and peripheral actions of spexin in feeding behavior, leptin resistance and obesity

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Regular Swimming Exercise Attenuated Neuroma Pain in Rats: Involvement of Leptin and Adiponectin

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Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults

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Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men

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Serum Spexin is Correlated with Lipoprotein(a) and Androgens in Female Adolescents

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Exercise training rescues adipose tissue spexin expression and secretion in diet-induced obese mice

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Does exercise during a ketogenic diet effectively alter appetite sensation, appetite-regulating hormones, and body composition?

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Mutation of spexin2 promotes feeding, somatic growth, adiposity, and insulin resistance in zebrafish

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Effects of Quercetin and Coenzyme Q10 on Biochemical, Molecular, and Morphological Parameters of Skeletal Muscle in Trained Diabetic Rats

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Temporal specificity of IL-6 knockout in enhancing the thermogenic capability of brown adipose tissue

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Hypothesis: The role of quercetin in adipokine biology

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Are irisin levels associated with inflammation and insulin resistance in patients with moderate-to-severe psoriasis?

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Glucagon-like peptide-1 receptor agonists and muscle mass effects

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Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging

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Optimised Skeletal Muscle Mass as a Key Strategy for Obesity Management

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Relation of Serum Irisin Levels with Adiposity, Components of Metabolic Syndrome and Carotid Intima Media Thickness in Prepubertal Children with Obesity: A Cross-Sectional Study

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Proteomic analysis of secreted proteins from skeletal muscle cells during differentiation

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Muscle-to-organ cross talk mediated by myokines

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Myokines in insulin resistance and type 2 diabetes

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The Effect of Physical Activity on the Secretory Function of Muscles and Bone Tissue in Humans

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Skeletal muscle as a gene regulatory endocrine organ

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