The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis
Abstract
PURPOSE: This multicenter, double-blind clinical trial evaluated and compared the efficacy and safety of PRGF-Endoret (BTI Biotechnology Institute, Vitoria-Gasteiz, Spain), an autologous biological therapy for regenerative purposes, versus hyaluronic acid (HA) as a short-term treatment for knee pain from osteoarthritis. METHODS: We randomly assigned 176 patients with symptomatic knee osteoarthritis to receive infiltrations with PRGF-Endoret or with HA (3 injections on a weekly basis). The primary outcome measure was a 50% decrease in knee pain from baseline to week 24. As secondary outcomes, we also assessed pain, stiffness, and physical function using the Western Ontario and McMaster Universities Osteoarthritis Index; the rate of response using the criteria of the Outcome Measures for Rheumatology Committee and Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative (OMERACT-OARSI); and safety. RESULTS: The mean age of the patients was 59.8 years, and 52% were women. Compared with the rate of response to HA, the rate of response to PRGF-Endoret was 14.1 percentage points higher (95% confidence interval, 0.5 to 27.6; P = .044). Regarding the secondary outcome measures, the rate of response to PRGF-Endoret was higher in all cases, although no significant differences were reached. Adverse events were mild and evenly distributed between the groups. CONCLUSIONS: Plasma rich in growth factors showed superior short-term results when compared with HA in a randomized controlled trial, with a comparable safety profile, in alleviating symptoms of mild to moderate osteoarthritis of the knee. LEVEL OF EVIDENCE: Level I, randomized controlled multicenter trial.
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Guccione, A. A., Felson, D. T., Anderson, J. J., Anthony, J. M., Zhang, Y., Wilson, P. W., Kelly-Hayes, M., Wolf, P. A., Kreger, B. E., & Kannel, W. B. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.3.351 · Cited by 1,584
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Cited by
Platelet-rich plasma for managing pain and inflammation in osteoarthritis
Andia, I., & Maffulli, N. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.141 · Cited by 465
Dai, W.-L., Zhou, A.-G., Zhang, H., & Zhang, J. (2017) · Arthroscopy: The Journal of Arthroscopic & Related Surgery · doi:10.1016/j.arthro.2016.09.024 · Cited by 444
Ayhan, E. (2014) · World Journal of Orthopedics · doi:10.5312/wjo.v5.i3.351 · Cited by 441
Belk, J. W., Kraeutler, M. J., Houck, D. A., Goodrich, J. A., Dragoo, J. L., & McCarty, E. C. (2021) · The American Journal of Sports Medicine · doi:10.1177/0363546520909397 · Cited by 432
Smith, P. A. (2016) · The American Journal of Sports Medicine · doi:10.1177/0363546515624678 · Cited by 293
Metadata
- Authors
- Sánchez, M., Fiz, N., Azofra, J., Usabiaga, J., Aduriz Recalde, E., Garcia Gutierrez, A., Albillos, J., Gárate, R., Aguirre, J. J., Padilla, S., Orive, G., & Anitua, E.
- Venue
- Arthroscopy: The Journal of Arthroscopic & Related Surgery
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 28
- Issue
- 8
- Pages
- 1070-1078
- ISSN
- 0749-8063 (ISSN-L)
- OpenAlex
- W2108738802
- Cited by
- 403
- References
- 30
- FWCI
- 32.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Sánchez, M., Fiz, N., Azofra, J., Usabiaga, J., Aduriz Recalde, E., Garcia Gutierrez, A., Albillos, J., Gárate, R., Aguirre, J. J., Padilla, S., Orive, G., & Anitua, E. (2012). A Randomized Clinical Trial Evaluating Plasma Rich in Growth Factors (PRGF-Endoret) Versus Hyaluronic Acid in the Short-Term Treatment of Symptomatic Knee Osteoarthritis. Arthroscopy: The Journal of Arthroscopic & Related Surgery. https://doi.org/10.1016/j.arthro.2012.05.011
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