The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cartilage homeostasis in health and rheumatic diseases
Open accessAbstract
As the cellular component of articular cartilage, chondrocytes are responsible for maintaining in a low-turnover state the unique composition and organization of the matrix that was determined during embryonic and postnatal development. In joint diseases, cartilage homeostasis is disrupted by mechanisms that are driven by combinations of biological mediators that vary according to the disease process, including contributions from other joint tissues. In osteoarthritis (OA), biomechanical stimuli predominate with up-regulation of both catabolic and anabolic cytokines and recapitulation of developmental phenotypes, whereas in rheumatoid arthritis (RA), inflammation and catabolism drive cartilage loss. In vitro studies in chondrocytes have elucidated signaling pathways and transcription factors that orchestrate specific functions that promote cartilage damage in both OA and RA. Thus, understanding how the adult articular chondrocyte functions within its unique environment will aid in the development of rational strategies to protect cartilage from damage resulting from joint disease. This review will cover current knowledge about the specific cellular and biochemical mechanisms that regulate cartilage homeostasis and pathology.
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Cites
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.
Pettit, A. R., Ji, H., von Stechow, D., Müller, R., Goldring, S. R., Choi, Y., Benoist, C., & Gravallese, E. M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63016-7 · Cited by 807
Biological markers in osteoarthritis
Rousseau, J.-C., & Delmas, P. D. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0508 · Cited by 237
Type II collagen markers in osteoarthritis: what do they indicate?
Henrotin, Y., Addison, S., Kraus, V., & Deberg, M. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32829fb3b5 · Cited by 108
Chondroitin Sulfate Perlecan Enhances Collagen Fibril Formation
Kvist, A. J., Johnson, A. E., Mörgelin, M., Gustafsson, E., Bengtsson, E., Lindblom, K., Aszódi, A., Fässler, R., Sasaki, T., Timpl, R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607892200 · Cited by 102
Osteoarthritis: Aging of Matrix and Cells - Going for a Remedy
Aigner, T., Haag, J., Martin, J., & Buckwalter, J. (2007) · Current Drug Targets · doi:10.2174/138945007779940070 · Cited by 85
Cited by
Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,076
Self-citationOsteoarthritis: pathogenic signaling pathways and therapeutic targets
Yao, Q., Wu, X., Tao, C., Gong, W., Chen, M., Qu, M., Zhong, Y., He, T., Chen, S., & Xiao, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01330-w · Cited by 1,194
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
Goldring, M. B., & Goldring, S. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05240.x · Cited by 932
Self-citationMicroRNA-140 plays dual roles in both cartilage development and homeostasis
Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Takemoto, F., Nakasa, T., Yamashita, S., et al. (2010) · Genes & Development · doi:10.1101/gad.1915510 · Cited by 660
Biomaterials for articular cartilage tissue engineering: Learning from biology
Armiento, A. R., Stoddart, M. J., Alini, M., & Eglin, D. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.021 · Cited by 579
Metadata
- Authors
- Goldring, M. B., & Marcu, K. B.
- Venue
- Arthritis Research & Therapy
- Published
- 2009
- Volume
- 11
- Issue
- 3
- Pages
- 224
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W2101471525
- Cited by
- 762
- References
- 5
- FWCI
- 21.14
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
