The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis
Open accessAbstract
Osteoarthritis (OA) is a complex "whole joint" disease pursued by inflammatory mediators, rather than purely a process of "wear and tear". Besides cartilage degradation, synovitis, subchondral bone remodeling, degeneration of ligaments and menisci, and hypertrophy of the joint capsule take parts in the pathogenesis. Pain is the hallmark symptom of OA, but the extent to which structural pathology in OA contributes to the pain experience is still not well known. For the knee OA, intraarticular (IA) injection (corticosteroids, viscosupplements, blood-derived products) is preferred as the last nonoperative modality, if the other conservative treatment modalities are ineffective. IA corticosteroid injections provide short term reduction in OA pain and can be considered as an adjunct to core treatment for the relief of moderate to severe pain in people with OA. IA hyaluronic acid (HA) injections might have efficacy and might provide pain reduction in mild OA of knee up to 24 wk. But for HA injections, the cost-effectiveness is an important concern that patients must be informed about the efficacy of these preparations. Although more high-quality evidence is needed, recent studies indicate that IA platelet rich plasma injections are promising for relieving pain, improving knee function and quality of life, especially in younger patients, and in mild OA cases. The current literature and our experience indicate that IA injections are safe and have positive effects for patient satisfaction. But, there is no data that any of the IA injections will cause osteophytes to regress or cartilage and meniscus to regenerate in patients with substantial and irreversible bone and cartilage damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,076
Hochberg, M. C., Altman, R. D., April, K. T., Benkhalti, M., Guyatt, G., McGowan, J., Towheed, T., Welch, V., Wells, G., & Tugwell, P. (2012) · Arthritis Care & Research · doi:10.1002/acr.21596 · Cited by 3,068
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
Kapoor, M., Martel-Pelletier, J., Lajeunesse, D., Pelletier, J.-P., & Fahmi, H. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.196 · Cited by 2,778
Dohan Ehrenfest, D. M., Rasmusson, L., & Albrektsson, T. (2009) · Trends in Biotechnology · doi:10.1016/j.tibtech.2008.11.009 · Cited by 2,008
The epidemiology and impact of pain in osteoarthritis
Neogi, T. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.03.018 · Cited by 1,730
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
Berenbaum, F. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.11.012 · Cited by 1,718
OARSI recommendations for the management of hip and knee osteoarthritis
Zhang, W., Nuki, G., Moskowitz, R. W., Abramson, S., Altman, R. D., Arden, N. K., Bierma-Zeinstra, S., Brandt, K. D., Croft, P., Doherty, M., et al. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.01.013 · Cited by 1,700
The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
Sellam, J., & Berenbaum, F. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.159 · Cited by 1,500
Autologous platelets as a source of proteins for healing and tissue regeneration
Anitua, E., Andia, I., Ardanza, B., Nurden, P., & Nurden, A. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0440 · Cited by 1,495
Inflammation in osteoarthritis
Goldring, M. B., & Otero, M. (2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e328349c2b1 · Cited by 1,462
Cited by
Knee osteoarthritis: pathophysiology and current treatment modalities
Mora, J. C., Przkora, R., & Cruz-Almeida, Y. (2018) · Journal of Pain Research · doi:10.2147/jpr.s154002 · Cited by 574
Recent advances in hyaluronic acid based therapy for osteoarthritis
Bowman, S., Awad, M. E., Hamrick, M. W., Hunter, M., & Fulzele, S. (2018) · Clinical and Translational Medicine · doi:10.1186/s40169-017-0180-3 · Cited by 288
Raeissadat, S. A., Ghazi Hosseini, P., Bahrami, M. H., Salman Roghani, R., Fathi, M., Gharooee Ahangar, A., & Darvish, M. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04017-x · Cited by 181
Nguyen, P. D., Tran, T. D.-X., Nguyen, H. T.-N., Vu, H. T., Le, P. T.-B., Phan, N. L.-C., Vu, N. B., Phan, N. K., & Van Pham, P. (2017) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0023 · Cited by 112
Dulic, O., Rasovic, P., Lalic, I., Kecojevic, V., Gavrilovic, G., Abazovic, D., Maric, D., Miskulin, M., & Bumbasirevic, M. (2021) · Medicina · doi:10.3390/medicina57111193 · Cited by 99
Metadata
- Authors
- Ayhan, E.
- Venue
- World Journal of Orthopedics
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 5
- Issue
- 3
- Pages
- 351
- ISSN
- 2218-5836 (ISSN-L)
- OpenAlex
- W2087363463
- Cited by
- 441
- References
- 120
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. https://app.cochat.ai/papers/10.5312/wjo.v5.i3.351
- The paper
- Ayhan, E. (2014). Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World Journal of Orthopedics. https://doi.org/10.5312/wjo.v5.i3.351
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
