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Cited by 11Origins and Evolution of LifeRNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Chemical evolution of RNA under hydrothermal conditions and the role of thermal copolymers of amino acids for the prebiotic degradation and formation of RNA

Kawamura, K., Nagahama, M., Kuranoue, K.·2005·Advances in Space Research
DOI 10.1016/j.asr.2005.04.071
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Abstract

The roles of thermal copolymers of amino acids (TCAA) were studied for the prebiotic degradation of RNA. A weak catalytic ability of TCAA consisted of Glu, L-Ala, L-Val, L-Glu, L-Asp, and optionally L-His was detected for the cleavage of the ribose phosphodiester bond of a tetranucleotide (5'-dCrCdGdG) in aqueous solution at 80 degees C. The rate constants of the disappearance of 5'-dCrCdGdG were determined in aqueous solutions using different pH buffer and TCAA. The degradation rates were enhanced 1.3-3.0 times in the presence of TCAA at pH 7.5 and 8.0 at 80 degrees C, while the hydrolysis of oligoguanylate (oligo(G)) was accelerated about 1.6 times at pH 8.0. A weak inhibitory activity for the cleavage of oligo(G) was detected in the presence of 0.055 M TCAA-Std. On the other hand, our recent study on the influences of TCAA for the template-directed reaction of oligo(G) on a polycytidylic acid template showed that TCAA has an acceleration activity for the degradation of the activated nucleotide monomer and an acceleration activity for the formation of G5' ppG capped oligo(G). This series of studies suggest that efficient and selective catalytic or inhibitory activities for either the degradation or formation of RNA under hydrothermal conditions could have hardly emerged from the simple thermal condensation products of amino acids. A scenario is going to be deduced on the chemical evolution of enzymatic activities and RNA molecules concerning hydrothermal earth conditions.

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  • Above 0°C, nucleotides hydrolyze quickly, making their accumulation hard in a hot-start scenario.

    “The rapid rates of hydrolysis of nucleotides at temperatures above 0 degrees C would make accumulation of these nucleotides difficult in a hot-start scenario (Kua and Bada 2011;Levy and Miller 1998;Kawamura et al. 2005).”

    From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Kawamura et al. 2005

  • Cellularity and cell membranes emerged prior to LUCA.

    “By extension, this evidence, together with analysis indicating that signal recognition particle RNA was present in LUCA, strongly supports cellularity and cell membranes emerging prior to LUCA (Gogarten and Taiz 1992;Kawamura et al. 2005;Hoeppner et al. 2012;Harris et al. 2003;Jékely 2006).”

    From Environmental Adaptation from the Origin of Life to the Last Universal Common Ancestor (2018) · cites this paper as Kawamura et al. 2005

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Authors
Kawamura, K., Nagahama, M., & Kuranoue, K.
Affiliations
Osaka Prefecture University (JP)
Corresponding author
Kawamura, K.
ORCID
Kawamura, K.
Venue
Advances in Space Research
Publisher
Elsevier BV
Published
2005
Volume
35
Issue
9
Pages
1626-1633
ISSN
0273-1177 (ISSN-L)
DOI
10.1016/j.asr.2005.04.071
OpenAlex
W2071990261
Cited by
11
References
50
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1
FWCI
0.97
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Advances in Space Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords
hydrothermal conditions, catalytic activity, inhibitory effect, prebiotic chemistry, enzyme origin
MeSH terms
Origin of Life, Amino Acids, Environment, Hot Temperature, Hydrolysis, Oligonucleotides, RNA, Water, Evolution, Chemical

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