Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 59

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

IL-6 and the acute phase response in murine atherosclerosis

Song, Li, Schindler, Christian·2004·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2004.06.018
Open this paper in CoChat — free account

Abstract

Numerous studies have implicated C-reactive protein (CRP) and the acute phase response (APR) in the development of atherosclerotic heart disease. Interleukin (IL)-6, which regulates both CRP expression and the APR, has also been identified as a risk factor for heart disease. To more directly evaluate the role of IL-6 in the development of atherosclerosis, IL-6 knockout mice were crossed with atherosclerosis prone LDL receptor (LDL-R) knockout mice. Lesion development was evaluated on Chow, Western type and Paigen diets. As anticipated, the Paigen diet stimulated the expression of APR genes in LDL-R[-/-] mice, but not IL-6[-/-]/LDL-R[-/-] mice. Despite this difference in acute phase response, only modest and statistically not significant differences were noted in the development of atherosclerotic lesions in LDL-R[-/-] and IL-6[-/-]/LDL-R[-/-] mice. These observations suggest that IL-6 and the acute phase response may not play as significant role in atherogenesis as other studies have indicated.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.atherosclerosis.2004.06.018

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 28

  1. Yudkin, 2000, Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?, Atherosclerosis, 148, 209, 10.1016/S0021-9150(99)00463-3 · DOI · Paper page
  2. Binder, 2002, Innate and acquired immunity in atherogenesis, Nat Med, 8, 1218, 10.1038/nm1102-1218 · DOI
  3. Blake, 2002, Inflammatory bio-markers and cardiovascular risk prediction, J Intern Med, 252, 283, 10.1046/j.1365-2796.2002.01019.x · DOI
  4. Ridker, 2000, C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women, N Engl J Med, 342, 836, 10.1056/NEJM200003233421202 · DOI · Paper page
  5. Luc, 2003, C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME study, Arterioscler Thromb Vasc Biol, 23, 1255, 10.1161/01.ATV.0000079512.66448.1D · DOI
  6. Rezaie-Majd, 2002, Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients, Arterioscler Thromb Vasc Biol, 22, 1194, 10.1161/01.ATV.0000022694.16328.CC · DOI
  7. Tomai, 2001, Unstable angina and elevated c-reactive protein levels predict enhanced vasoreactivity of the culprit lesion, Circulation, 104, 1471, 10.1161/hc3801.096354 · DOI
  8. Lindmark, 2001, Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy, JAMA, 286, 2107, 10.1001/jama.286.17.2107 · DOI
  9. Pradhan, 2001, C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus, JAMA, 286, 327, 10.1001/jama.286.3.327 · DOI · Paper page
  10. Torzewski, 2000, C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis, Arterioscler Thromb Vasc Biol, 20, 2094, 10.1161/01.ATV.20.9.2094 · DOI
  11. Seino, 1994, Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions, Cytokine, 6, 87, 10.1016/1043-4666(94)90013-2 · DOI
  12. Fattori, 1994, Defective inflammatory response in interleukin 6-deficient mice, J Exp Med, 180, 1243, 10.1084/jem.180.4.1243 · DOI · Paper page
  13. Alonzi, 2001, Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver, Mol Cell Biol, 21, 1621, 10.1128/MCB.21.5.1621-1632.2001 · DOI · Paper page
  14. Keidar, 2001, Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized LDL: a possible role for interleukin-6, Arterioscler Thromb Vasc Biol, 21, 1464, 10.1161/hq0901.095547 · DOI
  15. Huber, 1999, Interleukin-6 exacerbates early atherosclerosis in mice, Arterioscler Thromb Vasc Biol, 19, 2364, 10.1161/01.ATV.19.10.2364 · DOI · Paper page
  16. Elhage, 2001, Involvement of interleukin-6 in atherosclerosis but not in the prevention of fatty streak formation by 17beta-estradiol in apolipoprotein E-deficient mice, Atherosclerosis, 156, 315, 10.1016/S0021-9150(00)00682-1 · DOI
  17. Van Lenten, 2001, Oxidized phospholipids induce changes in hepatic paraoxonase and ApoJ but not monocyte chemoattractant protein-1 via interleukin-6, J Biol Chem, 276, 1923, 10.1074/jbc.M004074200 · DOI
  18. Paul, 2004, C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice, Circulation, 109, 647, 10.1161/01.CIR.0000114526.50618.24 · DOI
  19. Roselaar, 1998, Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo, J Lipid Res, 39, 1740, 10.1016/S0022-2275(20)32160-X · DOI
  20. Ishibashi, 1994, Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice, J Clin Invest, 93, 1885, 10.1172/JCI117179 · DOI
  21. Song, 2001, Lymphocytes are important in early atherosclerosis, J Clin Invest, 108, 251, 10.1172/JCI200111380 · DOI
  22. Lichtman, 1999, Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate, Arterioscler Thromb Vasc Biol, 19, 1938, 10.1161/01.ATV.19.8.1938 · DOI
  23. Vergnes, 2003, Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression, J Biol Chem, 278, 42774, 10.1074/jbc.M306022200 · DOI
  24. Gupta, 1997, IFN-γ potentiates atherosclerosis in apoE knock-out mice, J Clin Invest, 99, 2752, 10.1172/JCI119465 · DOI
  25. Nakashima, 1998, Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the ApoE-deficient mouse, Arterioscler Thromb Vasc Biol, 18, 842, 10.1161/01.ATV.18.5.842 · DOI
  26. Jain, 2003, Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes, Diab Care, 26, 2139, 10.2337/diacare.26.7.2139 · DOI
  27. Merat, 1999, Western-type diets induce insulin resistance and hyperinsulinemia in LDL receptor-deficient mice but do not increase aortic atherosclerosis compared with normoinsulinemic mice in which similar plasma cholesterol levels are achieved by a fructose-rich diet, Arterioscler Thromb Vasc Biol, 19, 1223, 10.1161/01.ATV.19.5.1223 · DOI
  28. Tomoda, 2000, Prognostic value of C-reactive protein levels within six hours after the onset of acute myocardial infarction, Am Heart J, 140, 324, 10.1067/mhj.2000.108244 · DOI

Cited by

See all 59

Metadata

Authors
Song, L., & Schindler, C.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2004-11
Volume
177
Issue
1
Pages
43-51
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2004.06.018
Cited by
59
References
2
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review