Cited by 198Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Do the Apoe −/− and Ldlr −/– Mice Yield the Same Insight on Atherogenesis?

Open access
Getz, Godfrey S., Reardon, Catherine A.·2016·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Murine models of atherosclerosis are useful for investigating the environmental and genetic influences on lesion formation and composition. Apoe −/− and Ldlr −/− mice are the 2 most extensively used models. The models differ in important ways with respect to the precise mechanism by which their absence enhances atherosclerosis, including differences in plasma lipoproteins. The majority of the gene function studies have utilized only 1 model, with the results being generalized to atherogenic mechanisms. In only a relatively few cases have studies been conducted in both atherogenic murine models. This review will discuss important differences between the 2 atherogenic models and will point out studies that have been performed in the 2 models where results are comparable and those where different results were obtained.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/atvbaha.116.306874

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Genetically modified ApoE-deficient mice have plasma cholesterol about five times higher than controls, and Ldlr-deficient mice have levels two to three times higher.

    “genetically modified ApoE- and Ldlr-deficient mice have higher plasma cholesterol levels (5 times and 2–3 times higher than controls, respectively) [114]”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Getz, G. S., & Reardon, C. A.
Affiliations
University of Chicago (US)
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
2016-09
Volume
36
Issue
9
Pages
1734-1741
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2471737803
Cited by
198
References
76
Citations by year
2026: 19 · 2025: 24 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 19 · 2020: 28 · 2019: 12 · 2018: 19 · 2017: 15 · 2016: 2
FWCI
9.70
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Heart, Lung, and Blood Institute (R01HL131028, R01HL088420)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
atherosclerosis, ApoE-deficient mice, Ldlr knockout mice, atherogenesis, serum lipoproteins, genetic susceptibility to atherosclerosis, model comparison
MeSH terms
Animals, Apolipoproteins E, Arteries, Coronary Artery Disease, Disease Models, Animal, Gene Expression Regulation, Lipoproteins, Lymphocytes, Macrophages, Phenotype, Receptors, LDL, Biomarkers, Mice, Knockout, Genetic Predisposition to Disease, Atherosclerosis, Plaque, Atherosclerotic, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review