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Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosis

Muendlein, Axel, Geller-Rhomberg, Simone, Saely, Christoph H., Winder, Thomas, Sonderegger, Gudrun, Rein, Philipp, Beer, Stefan, Vonbank, Alexander, Drexel, Heinz·2009·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2009.02.040
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Abstract

Objectives Recently, a significant impact of a new locus on chromosome 1p13.3 on serum LDL (low-density lipoprotein) cholesterol and clinical events of coronary artery disease (CAD) was described. Potential associations between variants on this locus and angiographically characterized coronary atherosclerosis are unknown. We therefore aimed at investigating the association of variants of locus 1p13.3 with coronary atherosclerosis. Methods We performed genotyping of variants rs599839, rs646776, and rs4970834 on chromosome 1p13.3 in a large cohort of 1610 consecutive Caucasian patients undergoing coronary angiography, where lesions of 50% or more were classified as significant. Results Compared to the homozygous common allele the rare alleles of variants rs599839, rs646776, and rs4970834 were significantly associated with decreased serum LDL cholesterol (132+/-40mg/dl vs. 125+/-36mg/dl, P=0.003, 132+/-40mg/dl vs. 124+/-36mg/dl, P Conclusions We conclude that chromosomal locus 1p13.3 is significantly associated with both, serum LDL cholesterol and coronary atherosclerotic lesions.

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Metadata

Authors
Muendlein, A., Geller-Rhomberg, S., Saely, C. H., Winder, T., Sonderegger, G., Rein, P., Beer, S., Vonbank, A., & Drexel, H.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2009-10
Volume
206
Issue
2
Pages
494-499
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2009.02.040
Cited by
38
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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