Cited by 164Oral microbiology and periodontitis researchCardiovascular Health and Disease PreventionDental Health and Care Utilization

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Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: A systematic review and meta-analysis

Orlandi, Marco, Suvan, Jeanie, Petrie, Aviva, Donos, Nikolaos, Masi, Stefano, Hingorani, Aroon, Deanfield, John, D’Aiuto, Francesco·2014·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2014.06.002

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Abstract

Objective This meta-analysis sought to investigate the association between carotid intima-media thickness (c-IMT), flow-mediated dilation (FMD) and periodontitis (PD) and to assess the effect of periodontal treatment on c-IMT and FMD.Methods Electronic database searching, hand searching of bibliographic references of included papers, related reviews, and journals in relation to oral, cardiovascular and ultrasound imaging field was carried out. Random effects meta-analyses were performed to investigate the association of co-existence of increased c-IMT, impaired FMD and PD with potential changes in these variables following periodontal intervention.Results 2009 citations and 101 full text articles were screened, with 35 meeting the review inclusion criteria of which 22 suitable for quantitative analysis. Meta-analysis demonstrated that the diagnosis of PD was associated with a mean increase in c-IMT of 0.08 mm (95% C.I. = 0.07-0.09) and a mean difference in FMD of 5.1% compared to controls (95% C.I. = 2.08-8.11%). A meta-analysis of the effects of periodontal treatment on FMD showed a mean improvement of 6.64% between test and control (95% C.I. = 2.83-10.44%).Conclusions This review demonstrated an association between increased c-IMT, impaired FMD and PD. Data from intervention studies suggested a beneficial effect of periodontal treatment on FMD indicating an improvement in endothelial function. The findings support investigation of periodontitis treatment on cardiovascular outcomes.

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Authors: Orlandi, M., Suvan, J., Petrie, A., Donos, N., Masi, S., Hingorani, A., Deanfield, J., & D’Aiuto, F.
Affiliations: University College London (GB)
Great Ormond Street Hospital (GB)
Corresponding author: Orlandi, Marco
ORCID: Orlandi, Marco
Petrie, Aviva
Donos, Nikolaos
Masi, Stefano
Hingorani, Aroon
Deanfield, John
D’Aiuto, Francesco
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2014-09
Volume: 236
Issue: 1
Pages: 39-46
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2014.06.002
OpenAlex: W1999544578
Cited by: 164
References: 62
Citations by year: 2026: 8 · 2025: 5 · 2024: 13 · 2023: 12 · 2022: 13 · 2021: 13 · 2020: 32 · 2019: 19 · 2018: 13 · 2017: 18 · 2016: 8 · 2015: 9 · 2014: 1
FWCI: 2.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
Funders: Medical Research Council (MR/K006584/1)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Keywords: periodontitis, carotid intima-media thickness, flow-mediated dilation, periodontal treatment, endothelial function, cardiovascular risk, oral health and cardiovascular disease
MeSH terms: Brachial Artery, Carotid Artery Diseases, Cross-Sectional Studies, Disease Susceptibility, Endothelium, Vascular, Humans, Periodontal Diseases, Periodontitis, Vasodilation, Comorbidity, Causality, Case-Control Studies, Hemorheology, Disease Progression, Controlled Clinical Trials as Topic, Plaque, Atherosclerotic, Carotid Intima-Media Thickness

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Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: A systematic review and meta-analysis

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