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Cited by 22Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionCancer-related gene regulation

ADMA and arginine derivatives in relation to non-invasive vascular function in the general population

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Baum, Christina, Johannsen, Silke S., Zeller, Tanja, Atzler, Dorothee, Ojeda, Francisco M., Wild, Philipp S., Sinning, Christoph R., Lackner, Karl J. +6 more·2016·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2015.10.101
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Abstract

Objective Nitric oxide produced from l-arginine is central to vascular homeostasis. Little is known about the relationship between arginine derivatives including asymmetric dimethylarginine (ADMA) and non-invasive vascular function measures in the general population.Approach and results In 5000 individuals (median age 56; 25th/75th percentile: 46, 65; 49% women) taking part in the population-based Gutenberg Health Study (Mainz area, Germany), we measured the relationship between the arginine derivatives asymmetric dimethylarginine (ADMA), N-monomethyl l-arginine (NMMA), symmetric dimethylarginine (SDMA) and l-arginine with flow-mediated dilation (FMD) and peripheral arterial tonometry (PAT). Weak bivariate correlations were observed between all measured arginine derivatives and vascular function measures, except of l-arginine and FMD and SDMA and PAT ratio. In multivariate adjusted linear regression analyses we could show statistically significant relationships between arginine derivatives and vascular function measures, which were influenced by age, sex and body mass index (BMI). Thus, a negative relationship between ADMA and FMD in females who were normal (beta: -0.095, P < 0.001) to overweight (beta: -0.071, P < 0.001) and a negative association of SDMA and FMD for middle-aged females was seen. The relationship between ADMA and PAT was negative for males who were normal (beta: -0.089, P < 0.001) to overweight (beta: -0.051, P = 0.007) and positive for obese females (beta: 0.073, P = 0.021).Conclusions We showed small but significant correlations between ADMA and related arginine derivatives and non-invasive vascular function measures representative of different vascular regions. The associations were markedly influenced by age, sex and BMI. These findings support a complex interplay of arginine metabolism and vascular function.

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  • More recent observations indicate that the ADMA/l-arginine ratios in plasma may be a better marker than either metabolite assessed independently.

    “More recent observations indicate that the ADMA/l-arginine ratios in plasma may be a better marker than either metabolite assessed independently (75, 589, 606, 790, 966).”

    From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [75]

  • Studies of a panel of l-arginine metabolites indicate some correlations, particularly for ADMA, but also the need to consider other factors such as age, sex, and body mass index.

    “Studies of a panel of l-arginine metabolites indicate some correlations, particularly for ADMA, but also the need to consider other factors such as age, sex, and body mass index (75, 771).”

    From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [75]

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Authors
Baum, C., Johannsen, S. S., Zeller, T., Atzler, D., Ojeda, F. M., Wild, P. S., Sinning, C. R., Lackner, K. J., Gori, T., Schwedhelm, E., Böger, R. H., Blankenberg, S., Münzel, T., & Schnabel, R. B.
Affiliations
  • Universität Hamburg (DE)
  • University of Oxford (GB)
  • University Medical Center of the Johannes Gutenberg University Mainz (DE)
  • University Medical Center Hamburg-Eppendorf (DE)
Corresponding author
Schnabel, Renate B.
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2016-01
Volume
244
Pages
149-156
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2015.10.101
OpenAlex
W2205362617
Cited by
21
References
33
Citations by year
2025: 2 · 2024: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 2
FWCI
2.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords
asymmetric dimethylarginine, arginine derivatives, L-NMMA, symmetric dimethylarginine, L-arginine, nitric oxide, vascular function, flow-mediated dilation, peripheral arterial tonometry, arginine metabolism, body mass index, sex differences, age effects, Gutenberg Health Study
MeSH terms
Adult, Aged, Arginine, Blood Flow Velocity, Brachial Artery, Cardiovascular Diseases, Cross-Sectional Studies, Enzyme Inhibitors, Female, Germany, Humans, Male, Middle Aged, Population Surveillance, Retrospective Studies, Vasodilation, Prevalence, Nitric Oxide Synthase

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