Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis
Abstract
Abstract—Nitric oxide (NO) was originally discovered as a vasodilator product of the endothelium. Over the last 15 years, this vascular mediator has been shown to have important antiplatelet actions as well. By activating guanylyl cyclase, inhibiting phosphoinositide 3-kinase, impairing capacitative calcium influx, and inhibiting cyclooxygenase-1, endothelial NO limits platelet activation, adhesion, and aggregation. Platelets are also an important source of NO, and this platelet-derived NO pool limits recruitment of platelets to the platelet-rich thrombus. A deficiency of bioactive NO is associated with arterial thrombosis in animal models, individuals with endothelial dysfunction, and patients with a deficiency of the extracellular antioxidant enzyme glutathione peroxidase-3. This enzyme catalyzes the reduction of hydrogen and lipid peroxides, which limits the availability of these reactive oxygen species to react with and inactivate NO. The complex biochemical reactions that underlie the function and inactivation of NO in the vasculature represent an important set of targets for therapeutic intervention for the prevention and treatment of arterial thrombotic disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NO has a vasodilating effect.
“NO has a vasodilating effect and inhibits platelet aggregation [63].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [63]
NO inhibits platelet aggregation.
“NO has a vasodilating effect and inhibits platelet aggregation [63].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [63]
Platelet activation is mediated by NO through the soluble guanylate cyclase (sGC) pathway.
“The activation of platelets is mediated by NO through the soluble guanylate cyclase (sGC) pathway.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
NO produced by eNOS contributes to the thromboresistant properties of the endothelial lining by inhibiting platelet activation.
“The NO produced by eNOS contributes to the thromboresistant properties of the endothelial lining of blood vessels by inhibiting platelet activation.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
cGMP increases cAMP indirectly through phosphodiesterase III, decreasing intracellular calcium.
“In addition, the cGMP increases cyclic adenosine monophosphate (cAMP) levels indirectly through phosphodiesterase III, which will also decrease the intracellular calcium concentration.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
NO-activated sGC reduces intracellular calcium, inhibits platelet PI3-kinase, and reduces affinity and number of fibrinogen binding sites on GPIIb/IIIa.
“The NO activated sGC ultimately results in reduced intracellular calcium, inhibition of platelet phosphoinositide 3-kinase (PI3), and reduced affinity as well as number of surface membrane fibrinogen binding sites on platelets (GPIIb/IIIa).117,121–126”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [121]
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744 · see citing works
Self-citationUpregulation of Endothelial Nitric Oxide Synthase by HMG CoA Reductase Inhibitors
Laufs, U., Fata, V. L., Plutzky, J., & Liao, J. K. (1998) · Circulation · doi:10.1161/01.cir.97.12.1129 · Cited by 1,837 · see citing works
ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91481-4 · Cited by 1,437 · see citing works
Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350 · see citing works
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238 · see citing works
Self-citationIgnarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,164 · see citing works
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11310.x · Cited by 813 · see citing works
Katsuki, S., Arnold, W. P., Mittal, C. K., & Murad, F. (1977) · PubMed · Cited by 701 · see citing works
Nitric oxide metabolism and breakdown
Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673 · see citing works
Chambers, I., Frampton, J., Goldfarb, P. S., Affara, N. A., McBain, W., & Harrison, P. R. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04350.x · Cited by 667 · see citing works
Mellion, B. T., Ignarro, L. J., Ohlstein, E. H., Pontecorvo, E., Hyman, A. L., & Kadowitz, P. (1981) · Blood · doi:10.1182/blood.v57.5.946.946 · Cited by 639 · see citing works
Endothelium‐dependent inhibition of platelet aggregation
Azuma, H., Ishikawa, M., & Sekizaki, S. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb10218.x · Cited by 532 · see citing works
Laufs, U., Gertz, K. R., Huang, P. L., Nickenig, G., Böhm, M., Dirnagl, U., & Endres, M. (2000) · Stroke · doi:10.1161/01.str.31.10.2442 · Cited by 389 · see citing works
Nitric oxide released from activated platelets inhibits platelet recruitment.
Freedman, J. E., Loscalzo, J., Barnard, M. R., Alpert, C. S., Keaney, J. F., & Michelson, A. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119540 · Cited by 388 · see citing works
Self-citationα-Tocopherol Inhibits Aggregation of Human Platelets by a Protein Kinase C–Dependent Mechanism
Freedman, J. E., Farhat, J. H., Loscalzo, J., & Keaney, J. F. (1996) · Circulation · doi:10.1161/01.cir.94.10.2434 · Cited by 311 · see citing works
Self-citationScharfstein, J., Keaney, J. F., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., & Loscalzo, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117480 · Cited by 288 · see citing works
Self-citationKurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S.-I., Fukui, Y., Ui, M., Hazeki, O., & Katada, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24252 · Cited by 260 · see citing works
Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol
Cooke, J. P., Stamler, J. S., Andon, N., Davies, P. F., McKinley, G., & Loscalzo, J. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.3.h804 · Cited by 257 · see citing works
Self-citationSULFHYDRYL REQUIREMENT FOR RELAXATION OF VASCULAR SMOOTH MUSCLE
Needleman, P., Jakschik, B. A., & Johnson, E. M. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29678-1 · Cited by 253 · see citing works
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.
Stamler, J. S., Mendelsohn, M. E., Amarante, P., Smick, D., Andon, N., Davies, P. F., Cooke, J. P., & Loscalzo, J. (1989) · Circulation Research · doi:10.1161/01.res.65.3.789 · Cited by 243 · see citing works
Self-citationZai, A., Rudd, M. A., Scribner, A. W., & Loscalzo, J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4890 · Cited by 234 · see citing works
Self-citationMaddipati, K. R., & Marnett, L. J. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45392-6 · Cited by 232 · see citing works
Marks, D. S., Vita, J. A., Folts, J. D., Keaney, J. F., Welch, G. N., & Loscalzo, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118328 · Cited by 230 · see citing works
Self-citationDeficient Platelet-Derived Nitric Oxide and Enhanced Hemostasis in Mice Lacking the NOSIII Gene
Freedman, J. E., Sauter, R., Battinelli, E. M., Ault, K. A., Knowles, C., Huang, P. L., & Loscalzo, J. (1999) · Circulation Research · doi:10.1161/01.res.84.12.1416 · Cited by 219 · see citing works
Self-citationInhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty
Ej, L., Brown, A. S., Belder, A. D., Smith, R. E. A., Martin, J., Wainwright, R. J., Thomas, M. R., Radomski, M. W., & Moncada, S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90287-9 · Cited by 202 · see citing works
Kucera, G. L., & Rittenhouse, S. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39361-5 · Cited by 201 · see citing works
Expression of constitutive endothelial nitric oxide synthase in human blood platelets
Sase, K., & Michel, T. M. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02191-k · Cited by 193 · see citing works
Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine.
Mendelsohn, M. E., O'Neill, S., George, D., & Loscalzo, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30619-1 · Cited by 191 · see citing works
Self-citationN-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.
Loscalzo, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112024 · Cited by 187 · see citing works
Self-citationPtasznik, A., Traynor‐Kaplan, A., & Bokoch, G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19969 · Cited by 176 · see citing works
An in vivo model of experimental arterial stenosis, intimal damage, and periodic thrombosis.
Folts, J. D. (1991) · PubMed · Cited by 175 · see citing works
Impaired Platelet Production of Nitric Oxide Predicts Presence of Acute Coronary Syndromes
Freedman, J. E., Ting, B., Hankin, B., Loscalzo, J., Keaney, J. F., & Vita, J. A. (1998) · Circulation · doi:10.1161/01.cir.98.15.1481 · Cited by 172 · see citing works
Self-citationDecreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis.
Freedman, J. E., Loscalzo, J., Benoit, S. E., Valeri, C. R., Barnard, M. R., & Michelson, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118522 · Cited by 171 · see citing works
Self-citationGlutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols.
Freedman, J. E., Frei, B. B., Welch, G. N., & Loscalzo, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118047 · Cited by 153 · see citing works
Self-citationAnnich, G. M., Meinhardt, J. P., Mowery, K. A., Ashton, B. A., Merz, S. I., Hirschl, R. B., Meyerhoff, M. E., & Bartlett, R. H. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004000-00001 · Cited by 152 · see citing works
Folts, J. D., Stamler, J. S., & Loscalzo, J. (1991) · Circulation · doi:10.1161/01.cir.83.6.2122 · Cited by 149 · see citing works
Self-citationTrepakova, E. S., Cohen, R. A., & Bolotina, V. M. (1999) · Circulation Research · doi:10.1161/01.res.84.2.201 · Cited by 135 · see citing works
Liu, Z., Rudd, M. A., Freedman, J. E., & Loscalzo, J. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37255-6 · Cited by 131 · see citing works
Self-citationPhosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets
Zhang, J., Zhang, J. C., Shattil, S. J., Cunningham, M. C., & Rittenhouse-Simmons, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6265 · Cited by 129 · see citing works
Shen, Q., Chu, F., & Newburger, P. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82146-9 · Cited by 123 · see citing works
Vascular oxidant stress: Molecular mechanisms and pathophysiological implications
Zalba, G., Beaumont, J., José, G. S., Fortuño, A., Fortuño, M. A., & Dı́ez, J. (2000) · Journal of Physiology and Biochemistry · doi:10.1007/bf03179777 · Cited by 123 · see citing works
Long-term Smoking Impairs Platelet-Derived Nitric Oxide Release
Ichiki, K., Ikeda, H., Haramaki, N., Ueno, T., & Imaizumi, T. (1996) · Circulation · doi:10.1161/01.cir.94.12.3109 · Cited by 117 · see citing works
Stamler, J. S., & Loscalzo, J. (1991) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(91)90686-4 · Cited by 107 · see citing works
Self-citationMinuz, P., Andrioli, G., Degan, M., Gaino, S., Ortolani, R., Tommasoli, R., Zuliani, V., Lechi, A., & Lechi, C. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.8.1248 · Cited by 102 · see citing works
Effects of nitric oxide/EDRF on platelet surface glycoproteins
Michelson, A. D., Benoit, S., Furman, M. I., Breckwoldt, W. L., Rohrer, M. J., Barnard, M. R., & Loscalzo, J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.5.h1640 · Cited by 101 · see citing works
Self-citationPigazzi, A., Heydrick, S. J., Folli, F. B., Benoit, S., Michelson, A. D., & Loscalzo, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14368 · Cited by 101 · see citing works
Self-citationBoulos, C., Jiang, H., & Balazy, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39223-7 · Cited by 92 · see citing works
Hydroxyl radical formation resulting from the interaction of nitric oxide and hydrogen peroxide
Nappi, A. J., & Vass, E. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(97)00125-6 · Cited by 91 · see citing works
Platelet Behaviour and Drugs Used in Cardiovascular Disease
Hampton, J. R., Harrison, M. J., Honour, A. J., & Mitchell, J. R. A. (1967) · Cardiovascular Research · doi:10.1093/cvr/1.2.101 · Cited by 89 · see citing works
Stamler, J. S., Vaughan, D. E., & Loscalzo, J. (1989) · Circulation Research · doi:10.1161/01.res.65.3.796 · Cited by 87 · see citing works
Self-citationKenet, G., Freedman, J., Shenkman, B., Regina, E., Brok-Simoni, F., Holzman, F., Vavva, F., Brand, N., Michelson, A., Trolliet, M., et al. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.8.2017 · Cited by 83 · see citing works
Self-citationBiphasic Activation of PKBα/Akt In Platelets
Banfíƈ, H., Downes, C. P., & Rittenhouse, S. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11630 · Cited by 81 · see citing works
Jahn, B., & Hänsch, G. M. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000235282 · Cited by 80 · see citing works
Nitric oxide release from resting human platelets
Zhou, Q., Hellermann, G., & Solomonson, L. P. (1995) · Thrombosis Research · doi:10.1016/0049-3848(95)90868-g · Cited by 80 · see citing works
Majka, M., Ratajczak, J., Kowalska, M. A., & Ratajczak, M. Z. (2000) · European Journal Of Haematology · doi:10.1034/j.1600-0609.2000.90112.x · Cited by 77 · see citing works
Nong, Z., Hoylaerts, M., Pelt, N. V., Collen, D., & Janssens, S. P. (1997) · Circulation Research · doi:10.1161/01.res.81.5.865 · Cited by 74 · see citing works
Tsikas, D., Ikic, M., Tewes, K. S., Raida, M., & Frölich, J. C. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01633-0 · Cited by 73 · see citing works
Characterization of the hydroperoxide-reducing activity of human plasma
Maddipati, K. R., Gasparski, C. M., & Marnett, L. J. (1987) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(87)90075-0 · Cited by 72 · see citing works
Effect of Nitric Oxide Synthase Inhibition on Bleeding Time in Humans
Simon, D. I., Stamler, J. S., Loh, E., Loscalzo, J., Francis, S. A., & Creager, M. A. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199508000-00022 · Cited by 68 · see citing works
Self-citationKader, K. N., Akella, R., Ziats, N. P., Lakey, L. A., Harasaki, H., Ranieri, J. P., & Bellamkonda, R. V. (2000) · Tissue Engineering · doi:10.1089/10763270050044425 · Cited by 65 · see citing works
The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces
Maalej, N. M., Albrecht, R. M., Loscalzo, J., & Folts, J. D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00687-1 · Cited by 62 · see citing works
Self-citationα‐Tocopherol and protein kinase C inhibition enhance platelet‐derived nitric oxide release
Freedman, J. E., Li, L., Sauter, R., & Keaney, J. F. (2000) · The FASEB Journal · doi:10.1096/fj.00-0360fje · Cited by 62 · see citing works
Platelet-Derived Nitric Oxide and Coronary Risk Factors
Ikeda, H., Takajo, Y., Murohara, T., Ichiki, K., Adachi, H., Haramaki, N., Katoh, A., & Imaizumi, T. (2000) · Hypertension · doi:10.1161/01.hyp.35.4.904 · Cited by 61 · see citing works
Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets
Chen, L., Salafranca, M. N., & Mehta, J. L. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.4.h1854 · Cited by 58 · see citing works
Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation
Stamler, J. S., Cunningham, M. C., & Loscalzo, J. (1988) · The American Journal of Cardiology · doi:10.1016/0002-9149(88)90962-9 · Cited by 54 · see citing works
Self-citationInhibition of Platelet Adhesion to Collagen by cGMP-Elevating Agents
Wu, C., Ko, F., & Teng, C. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.5998 · Cited by 43 · see citing works
Stagliano, N. E., Zhao, W., Prado, R., Dewanjee, M. K., Ginsberg, M. D., & Dietrich, W. D. (1997) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199711000-00007 · Cited by 39 · see citing works
Activation of PI 3-kinase by G protein βγ subunits
Hazeki, O., Okada, T., Kurosu, H., Takasuga, S., Suzuki, T., & Katada, T. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00106-4 · Cited by 38 · see citing works
S-Nitrosothiols Are Stored by Platelets and Released during Platelet–Neutrophil Interactions
Hirayama, A., Noronha-Dutra, A. A., Gordge, M. P., Neild, G. H., & Hothersall, J. S. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0208 · Cited by 36 · see citing works
Megson, I. L., Sogo, N., Mazzei, F. A., Butler, A. R., Walton, J. C., & Webb, D. J. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703731 · Cited by 35 · see citing works
Yanagi, S., Sada, K., Tohyama, Y., Tsubokawa, M., Nagai, K., Yonezawa, K., & Yamamura, H. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00329.x · Cited by 30 · see citing works
Anfossi, G., Russo, I., Massucco, P., Mattiello, L., Perna, P., Tassone, F., & Trovati, M. (1999) · Thrombosis Research · doi:10.1016/s0049-3848(99)00011-0 · Cited by 26 · see citing works
Fujimoto, Y., Tagano, S., Ogawa, K., Sakuma, S., & Fujita, T. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90087-4 · Cited by 21 · see citing works
Inbal, A., Gurevitz, O. T., Tamarin, I., Eskaraev, R., Chetrit, A., Novicov, I., Feldman, M., Varon, D., Eldar, M., & Loscalzo, J. (1999) · Blood · doi:10.1182/blood.v94.5.1693 · Cited by 16 · see citing works
Self-citationEffects of sodium selenite on in vitro interactions between platelets and endothelial cells
Ricetti, M. M., Guidi, G. C., Tecchio, C., Bellisola, G., Rigo, A., & Perona, G. (1999) · International Journal of Clinical & Laboratory Research · doi:10.1007/s005990050068 · Cited by 12 · see citing works
Gurevitz, O. T., Eldar, M., Skutelsky, E., Tamarin, I., Shenkman, B., Eskaraev, R., Castel, D., Loscalzo, J., & Inbal, A. (2000) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614136 · Cited by 11 · see citing works
Self-citationHorowitz, J. D. (2003) · Humana Press eBooks · doi:10.1385/1-59259-002-0:383 · Cited by 5 · see citing works
Jones, D. N. (1988) · Nature · doi:10.1038/336524a0 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Benavente-García, O., & Castillo, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8006568 · Cited by 1,158 · see citing works
Webb, A. J., Patel, N., Loukogeorgakis, S., Okorie, M., Aboud, Z., Misra, S., Rashid, R., Miall, P., Deanfield, J., Benjamin, N., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.103523 · Cited by 1,078 · see citing works
Krötz, F., Sohn, H., & Pohl, U. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000145574.90840.7d · Cited by 1,026 · see citing works
Endothelial Function: A Critical Determinant in Atherosclerosis?
Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851 · see citing works
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
Nofer, J., van der Giet, M., Tölle, M., Wolinska, I., Lipinski, K. V. W., Baba, H. A., Tietge, U. J. F., Gödecke, A., Ishii, I., Kleuser, B., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18004 · Cited by 694 · see citing works
Malaria biology and disease pathogenesis: insights for new treatments
Miller, L. H., Ackerman, H. C., Su, X., & Wellems, T. E. (2013) · Nature Medicine · doi:10.1038/nm.3073 · Cited by 578 · see citing works
Platelets in inflammation and thrombosis
Wagner, D. D., & Burger, P. C. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000095974.95122.ec · Cited by 570 · see citing works
Red blood cells express a functional endothelial nitric oxide synthase
Kleinbongard, P. (2005) · Blood · doi:10.1182/blood-2005-10-3992 · Cited by 566 · see citing works
The role of nitric oxide in cardiovascular diseases
NASEEM, K. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.003 · Cited by 557 · see citing works
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide
Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 489 · see citing works
Self-citationAssociation of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy
Shishehbor, M. H., Aviles, R. J., Brennan, M.-L., Fu, X., Goormastic, M., Pearce, G. L., Gokce, N., Keaney, J. F., Penn, M. S., Sprecher, D. L., et al. (2003) · JAMA · doi:10.1001/jama.289.13.1675 · Cited by 464 · see citing works
Atherosclerotic Vascular Disease Conference
Faxon, D. P., Fuster, V., Libby, P., Beckman, J. A., Hiatt, W. R., Thompson, R. W., Topper, J. N., Annex, B. H., Rundback, J. H., Fabunmi, R. P., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128520.37674.ef · Cited by 414 · see citing works
Self-citationVillagra, J., Shiva, S., Hunter, L. A., Machado, R. F., Gladwin, M. T., & Kato, G. J. (2007) · Blood · doi:10.1182/blood-2006-12-061697 · Cited by 384 · see citing works
Coronary Artery Disease: From Mechanism to Clinical Practice
Shao, C., Wang, J., Tian, J., & Tang, Y. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-2517-9_1 · Cited by 345 · see citing works
Nitric Oxide in Vascular Biology
Walford, G., & Loscalzo, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00345.x · Cited by 302 · see citing works
Self-citationIsenberg, J. S., Martin‐Manso, G., Maxhimer, J. B., & Roberts, D. D. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2561 · Cited by 301 · see citing works
Cattaruzza, M., Guzik, T. J., Słodowski, W., Pelvan, A., Becker, J., Halle, M., Buchwald, A. B., Channon, K. M., & Hecker, M. (2004) · Circulation Research · doi:10.1161/01.res.0000145359.47708.2f · Cited by 292 · see citing works
Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing
Gantenbein, K. V., & Kanaka-Gantenbein, C. (2021) · Nutrients · doi:10.3390/nu13061951 · Cited by 288 · see citing works
Lehnert, N., Kim, E., Dong, H. T., Harland, J. B., Hunt, A. P., Manickas, E. C., Oakley, K. M., Pham, J., Reed, G. C., & Alfaro, V. S. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00253 · Cited by 277 · see citing works
Nitric oxide in gastrointestinal health and disease
Shah, V. H., Lyford, G., Gores, G. J., & Farrugia, G. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.046 · Cited by 266 · see citing works
AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633
Chen, Z., Peng, I.-C., Sun, W., Su, M.-I., Hsu, P.-H., Fu, Y., Zhu, Y., DeFea, K., Pan, S., Tsai, M.-D., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.187567 · Cited by 264 · see citing works
Combating medical device fouling
Harding, J. L., & Reynolds, M. M. (2014) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.12.004 · Cited by 261 · see citing works
Rajagopalan, S., Somers, E. C., Brook, R. D., Kehrer, C., Pfenninger, D., Lewis, E., Chakrabarti, A. K., Richardson, B. C., Shelden, E. A., McCune, W. J., et al. (2004) · Blood · doi:10.1182/blood-2003-09-3198 · Cited by 253 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Mechanisms of Coronary Thrombosis in Cigarette Smoke Exposure
Barua, R. S., & Ambrose, J. A. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300154 · Cited by 243 · see citing works
Erythrocyte aggregation: Basic aspects and clinical importance
Baskurt, O. K., & Meiselman, H. J. (2013) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2012-1573 · Cited by 237 · see citing works
Vascular nitric oxide: formation and function
Loscalzo, J., & Jin (2010) · Journal of Blood Medicine · doi:10.2147/jbm.s7000 · Cited by 227 · see citing works
Self-citationYAMAMOTO, K., TAKESHITA, K., KOJIMA, T., TAKAMATSU, J., & SAITO, H. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.013 · Cited by 214 · see citing works
Madamanchi, N. R., Hakim, Z. S., & Runge, M. S. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01085.x · Cited by 212 · see citing works
Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease
Sen, S., McDonald, S. P., Coates, P. T., & Bonder, C. S. (2010) · Clinical Science · doi:10.1042/cs20100429 · Cited by 211 · see citing works
Rationale for the use of N ‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19
Flora, S. D., Balansky, R. M., & Maestra, S. L. (2020) · The FASEB Journal · doi:10.1096/fj.202001807 · Cited by 191 · see citing works
Nitric Oxide: A Guardian for Vascular Grafts?
de Mel, A., Murad, F., & Seifalian, A. M. (2011) · Chemical Reviews · doi:10.1021/cr200008n · Cited by 187 · see citing works
Glutathione Peroxidase-3 Deficiency Promotes Platelet-Dependent Thrombosis In Vivo
Jin, R. C., Mahoney, C. E., (Coleman) Anderson, L., Ottaviano, F., Croce, K., Leopold, J. A., Zhang, Y.-Y., Tang, S.-S., Handy, D. E., & Loscalzo, J. (2011) · Circulation · doi:10.1161/circulationaha.110.000034 · Cited by 186 · see citing works
Self-citationMechanisms of hemolysis‐associated platelet activation
Helms, C. C., Marvel, M., Zhao, W., Stahle, M. C., Vest, R., Kato, G. J., Lee, J. S., Christ, G. J., Gladwin, M. T., Hantgan, R. R., et al. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12422 · Cited by 185 · see citing works
Therapeutic strategies for sickle cell disease: towards a multi-agent approach
Telen, M. J., Malik, P., & Vercellotti, G. M. (2018) · Nature Reviews Drug Discovery · doi:10.1038/s41573-018-0003-2 · Cited by 184 · see citing works
Recent advances in electrocatalytic nitrite reduction
Zhang, X., Wang, Y., Wang, Y., Guo, Y., Xie, X., Yu, Y., & Zhang, B. (2022) · Chemical Communications · doi:10.1039/d1cc06690k · Cited by 184 · see citing works
Harris, K. F., & Matthews, K. A. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000116719.95524.e2 · Cited by 182 · see citing works
Update on lipids, inflammation and atherothrombosis
Storey, R. F., Vilahur, G., & Badimón, L. (2011) · Thrombosis and Haemostasis · doi:10.1160/ths10-11-0717 · Cited by 180 · see citing works
Rassaf, T., Kleinbongard, P., Preik, M., Dejam, A., Gharini, P., Lauer, T., Erckenbrecht, J., Duschin, A., Schulz, R., Heusch, G., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000035038.41739.cb · Cited by 178 · see citing works
Fischer, L. J., McIlhenny, S. E., Tulenko, T. N., Golesorkhi, N., Zhang, P., Larson, R. A., Lombardi, J. V., Shapiro, I. M., & DiMuzio, P. J. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.06.029 · Cited by 175 · see citing works
Formation of Dysfunctional High-Density Lipoprotein by Myeloperoxidase
Nicholls, S. J., Zheng, L., & Hazen, S. L. (2005) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2005.06.004 · Cited by 170 · see citing works
Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action
Taubert, D., Berkels, R., Grosser, N., Schröder, H., Gründemann, D., & Schömig, E. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705907 · Cited by 169 · see citing works
Thangaraju, K., Neerukonda, S. N., Katneni, U., & Buehler, P. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010153 · Cited by 164 · see citing works
Nitrite and nitrate chemical biology and signalling
DeMartino, A. W., Kim‐Shapiro, D. B., Patel, R. P., & Gladwin, M. T. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14484 · Cited by 156 · see citing works
Endothelial Dysfunction as an Early Sign of Atherosclerosis
Giannotti, G., & Landmesser, U. (2007) · Herz · doi:10.1007/s00059-007-3073-1 · Cited by 150 · see citing works
Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia
Burke, S. D., Zsengellér, Z. K., Khankin, E. V., Lo, A. S., Rajakumar, A., DuPont, J. J., McCurley, A., Moss, M. E., Zhang, D., Clark, C. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci83918 · Cited by 149 · see citing works
The Antithrombotic Effect of Angiotensin-(1-7) Involves Mas-Mediated NO Release from Platelets
Fraga-Silva, R. A., Pinheiro, S. V. B., Gonçalves, A. C. D. C., Alenina, N. V., Bäder, M., & Santos, R. A. S. (2008) · Molecular Medicine · doi:10.2119/2007-00073.fraga-silva · Cited by 146 · see citing works
Franchini, M. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.06.004 · Cited by 145 · see citing works
The clinical significance of endothelial dysfunction
Landmesser, U., & Drexler, H. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000179821.11071.79 · Cited by 142 · see citing works
Antithrombotic Therapy in the Elderly
Capodanno, D., & Angiolillo, D. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.04.063 · Cited by 142 · see citing works
Dietary Nitrate, Nitric Oxide, and Cardiovascular Health
Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141 · see citing works
Heitzer, T. A., Rudolph, V., Schwedhelm, E., Karstens, M., Sydow, K., Ortak, M., Tschentscher, P., Meinertz, T., Böger, R. H., & Baldus, S. E. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000225288.74170.dc · Cited by 141 · see citing works
Regulation of platelet granule exocytosis by S-nitrosylation
Morrell, C. N., Matsushita, K., Chiles, K. A., Scharpf, R. B., Yamakuchi, M., Mason, R. J. A., Bergmeier, W., Mankowski, J. L., Baldwin, W. M., Faraday, N. R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408310102 · Cited by 140 · see citing works
Raghavachari, N., Xu, X., Harris, A. B., Villagra, J. D., Logun, C., Barb, J. J., Solomon, M. A., Suffredini, A. F., Danner, R. L., Kato, G. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.658641 · Cited by 140 · see citing works
Therapeutic gas delivery via microbubbles and liposomes
Fix, S. M., Borden, M. A., & Dayton, P. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.04.027 · Cited by 137 · see citing works
ACE2 Activation Promotes Antithrombotic Activity
Fraga-Silva, R. A., Sorg, B. S., Wankhede, M., deDeugd, C. M., Jun, J. Y., Baker, M. B., Li, Y., Castellano, R. K., Katovich, M. J., Raizada, M. K., et al. (2010) · Molecular Medicine · doi:10.2119/molmed.2009.00160 · Cited by 133 · see citing works
Kalinowski, L., Matys, T., Chabielska, E., Buczko, W., & Maliñski, T. (2002) · Hypertension · doi:10.1161/01.hyp.0000034745.98129.ec · Cited by 133 · see citing works
Inhaled nitric oxide therapy in adults: European expert recommendations
Germann, P., Braschi, A., Rocca, G. D., Dinh‐Xuan, A. T., Falke, K. J., FROSTELL, C. G., Gustafsson, L. E., Hervé, P., Jolliet, P., Kaisers, U. X., et al. (2005) · Intensive Care Medicine · doi:10.1007/s00134-005-2675-4 · Cited by 130 · see citing works
Wang, Q., & Zennadi, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124259 · Cited by 124 · see citing works
Radiation as a Risk Factor for Cardiovascular Disease
Baker, J. E., Moulder, J. E., & Hopewell, J. W. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3742 · Cited by 123 · see citing works
Ivanovski, O., Szumilak, D., Nguyen‐Khoa, T., Ruellan, N., Phan, O., Lacour, B., Descamps‐Latscha, B., Dreeke, T. B., & Massy, Z. A. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00332.x · Cited by 117 · see citing works
Gong, G., Yuan, Q., Huang, W. Q., Zhou, S., Yang, X., & Li, D. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.11.028 · Cited by 116 · see citing works
Sphingosine-1-phosphate and modulation of vascular tone
Igarashi, J., & Michel, T. M. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp064 · Cited by 115 · see citing works
Velmurugan, S., Kapil, V., Ghosh, S. M., Davies, S., McKnight, A., Aboud, Z., Khambata, R. S., Webb, A. J., Poole, A., & Ahluwalia, A. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.031 · Cited by 114 · see citing works
Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works
Nitric oxide insufficiency and atherothrombosis
Voetsch, B., Jin, R. C., & Loscalzo, J. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0675-z · Cited by 114 · see citing works
Self-citationParra, A., Kreiter, K. T., Williams, S. E. I., Sciacca, R. R., Mack, W. J., Naidech, A. M., Commichau, C. S., Fitzsimmons, B., Janjua, N. A., Mayer, S. A., et al. (2005) · Neurosurgery · doi:10.1227/01.neu.0000153925.96889.8a · Cited by 114 · see citing works
Anticoagulation for Percutaneous Ventricular Assist Device-Supported Cardiogenic Shock
Vandenbriele, C., Arachchillage, D. J., Frederiks, P., Giustino, G., Gorog, D. A., Gramegna, M., Janssens, S. P., Meyns, B. P., Polzin, A., Scandroglio, M., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.052 · Cited by 113 · see citing works
Redox Control of Platelet Function
Essex, D. W. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2322 · Cited by 112 · see citing works
Fleser, P. S., Nuthakki, V. K., Malinzak, L. E., Callahan, R. E., Seymour, M. L., Reynolds, M. M., Merz, S. I., Meyerhoff, M. E., Bendick, P. J., Zelenock, G. B., et al. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.07.007 · Cited by 110 · see citing works
Ovechkin, A. V., Lominadze, D. G., Sedoris, K. C., Robinson, T., Tyagi, S. C., & Roberts, A. M. (2007) · Archives of Physiology and Biochemistry · doi:10.1080/13813450601118976 · Cited by 110 · see citing works
Nitric oxide and its relationship to thrombotic disorders
Freedman, J. E., & Loscalzo, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00180.x · Cited by 109 · see citing works
Self-citationvan Haperen, R., de Waard, M., van Deel, E. D., Mees, B., Kutryk, M. B. J., van Aken, T., Hamming, J. F., Grosveld, F. G., Duncker, D. J., & de Crom, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209477200 · Cited by 108 · see citing works
Li, S.-J., Zhou, D.-Y., Li, Y., Liu, H., Wu, P., Ouyang, J., Jiang, W., & Li, C. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00567 · Cited by 107 · see citing works
An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect
Fraga-Silva, R. A., Costa-Fraga, F. P., Sousa, F. B. D., Alenina, N. V., Bäder, M., Sinisterra, R. D., & Santos, R. A. S. (2011) · Clinics · doi:10.1590/s1807-59322011000500021 · Cited by 107 · see citing works
Gong, G., Yuan, Q., Huang, W. Q., Zhou, S. W., Wu, X., Yang, X., Zhao, Y., & Li, D. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.02.005 · Cited by 105 · see citing works
Historical perspective and future directions in platelet research
Coller, B. S. (2011) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2011.04356.x · Cited by 103 · see citing works
Russo, G., Leopold, J. A., & Loscalzo, J. (2002) · Vascular Pharmacology · doi:10.1016/s1537-1891(02)00250-1 · Cited by 103 · see citing works
Self-citationThiol Isomerases in Thrombus Formation
Furie, B., & Flaumenhaft, R. C. (2014) · Circulation Research · doi:10.1161/circresaha.114.301808 · Cited by 102 · see citing works
Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly
Ashley C, T., Mayank, A., & Nathan S, B. (2012) · Journal of Geriatric Cardiology · doi:10.3724/sp.j.1263.2011.00230 · Cited by 101 · see citing works
Glutamate mediates platelet activation through the AMPA receptor
Morrell, C. N., Sun, H., Ikeda, M., Béïque, J.-C., Swaim, A. M., Mason, E., Martin, T. V., McKnight, L. E., Gözen, O., Ampagoomian, D., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071474 · Cited by 100 · see citing works
Redox-dependent impairment of vascular function in sickle cell disease
Aslan, M., & Freeman, B. Α. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.014 · Cited by 96 · see citing works
Wang, H., Li, L., Jian-gang, J., Wang, Y., Lu, Z. Y., Bradbury, J. A., Lih, F. B., Wang, D. W., & Zeldin, D. C. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052787 · Cited by 96 · see citing works
Tryptophan-Derived Uremic Toxins and Thrombosis in Chronic Kidney Disease
Addi, T., Dou, L., & Burtey, S. (2018) · Toxins · doi:10.3390/toxins10100412 · Cited by 95 · see citing works
Sane, D. C., McKee, S., Malinin, A. I., & Serebruany, V. L. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02718-2 · Cited by 95 · see citing works
Antithrombotic activity of TNF-α
Cambien, B., Bergmeier, W., Saffaripour, S., Mitchell, H. A., & Wagner, D. D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19284 · Cited by 95 · see citing works
Pharmacological Modulation of Platelet Function in Hypertension
Blann, A. D., Nadar, S. K., & Lip, G. Y. H. (2003) · Hypertension · doi:10.1161/01.hyp.0000077901.84467.e1 · Cited by 94 · see citing works
Sugiyama, T., Levy, B. D., & Michel, T. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809295200 · Cited by 94 · see citing works
Koo, K., Lee, J. S., Lee, Y. J., Kim, K., Yoo, J. J., & Kim, H. J. (2006) · Journal of Orthopaedic Research® · doi:10.1002/jor.20164 · Cited by 93 · see citing works
The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress
Scribner, A. W., Loscalzo, J., & Claudio Napoli, A. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.002 · Cited by 93 · see citing works
Self-citationTyml, K. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00080.x · Cited by 90 · see citing works
Reduced flow-mediated vasodilation as a marker for cardiovascular complications in lupus patients
Kiss, E. V., Soltész, P., Dér, H., Kocsis, Z., Tarr, T., Bhattoa, H. P., Shoenfeld, Y., & Szegedi, G. (2006) · Journal of Autoimmunity · doi:10.1016/j.jaut.2006.09.008 · Cited by 90 · see citing works
A Review of Recent Advancements in Sensor‐Integrated Medical Tools
Park, J., Seo, B., Jeong, Y., & Park, I. (2024) · Advanced Science · doi:10.1002/advs.202307427 · Cited by 89 · see citing works
Microvascular Regeneration in Established Pulmonary Hypertension by Angiogenic Gene Transfer
Zhao, Y. D., Courtman, D. W., Ng, D. S., Robb, M. J., Deng, Y., Trogadis, J. E., Han, R. N. N., & Stewart, D. J. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0115oc · Cited by 89 · see citing works
Anti-thrombogenic Surface Coatings for Extracorporeal Membrane Oxygenation: A Narrative Review
Zhang, M., Pauls, J. P., Bartnikowski, N., Haymet, A. B., Chan, C. H. H., Suen, J. Y., Schneider, B., Ki, K. K., Whittaker, A. K., Dargusch, M. S., et al. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00758 · Cited by 88 · see citing works
Kim, J. W., Suh, S. Y., Choi, C. U., Na, J. O., Kim, E. J., Rha, S., Park, C. G., Seo, H. S., & Oh, D. J. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2007.11.002 · Cited by 88 · see citing works
The cGMP system: components and function
Hofmann, F. B. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0386 · Cited by 86 · see citing works
Rocca, C., Pasqua, T., Boukhzar, L., Anouar, Y., & Angelone, T. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03195-1 · Cited by 85 · see citing works
Photobiomodulation and nitric oxide signaling
Kashiwagi, S., Morita, A., Yokomizo, S., Ogawa, E., Komai, E., Huang, P. L., Евгеньевич, Б. Д., & Atochin, D. N. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.11.005 · Cited by 83 · see citing works
Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production
Nocella, C., Carnevale, R., Bartimoccia, S., Novo, M., Cangemi, R., Pastori, D., Calvieri, C., Pignatelli, P., & Violi, F. (2017) · Thrombosis and Haemostasis · doi:10.1160/th16-11-0857 · Cited by 83 · see citing works
- Authors
- Loscalzo, J.
- Affiliations
- Boston University (US)
- Corresponding author
- Loscalzo, Joseph
- ORCID
- Loscalzo, Joseph
- Venue
- Circulation Research
- Published
- 2001-04-27
- Volume
- 88
- Issue
- 8
- Pages
- 756-762
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2113684546
- Cited by
- 612
- References
- 80
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 22 · 2023: 21 · 2022: 22 · 2021: 19 · 2020: 25 · 2019: 15 · 2018: 28 · 2017: 25 · 2016: 16 · 2015: 24 · 2014: 27 · 2013: 28 · 2012: 29
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL61795, HL 55993, HL58976, R01HL058976, P50HL055993)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- nitric oxide, platelet activation, arterial thrombosis, endothelial dysfunction, glutathione peroxidase 3, phosphatidylinositol 3-kinase, cyclooxygenase-1, guanylate cyclase, platelet aggregation, thromboprophylaxis
- MeSH terms
- Animals, Arteries, Blood Platelets, Endothelium, Vascular, Glutathione Peroxidase, Humans, Nitric Oxide, Thrombosis, Vasodilator Agents, Platelet Activation, Reactive Oxygen Species, Nitric Oxide Donors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review