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Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis

Tan, Josephine M.E., Cook, Emma C.L., van den Berg, Marlene, Scheij, Saskia, Zelcer, Noam, Loregger, Anke·2019·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2018.12.008
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Research works printed but not linked: 27

  1. Maxfield, 2010, Cholesterol, the central lipid of mammalian cells, Curr. Opin. Cell Biol., 22, 422, 10.1016/j.ceb.2010.05.004 · DOI · Paper page
  2. Brown, 1997, 89, 1
  3. Sharpe, 2014, The UPS and downs of cholesterol homeostasis, Trends Biochem. Sci., 39, 527, 10.1016/j.tibs.2014.08.008 · DOI · Paper page
  4. Gill, 2011, Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase, Cell Metabol., 13, 260, 10.1016/j.cmet.2011.01.015 · DOI · Paper page
  5. Stevenson, 2014, Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids, Biochem. J., 461, 10.1042/BJ20131404 · DOI
  6. Song, 2005, Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol, Cell Metabol., 1, 179, 10.1016/j.cmet.2005.01.001 · DOI
  7. Yang, 2006, Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands, J. Biol. Chem., 281, 27816, 10.1074/jbc.M603781200 · DOI
  8. DeBose-Boyd, 2008, Feedback regulation of cholesterol synthesis: sterol- accelerated ubiquitination and degradation of HMG CoA reductase, Cell Res., 18, 609, 10.1038/cr.2008.61 · DOI · Paper page
  9. Howe, 2015, The regulatory domain of squalene monooxygenase contains a re-entrant loop and senses cholesterol via a conformational change, J. Biol. Chem., 290, 27533, 10.1074/jbc.M115.675181 · DOI
  10. Stewart, 2016, E2 enzymes: more than just middle men, Cell Res., 26, 423, 10.1038/cr.2016.35 · DOI
  11. Loregger, 2017, Haploid mammalian genetic screen identifies UBXD8 as a key determinant of HMGCR degradation and cholesterol biosynthesis, Arterioscler. Thromb. Vasc. Biol., 37, 2064, 10.1161/ATVBAHA.117.310002 · DOI
  12. Jiang, 2014, Ubiquitin ligases in cholesterol metabolism, Diabetes Metab. J., 38, 171, 10.4093/dmj.2014.38.3.171 · DOI
  13. Volkmar, 2018, The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1, BioRxiv, 391789
  14. Miao, 2010, Tetra-glutamic acid residues adjacent to Lys248 in HMG-CoA reductase are critical for the ubiquitination mediated by gp78 and UBE2G2, Acta Biochim. Biophys. Sin., 42, 303, 10.1093/abbs/gmq022 · DOI
  15. Jo, 2011, Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8, Proc. Natl. Acad. Sci. Unit. States Am., 108, 20503, 10.1073/pnas.1112831108 · DOI
  16. Zelcer, 2014, The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway, Mol. Cell Biol., 34, 1262, 10.1128/MCB.01140-13 · DOI · Paper page
  17. Claessen, 2013, Protein quality control in the ER: balancing the ubiquitin chequebook, Trends Cell Biol., 22, 22, 10.1016/j.tcb.2011.09.010 · DOI
  18. van Wijk, 2010, The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins, Faseb. J., 24, 981, 10.1096/fj.09-136259 · DOI
  19. Lenk, 2002, A role for mammalian Ubc6 homologues in ER-associated protein degradation, J. Cell Sci., 115, 3007, 10.1242/jcs.115.14.3007 · DOI
  20. van de Weijer, 2017, Multiple E2 ubiquitin- conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation, J. Cell Sci., 130, 2883, 10.1242/jcs.206839 · DOI
  21. Lackner, 2015, A generic strategy for CRISPR-Cas9-mediated gene tagging, Nat. Commun., 6, 4, 10.1038/ncomms10237 · DOI
  22. Lam, 2014, The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation, Biochem. Biophys. Res. Commun., 451, 361, 10.1016/j.bbrc.2014.07.099 · DOI
  23. Zelcer, 2009, Ubiquitination of the LDL receptor, Science, 80, 100, 10.1126/science.1168974 · DOI · Paper page
  24. Sorrentino, 2012, Post-transcriptional regulation of lipoprotein receptors by the E3-ubiquitin ligase inducible degrader of the low-density lipoprotein receptor, Curr. Opin. Lipidol., 23, 213, 10.1097/MOL.0b013e3283532947 · DOI · Paper page
  25. Metzger, 2010, HECT and RING finger families of E3 ubiquitin ligases at a glance, J. Cell Sci., 125, 531, 10.1242/jcs.091777 · DOI
  26. Christianson, 2014, Cleaning up in the endoplasmic reticulum: ubiquitin in charge, Nat. Struct. Mol. Biol., 21, 325, 10.1038/nsmb.2793 · DOI
  27. Weber, 2016, Sequential poly- ubiquitylation by specialized conjugating enzymes expands the versatility of a quality control ubiquitin ligase, Mol. Cell., 63, 1, 10.1016/j.molcel.2016.07.020 · DOI

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Metadata

Authors
Tan, J. M. E., Cook, E. C. L., van den Berg, M., Scheij, S., Zelcer, N., & Loregger, A.
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2019-02
Volume
281
Pages
137-142
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2018.12.008
Cited by
46
References
4
Language
en
Licence
Funders
  • Dutch Heart Foundation (2013T111, 2016T015)
  • ERC Consolidator (617376)
  • European Research Council
  • Netherlands Organization for Scientific Research (91818643)
  • AMC

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