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Regulation of intestinal LDLR by the LXR-IDOL axis
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Absence of IDOL in tissues such as intestine and brain resulted in a marked increase in LDLR abundance.
“In contrast to the liver, absence of IDOL in other tissue, like the intestine and brain, resulted in a marked increase in LDLR abundance [75,76]”
From The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms (2025) · cites this paper as [76]
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Self-citationThe LXR–Idol Axis Differentially Regulates Plasma LDL Levels in Primates and Mice
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IDOL regulates systemic energy balance through control of neuronal VLDLR expression
Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0127-7 · Cited by 26
Adi, D., Lu, X.-Y., Fu, Z.-Y., Wei, J., Baituola, G., Meng, Y.-J., Zhou, Y.-X., Hu, A., Wang, J.-K., Lu, X.-F., et al. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.312589 · Cited by 24
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Sorted by citations
The low-density lipoprotein receptor: Emerging post-transcriptional regulatory mechanisms
Ndoj, K., Meurs, A., Papaioannou, D., Bjune, K., & Zelcer, N. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119082 · Cited by 17
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Metadata
- Authors
- van Loon, N. M., van Wouw, S. A. E., Ottenhoff, R., Nelson, J. K., Kingma, J., Scheij, S., Moeton, M., & Zelcer, N.
- Venue
- Atherosclerosis
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 315
- Pages
- 1-9
- ISSN
- 0021-9150
- Cited by
- 20
- References
- 7
- Language
- en
- Licence
- Funders
- European Research Council
- Hartstichting
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
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