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Cited by 16Blood properties and coagulationBlood Coagulation and Thrombosis MechanismsLipoproteins and Cardiovascular Health

Apolipoproteins and lipoprotein(a) as factors modulating fibrin clot properties in patients with severe aortic stenosis

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Siudut, Jakub, Natorska, Joanna, Wypasek, Ewa, Wiewiórka, Łukasz, Ostrowska-Kaim, Elżbieta, Wiśniowska-Śmiałek, Sylwia, Plens, Krzysztof, Musialek, Piotr +2 more·2022·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2022.01.011
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Abstract

Background and aims Large amounts of clot-bound lipoproteins were reported in proteomic analysis of plasma clot but their impact on fibrin clot properties is unknown. We investigated a contribution of lipid profile and apolipoproteins (apo) to the prothrombotic plasma fibrin clot phenotype in patients with aortic stenosis (AS).Methods In 138 patients with isolated severe AS, we determined serum apoA-I, A-II, B, C-II, C-III, E, oxidized low-density lipoprotein (OxLDL) and lipoprotein(a) concentrations. Plasma fibrin clot permeability (Ks), maximal absorbance (MaxAbs CLT2018 and MaxAbs Lys50), and fibrinolytic capacity were studied using 3 plasma-based lysis assays (CLT2018, CLT, and Lys50), and compared with well-matched patients without AS (control group).Results After adjustment for confounding factors, including statin use, only low-density lipoprotein cholesterol (LDL-C) and apoB levels were inversely associated with Ks. Triglycerides, apoC-II, and C-III were associated with MaxAbs CLT2018 and MaxAbs Lys50, explaining 56-64% of their variability. CLT2018 and CLT showed associations with total cholesterol, LDL-C, triglycerides, and OxLDL as well as with apoB, C-II, C-III, and E. ApoA-I, C-II, and C-III but not serum lipids were associated with Lys50. Only CLT2018 was associated with lipoprotein(a). ApoC-III, B, A-I, and E along with estimated glomerular filtration rate and OxLDL predicted hypofibrinolysis in multiple regression analysis. AS patients had higher lipoprotein(a) (+34.9%) and apoA-I (+25.9%) levels and less compact fibrin clots (-13.3% lower MaxAbs CLT2018, -53.2% lower MaxAbs Lys50, and +28.3% higher Ks) displaying higher susceptibility to lysis (-17.9% lower Lys50) in comparison with control group.Conclusions Apolipoproteins and OxLDL contribute to prothrombotic fibrin clot phenotype in severe AS. Moreover, apolipoproteins better than serum lipids predicted hypofibrinolysis, which provides additional argument for a role of elevated lipoproteins in the prothrombotic state.

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Authors
Siudut, J., Natorska, J., Wypasek, E., Wiewiórka, Ł., Ostrowska-Kaim, E., Wiśniowska-Śmiałek, S., Plens, K., Musialek, P., Legutko, J., & Undas, A.
Affiliations
  • Jagiellonian University (PL)
  • Andrzej Frycz Modrzewski Krakow University (PL)
  • John Paul II Hospital (PL)
  • Krakow Cardiovascular Research Institute (PL)
Corresponding author
Undas, Anetta
ORCID
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2022-03
Volume
344
Pages
49-56
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/j.atherosclerosis.2022.01.011
OpenAlex
W4207035431
Cited by
16
References
42
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 1
FWCI
2.26
Type
journal article
Language
en
Open access
Licence
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
  • Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
aortic stenosis, apolipoproteins, lipoprotein(a), fibrin clot properties, fibrin clot permeability, fibrinolysis, hypofibrinolysis, oxidized LDL, prothrombotic phenotype, apolipoprotein C-III, apolipoprotein B, apolipoprotein A-I, apolipoprotein E
MeSH terms
Aortic Valve Stenosis, Apolipoproteins, Apolipoproteins B, Fibrin, Fibrinolysis, Humans, Lipoprotein(a), Proteomics, Fibrin Clot Lysis Time

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