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Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages

O'Rourke, Sinead A., Neto, Nuno G.B., Devilly, Eimear, Shanley, Lianne C., Fitzgerald, Hannah K., Monaghan, Michael G., Dunne, Aisling·2022·Atherosclerosis
DOI 10.1016/j.atherosclerosis.2022.05.015
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  1. O'Neill, 2016, A guide to immunometabolism for immunologists, Nat. Rev. Immunol., 16, 553, 10.1038/nri.2016.70 · DOI · Paper page
  2. Galván-Peña, 2014, Metabolic reprograming in macrophage polarization, Front. Immunol., 5
  3. San-Millán, 2017, Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect, Carcinogenesis, 38, 119
  4. Palsson-McDermott, 2015, Pyruvate kinase M2 regulates hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages, Cell Metabol., 21, 347, 10.1016/j.cmet.2015.01.017 · DOI
  5. Altenberg, 2004, Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes, Genomics, 84, 1014, 10.1016/j.ygeno.2004.08.010 · DOI
  6. O'Rourke, 2019, The role of macrophages in the infarcted myocardium: orchestrators of ECM remodeling, Front. Cardiovasc. Med., 6, 10.3389/fcvm.2019.00101 · DOI
  7. Tomas, 2018, Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques, Eur. Heart J., 39, 2301, 10.1093/eurheartj/ehy124 · DOI
  8. Liu, 2016, High resolution FDG-microPET of carotid atherosclerosis: plaque components underlying enhanced FDG uptake, Int. J. Cardiovasc. Imag., 32, 145, 10.1007/s10554-015-0739-2 · DOI
  9. Folco, 2011, Hypoxia but not inflammation augments glucose uptake in human macrophages: implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography, J. Am. Coll. Cardiol., 58, 603, 10.1016/j.jacc.2011.03.044 · DOI
  10. Shirai, 2016, The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease, J. Exp. Med., 213, 337, 10.1084/jem.20150900 · DOI
  11. Mabile, 1997, Mitochondrial function is involved in LDL oxidation mediated by human cultured endothelial cells, Arterioscler. Thromb. Vasc. Biol., 17, 1575, 10.1161/01.ATV.17.8.1575 · DOI
  12. Perrotta, 2020, Partial inhibition of glycolysis reduces atherogenesis independent of intraplaque neovascularization in mice, Arterioscler. Thromb. Vasc. Biol., 40, 1168, 10.1161/ATVBAHA.119.313692 · DOI
  13. Poels, 2020, Inhibition of PFKFB3 hampers the progression of atherosclerosis and promotes plaque stability, Front. Cell Dev. Biol., 8, 10.3389/fcell.2020.581641 · DOI
  14. Cunningham, 2012, Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase, Clin. Immunol., 144, 228, 10.1016/j.clim.2012.06.007 · DOI
  15. Martinon, 2006, Gout-associated uric acid crystals activate the NALP3 inflammasome, Nature, 440, 237, 10.1038/nature04516 · DOI · Paper page
  16. Pazár, 2011, Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro, J. Immunol., 186, 2495, 10.4049/jimmunol.1001284 · DOI
  17. Grebe, 2013, Cholesterol crystals and inflammation, Curr. Rheumatol. Rep., 15, 10.1007/s11926-012-0313-z · DOI
  18. Corr, 2016, Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells, Atherosclerosis, 251, 197, 10.1016/j.atherosclerosis.2016.06.035 · DOI
  19. Duewell, 2010, NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Nature, 464, 1357, 10.1038/nature08938 · DOI · Paper page
  20. Mahon, 2020, Osteoarthritis-associated basic calcium phosphate crystals alter immune cell metabolism and promote M1 macrophage polarization, Osteoarthritis Cartilage, 28, 603, 10.1016/j.joca.2019.10.010 · DOI
  21. Hall, 2018, Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation, J. Clin. Invest., 128, 1752, 10.1172/JCI94584 · DOI
  22. Corr, 2017, Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells, Arthritis Res. Ther., 19, 23, 10.1186/s13075-017-1225-0 · DOI
  23. Murray, 2014, Macrophage activation and polarization: nomenclature and experimental guidelines, Immunity, 41, 14, 10.1016/j.immuni.2014.06.008 · DOI · Paper page
  24. Perottoni, 2021, Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip, Lab Chip, 21, 1395, 10.1039/D0LC01034K · DOI
  25. Diskin, 2018, Metabolic modulation in macrophage effector function, Front. Immunol., 9, 270, 10.3389/fimmu.2018.00270 · DOI
  26. Freemerman, 2014, Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype, J. Biol. Chem., 289, 7884, 10.1074/jbc.M113.522037 · DOI
  27. Tan, 2015, Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism, J. Immunol., 194, 6082, 10.4049/jimmunol.1402469 · DOI
  28. Kapetanovic, 2020, Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages, Immunol. Cell Biol., 98, 528, 10.1111/imcb.12363 · DOI
  29. Wang, 2014, Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-κb–mediated inflammation in macrophages, Circ. Res., 114, 421, 10.1161/CIRCRESAHA.114.302153 · DOI
  30. Hotamisligil, 2017, Foundations of immunometabolism and implications for metabolic health and disease, Immunity, 47, 406, 10.1016/j.immuni.2017.08.009 · DOI
  31. Koelwyn, 2018, Regulation of macrophage immunometabolism in atherosclerosis, Nat. Immunol., 19, 526, 10.1038/s41590-018-0113-3 · DOI
  32. Finucane, 2019, The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages, Sci. Rep., 9, 4034, 10.1038/s41598-019-40619-1 · DOI
  33. Holtmann, 1999, Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways, Mol. Cell Biol., 19, 6742, 10.1128/MCB.19.10.6742 · DOI
  34. van Tuijl, 2019, Immunometabolism orchestrates training of innate immunity in atherosclerosis, Cardiovasc. Res., 115, 1416, 10.1093/cvr/cvz107 · DOI
  35. Luo, 2011, Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1, Cell, 145, 732, 10.1016/j.cell.2011.03.054 · DOI · Paper page
  36. Mazurek, 2005, Pyruvate kinase type M2 and its role in tumor growth and spreading, Semin. Cancer Biol., 15, 300, 10.1016/j.semcancer.2005.04.009 · DOI · Paper page
  37. Moore, 2013, Macrophages in atherosclerosis: a dynamic balance, Nat. Rev. Immunol., 13, 709, 10.1038/nri3520 · DOI · Paper page
  38. Combadiere, 2008, Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice, Circulation, 117, 1649, 10.1161/CIRCULATIONAHA.107.745091 · DOI
  39. Segers, 2011, Atherosclerotic plaque stability is affected by the chemokine CXCL10 in both mice and humans, Int. J. Inflamm., 2011, 936109
  40. Moreau, 1999, Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages, Circulation, 99, 420, 10.1161/01.CIR.99.3.420 · DOI
  41. Abboud, 2018, Inhibition of glycolysis reduces disease severity in an autoimmune model of rheumatoid arthritis, Front. Immunol., 9, 1973, 10.3389/fimmu.2018.01973 · DOI
  42. Pålsson-McDermott, 2020, Targeting immunometabolism as an anti-inflammatory strategy, Cell Res., 30, 300, 10.1038/s41422-020-0291-z · DOI

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Metadata

Authors
O'Rourke, S. A., Neto, N. G. B., Devilly, E., Shanley, L. C., Fitzgerald, H. K., Monaghan, M. G., & Dunne, A.
ORCID
O'Rourke, Sinead A.
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2022-07
Volume
352
Pages
35-45
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2022.05.015
Cited by
62
References
5
Language
en
Licence
Funders
  • Engineering and Physical Sciences Research Council
  • Science Foundation Ireland (16/RI/3403, EP/S02347X/1)
  • Trinity College Dublin
  • European Regional Development Fund

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