Cited by 2,559Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismCerebrovascular and Carotid Artery Diseases

Macrophages in atherosclerosis: a dynamic balance

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Moore, Kathryn J., Sheedy, Frederick J., Fisher, Edward A.·2013·Nature reviews. Immunology

Abstract

Atherosclerosis is a chronic inflammatory disease that arises from an imbalance in lipid metabolism and a maladaptive immune response driven by the accumulation of cholesterol-laden macrophages in the artery wall. Through the analysis of the progression and regression of atherosclerosis in animal models, there is a growing understanding that the balance of macrophages in the plaque is dynamic and that both macrophage numbers and the inflammatory phenotype influence plaque fate. In this Review, we summarize recently identified pro- and anti-inflammatory pathways that link lipid and inflammation biology with the retention of macrophages in plaques, as well as factors that have the potential to promote their egress from these sites.

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Authors
Moore, K. J., Sheedy, F. J., & Fisher, E. A.
Affiliations
  • New York University (US)
  • NYU Langone Health (US)
Corresponding author
  • Moore, Kathryn J.
  • Fisher, Edward A.
Venue
Nature reviews. Immunology
Published
2013-09-02
Volume
13
Issue
10
Pages
709-721
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2079724669
Cited by
2,559
References
117
Citations by year
2026: 143 · 2025: 210 · 2024: 238 · 2023: 247 · 2022: 241 · 2021: 231 · 2020: 245 · 2019: 195 · 2018: 215 · 2017: 177 · 2016: 183 · 2015: 132 · 2014: 92 · 2013: 6
FWCI
11.66
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG020255)
  • National Heart, Lung, and Blood Institute (R01HL084312, R01HL117334, P01HL098055, R01 R01HL117334, R01HL108182)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords
macrophages, atherosclerosis, atherosclerotic plaque, plaque regression, macrophage dynamics, lipid metabolism, inflammation, anti-inflammatory pathways, pro-inflammatory pathways, plaque stability
MeSH terms
Animals, Arteries, Cell Count, Cell Movement, Cholesterol, Humans, Inflammation, Macrophages, Monocytes, Biomarkers, Atherosclerosis, Lipid Metabolism, Mice, Plaque, Atherosclerotic

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