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Cited by 73Gastrointestinal motility and disordersNeuropeptides and Animal PhysiologyCongenital gastrointestinal and neural anomalies

Autonomic nervous system and secretion across the intestinal mucosal surface

Open access
Xue, Jianjing, Askwith, Candice, Javed, Najma H., Cooke, Helen J.·2007·Autonomic Neuroscience
DOI 10.1016/j.autneu.2007.02.001PMC PMC1936976
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Abstract

Chloride secretion is important because it is the driving force for fluid movement into the intestinal lumen. The flow of accumulated fluid flushes out invading micro-organisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous system. Mechanosensitive enterochromaffin cells that release 5-hydroxytryptamine (5-HT) and activate intrinsic afferent neurons in the submucosal plexus and initiate chloride secretion. Mechanical stimulation by distention may also trigger reflexes by a direct action on intrinsic afferent neurons. Dysregulation of 5-HT release or altered activity of intrinsic afferents is likely to occur in states of inflammation and other disorders.

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  • Activation of intrinsic afferents results in neural reflexes that enhance the release of chloride ions and water into the intestinal lumen.

    “Activation of intrinsic afferents results in neural reflexes that enhance the release of chloride ions and water into the intestinal lumen.65”

    From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [65]

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Research works printed but not linked: 3

  1. [13]Cooke HJ, Christofi FL. Enteric neural regulation of mucosal secretion. In: Johnson LR, editor. Physiology of the Gastrointestinal Tract. Academic press; 2006. pp. 737–762. [Google Scholar]
  2. [55]Wang GD, Wang XY, Liu S, Fei GJ, Hu HZ, Xia Y, Wood JD. Extrinsic primary afferent neurons stimulate enteric mast cells to release histamine as a paracrine modulator in the enteric nervous system in the guinea-pig intestine. Gastroenterology. 2006;130:A-30. [Google Scholar]
  3. [58]Wood JD. Integrative functions of enteric nervous system. In: Johnson LR, editor. Physiology of the Gastrointestinal Tract. Academic press; 2006A. pp. 665–683. [Google Scholar]

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Authors
Xue, J., Askwith, C., Javed, N. H., & Cooke, H. J.
Affiliations
  • The Ohio State University (US)
  • Ball State University (US)
Corresponding author
Cooke, Helen J.
Venue
Autonomic Neuroscience
Publisher
Elsevier BV
Published
2007-04
Volume
133
Issue
1
Pages
55-63
ISSN
1566-0702 (ISSN-L)
DOI
10.1016/j.autneu.2007.02.001
PMC
PMC1936976
OpenAlex
W1981815916
Cited by
73
References
63
Citations by year
2026: 4 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 5 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 6 · 2012: 7
FWCI
0.80
Type
journal article
Language
en
Open access
Licence
Locations
  • Autonomic Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK037240)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords
chloride secretion, intestinal secretion, enteric nervous system, submucosal plexus, enterochromaffin cells, serotonin, mechanosensitive neurons, intestinal distension, intestinal inflammation, intestinal mucosa
MeSH terms
Animals, Autonomic Nervous System, Chlorides, Humans, Intestinal Mucosa, Neurons, Serotonin

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