Sensory mechanisms: transmitters, modulators and reflexes
Abstract
The enteric nervous system in combination with inputs from parasympathetic and sympathetic nerves regulate the contractile, secretory and vasomotor activity of the gastrointestinal track via neural reflexes. Sensory elements which may be present in specialized neurones, enteroendocrine cells or mast cells detect changes in force, chemical composition or even foreign antigens. Sensory elements signal the enteric nervous system to correct these changes by altering contractile activity, secretion and blood flow. Advances have been made in understanding the sensory mechanisms that are involved in 5‐hydroxytryptamine (5‐HT) release from enterochromaffin cells (EC) or a model for EC cells. These advances relate to roles for ATP and its metabolites ADP and adenosine in mechanotransduction and a role for a sodium glucose cotransporter, a SGLT‐like protein, in chemotransduction.
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Nerve terminals of vagal afferents are located in close proximity to enterochromaffin cells, and these terminals express the serotonin-specific receptor 5-HT3R.
“Nerve terminals of vagal afferents are located in close proximity to enterochromaffin cells, and these terminals express the serotonin-specific receptor 5-HT3R.67”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [67]
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- Authors
- Raybould, H. E., Cooke, H. J., & Christofi, F. L.
- Affiliations
- University of California, Davis (US)
- The Ohio State University (US)
- Corresponding author
- Raybould, H. E.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 16
- Issue
- s1
- Pages
- 60-63
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2012545056
- Cited by
- 90
- References
- 15
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK57016, DK44179, R01DK037240, DK-58588, DK 41004, R01DK057016, DK DK37240)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- enteric nervous system, neural reflexes, enteroendocrine cells, mast cells, 5-hydroxytryptamine release, enterochromaffin cells, mechanotransduction, chemotransduction, sodium-glucose cotransporter, gastrointestinal motility, gastrointestinal secretion, vasomotor activity
- MeSH terms
- Animals, Digestive System, Enterochromaffin Cells, Gastrointestinal Motility, Humans, Sensory Receptor Cells, Reflex, Enteric Nervous System, Mechanotransduction, Cellular
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