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Autonomic predictors of recovery following surgery: A comparative study
Open accessAbstract
Although heart rate and temperature are continuously monitored in patients during recovery following surgery, measures that extract direct manifestations of neural regulation of autonomic circuits from the beat-to-beat heart rate may be more sensitive to outcome. We explore the relationship between features of autonomic regulation and survival in the prairie vole, a small mammal, with features of vagal regulation of the heart similar to humans. Cardiac vagal regulation is manifested in the beat-to-beat heart rate variability (HRV) pattern and can be quantified by extracting measures of the amplitude of periodic oscillations associated with spontaneous breathing. Thus, monitoring beat-to-beat heart rate patterns post-surgery in the prairie vole may provide an opportunity to dynamically assess autonomic adjustments during recovery. Surgeries to implant telemetry devices to monitor body temperature and continuous ECG in prairie voles are routinely performed in our laboratory. Ten of these implanted prairie voles died within 48 h post-surgery. To compare the post-surgery autonomic trajectories with typical surviving prairie voles, the post-surgery data from 17 surviving prairie voles were randomly selected. The data are reported hourly for 27 prairie voles between 6 and 14 h (1h before the demise of the first subject) post-surgery. Receiver operator curves were calculated hourly for each variable to evaluate sensitivity in discriminating survival. The data illustrate that measures of HRV are the most sensitive indicators. These findings provide a foundation for investigating further neural mechanisms of cardiovascular function.
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Several features in the resting heart rate spectra (very low frequency, low frequency, and high frequency) are correlated with mortality.
“Several features in the resting heart rate spectra (very low frequency, low frequency, and high frequency) are correlated with mortality (Williamson et al., 2010).”
From Maladaptive autonomic regulation in PTSD accelerates physiological aging (2015) · cites this paper as Williamson et al., 2010
The Methods describe two measured spectral components, low frequency (LF) and high-frequency respiratory sinus arrhythmia (RSA). The Results and Discussion link both to survival or demise in prairie voles after surgery. The paper does not report a very-low-frequency component or establish the claimed relationship for resting heart-rate spectra. (LLM, conf=0.88)
Experimental — accuracy not yet measuredVE precedes death following surgery in prairie voles.
“preceding death following surgery in prairie voles [66]”
From The vagal paradox: A polyvagal solution (2023) · cites this paper as [66]
The Methods (section 2.6) identify the measured cardiac variables as heart period, RSA and LF heart-rate variability, and the Discussion (section 5) says RSA and LF predicted demise after surgery. Our copy does not identify or report VE preceding death; searches for VE and possible expansions did not establish what VE refers to here. Page numbers were unavailable in the indexed passages. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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1 of the 28 references couldn’t be matched to a known paper.
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Maladaptive autonomic regulation in PTSD accelerates physiological aging
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The Neuroendocrine and Cardiovascular Responses to a Pup in Male Prairie Voles (M. ochrogaster)
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Metadata
- Authors
- Williamson, J. B., Lewis, G., Grippo, A. J., Lamb, D., Harden, E., Handleman, M., Lebow, J., Carter, C. S., & Porges, S. W.
- Affiliations
- University of Florida (US)
- Northern Illinois University (US)
- University of Illinois Chicago (US)
- Illinois Institute of Technology (US)
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 156
- Issue
- 1-2
- Pages
- 60-66
- ISSN
- 1566-0702 (ISSN-L)
- PMC
- PMC4801019
- OpenAlex
- W1996927498
- Cited by
- 14
- References
- 28
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2019: 2 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autonomic Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5f32ag027648-02)
- National Institute on Aging (F32 AG027648-01A1, L30 AG029070, F32 AG027648, R01AG017934)
- National Institute of Mental Health (R21MH077581, F32MH073233, R01MH072935, R21 MH0674467)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- postoperative recovery, autonomic regulation, heart rate variability, Microtus ochrogaster, survival prediction, telemetry monitoring, receiver operating characteristic
- MeSH terms
- Animals, Autonomic Nervous System, Arvicolinae, Female, Heart Rate, Postoperative Complications, Predictive Value of Tests, Minimally Invasive Surgical Procedures, Recovery of Function
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