The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding
Abstract
There is growing interest in the role of autoimmunity in postural orthostatic tachycardia syndrome (POTS). In recent years, investigators have described an increased rate of co-morbid autoimmune disease, and the presence of several neural receptor autoantibodies and non-specific autoimmune markers in POTS. Case reports on the efficacy of immunotherapy in highly selected POTS patients continue to appear in the literature, while no prospective clinical trials have occurred to date. This article summarizes the current state of knowledge on the role of autoimmunity in POTS, the clinical implications of these findings, and prospects for future research.
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In the citing paper
“Antibodies against GPCRs have been linked to a number of conditions, including POTS (Luft, 2013”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Vernino and Stiles, 2018
In the citing paper
“POTS patients (Vernino and Stiles, 2018) and their close relatives (Boris et al., 2020; Shaw et al., 2019) have a higher than expected prevalence of autoimmune disorders including celiac disease (Penny et al., 2016), Hashimoto’s thyroiditis (Blitshteyn, 2015), Sjögren’s syndrome (Goodman et al., 2017), and systemic lupus erythematosus (SLE) (Tang et al., 2004).”
From Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 (2021) · cites this paper as Vernino and Stiles, 2018
In the citing paper
“Serum immunoglobulins isolated from POTS patients have been reported to act as partial agonists to both α- and β-adrenergic receptors in vitro (Fedorowski et al., 2017; Li et al., 2014), a finding independently confirmed by several other groups (Vernino and Stiles, 2018) and expanded to include a wider range of G-protein coupled receptors (GPCRs) as targets (Kharraziha et al., 2020).”
From Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 (2021) · cites this paper as Vernino and Stiles, 2018
Citations
Cites
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Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516
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Cited by
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Items 101–106 of 106
Medic Spahic, J., Ricci, F., Aung, N., Hallengren, E., Axelsson, J., Hamrefors, V., Melander, O., Sutton, R., & Fedorowski, A. (2020) · Figshare · doi:10.6084/m9.figshare.12177873
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Postural Orthostatic Tachycardia Syndrome and Dermatomyositis.
Jun, S., Xie, L., Gomes, L. L. A., Saksena, S., Wei, E., Stone, C. J., Faden, D. F., Yang, X.-W., Eldaboush, A., & Werth, V. (2026) · JAMA dermatology · doi:10.1001/jamadermatol.2026.2132
POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME (POTS) IN PRIMARY CARE: DIAGNOSIS AND MANAGEMENT
Sumlet, P., Małajewicz, I., Spychalska, W., Kurasińska, W., Kolm, M., Chmielewska, Z., Drzewińska, K., Suszczyńska, W., Gofron, M., & Duliński, M. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.3(51).2026.6253
Huang, I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-23516-0.00127-6
Marchetta, M., Hogwood, A. C., Golino, M., Abbate, G., THOMAS, G. K., Markley, R., Stavrakis, S., Canada, J. M., & Abbate, A. (2026) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2026.10.007
Metadata
- Authors
- Vernino, S., & Stiles, L. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Stiles, Lauren E.
- Venue
- Autonomic Neuroscience
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 215
- Pages
- 78-82
- ISSN
- 1566-0702 (ISSN-L)
- OpenAlex
- W2801111658
- Cited by
- 107
- References
- 58
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 24 · 2021: 22 · 2020: 18 · 2019: 8 · 2018: 3
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autonomic Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- postural orthostatic tachycardia syndrome, autoimmunity, autoimmune disease comorbidity, autoimmune markers, immunotherapy, autonomic dysfunction
- MeSH terms
- Autoimmune Diseases, Humans, Immunotherapy, Comorbidity, Postural Orthostatic Tachycardia Syndrome
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