The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura)
Open accessAbstract
Immunoglobulin A vasculitis (IgAV), also referred to as Henoch-Schönlein purpura, is the most common form of childhood vasculitis. The pathogenesis of IgAV is still largely unknown. The disease is characterized by IgA1-immune deposits, complement factors and neutrophil infiltration, which is accompanied with vascular inflammation. Incidence of IgAV is twice as high during fall and winter, suggesting an environmental trigger associated to climate. Symptoms can resolve without intervention, but some patients develop glomerulonephritis with features similar to IgA nephropathy that include hematuria, proteinuria and IgA deposition in the glomerulus. Ultimately, this can lead to end-stage renal disease. In IgA nephropathy immune complexes containing galactose-deficient (Gd-)IgA1 are found and thought to play a role in pathogenesis. Although Gd-IgA1 complexes are also present in patients with IgAV with nephritis, their role in IgAV is disputed. Alternatively, it has been proposed that in IgAV IgA1 antibodies are generated against endothelial cells. We anticipate that such IgA complexes can activate neutrophils via the IgA Fc receptor FcαRI (CD89), thereby inducing neutrophil migration and activation, which ultimately causes tissue damage in IgAV. In this Review, we discuss the putative role of IgA, IgA receptors, neutrophils and other factors such as infections, genetics and the complement system in the pathogenesis of IgA vasculitis.
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Cites
2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides
Jennette, J. C., Falk, R. J., Bacon, P. A., Basu, N., Cid, M. C., Ferrario, F., Flores‐Suarez, L. F., Gross, W. L., Guillevin, L., Hagen, E. C., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37715 · Cited by 6,631
Wyatt, R. J., & Julian, B. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1206793 · Cited by 1,222
Gardner-Medwin, J. M., Dolezalova, P., Cummins, C., & Southwood, T. R. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11279-7 · Cited by 787
The function of immunoglobulin A in immunity
Woof, J. M., & Kerr, M. A. (2006) · The Journal of Pathology · doi:10.1002/path.1877 · Cited by 716
Tomana, M., Novak, J., Julian, B. A., Matousovic, K., Konecny, K., & Mestecky, J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5535 · Cited by 498
The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action
Simmonds, M., & Gough, S. (2007) · Current Genomics · doi:10.2174/138920207783591690 · Cited by 472
Roos, A., Rastaldi, M. P., Calvaresi, N., Oortwijn, B. D., Schlagwein, N., van Gijlswijk-Janssen, D. J., Stahl, G. L., Matsushita, M., Fujita, T., van Kooten, C., et al. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005090923 · Cited by 450
Human IgA Activates the Complement System Via the Mannan-Binding Lectin Pathway
Roos, A., Bouwman, L. H., van Gijlswijk-Janssen, D. J., Faber-Krol, M. C., Stahl, G. L., & Daha, M. R. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.5.2861 · Cited by 431
Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels
Moldoveanu, Z., Wyatt, R. J., Lee, J. Y., Tomana, M., Julian, B. A., Mestecky, J., Huang, W.-Q., Anreddy, S. R., Hall, S., Hastings, M. C., et al. (2007) · Kidney International · doi:10.1038/sj.ki.5002185 · Cited by 422
Identification of FcαRI as an Inhibitory Receptor that Controls Inflammation
Pasquier, B., Launay, P., Kanamaru, Y., Moura, I. C., Pfirsch, S., Ruffié, C., Hénin, D., Benhamou, M., Pretolani, M., Blank, U., et al. (2005) · Immunity · doi:10.1016/j.immuni.2004.11.017 · Cited by 346
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Cited by
Connelly‐Smith, L., Alquist, C. R., Aqui, N. A., Hofmann, J. C., Klingel, R., Onwuemene, O. A., Patriquin, C. J., Pham, H. P., Sanchez, A. P., Schneiderman, J., et al. (2023) · Journal of Clinical Apheresis · doi:10.1002/jca.22043 · Cited by 684
Metadata
- Authors
- Heineke, M. H., Ballering, A. V., Jamin, A., Ben Mkaddem, S., Monteiro, R. C., & Van Egmond, M.
- Venue
- Autoimmunity Reviews
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 16
- Issue
- 12
- Pages
- 1246-1253
- ISSN
- 1568-9972 (ISSN-L)
- OpenAlex
- W2763037910
- Cited by
- 329
- References
- 61
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Heineke, M. H., Ballering, A. V., Jamin, A., Ben Mkaddem, S., Monteiro, R. C., & Van Egmond, M. (2017). New insights in the pathogenesis of immunoglobulin A vasculitis (Henoch-Schönlein purpura). Autoimmunity Reviews. https://doi.org/10.1016/j.autrev.2017.10.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
