The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Human IgA Activates the Complement System Via the Mannan-Binding Lectin Pathway
Open accessAbstract
The recently identified lectin pathway of the complement system, initiated by binding of mannan-binding lectin (MBL) to its ligands, is a key component of innate immunity. MBL-deficient individuals show an increased susceptibility for infections, especially of the mucosal system. We examined whether IgA, an important mediator of mucosal immunity, activates the complement system via the lectin pathway. Our results indicate a dose-dependent binding of MBL to polymeric, but not monomeric IgA coated in microtiter plates. This interaction involves the carbohydrate recognition domain of MBL, because it was calcium dependent and inhibited by mannose and by mAb against this domain of MBL. Binding of MBL to IgA induces complement activation, as demonstrated by a dose-dependent deposition of C4 and C3 upon addition of a complement source. The MBL concentrations required for IgA-induced C4 and C3 activation are well below the normal MBL plasma concentrations. In line with these experiments, serum from individuals having mutations in the MBL gene showed significantly less activation of C4 by IgA and mannan than serum from wild-type individuals. We conclude that MBL binding to IgA results in complement activation, which is proposed to lead to a synergistic action of MBL and IgA in antimicrobial defense. Furthermore, our results may explain glomerular complement deposition in IgA nephropathy.
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Cites
Mechanisms of phagocytosis in macrophages
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A second serine protease associated with mannan-binding lectin that activates complement
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Mannose-binding lectin: the pluripotent molecule of the innate immune system
Turner, M. (1996) · Immunology Today · doi:10.1016/0167-5699(96)10062-1 · Cited by 735
Neth, O., Jack, D. L., Dodds, A. W., Holzel, H., Klein, N. J., & Turner, M. W. (2000) · Infection and Immunity · doi:10.1128/iai.68.2.688-693.2000 · Cited by 561
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Mannose binding protein gene mutations associated with unusual and severe infections in adults
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Complement Activation after Oxidative Stress
Collard, C. D., Väkevä, A., Morrissey, M. A., Agah, A., Rollins, S. A., Reenstra, W. R., Buras, J. A., Meri, S., & Stahl, G. L. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65026-2 · Cited by 336
Self-citationProteolytic Activities of Two Types of Mannose-Binding Lectin-Associated Serine Protease
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Cited by
The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins
Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141702 · Cited by 1,307
Rodrigues, J. C., Haas, M., & Reich, H. N. (2017) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.07420716 · Cited by 555
The role of complement in biomaterial-induced inflammation
Nilsson, B., Ekdahl, K. N., Mollnes, T. E., & Lambris, J. D. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.06.020 · Cited by 431
Mannose‐binding lectin and innate immunity
Eddie Ip, W. K., Takahashi, K., Alan Ezekowitz, R., & Stuart, L. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00789.x · Cited by 422
Structure and function relationships in IgA
Woof, J. M., & Russell, M. W. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.39 · Cited by 367
Metadata
- Authors
- Roos, A., Bouwman, L. H., van Gijlswijk-Janssen, D. J., Faber-Krol, M. C., Stahl, G. L., & Daha, M. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-09-01
- Volume
- 167
- Issue
- 5
- Pages
- 2861-2868
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2140590997
- Cited by
- 431
- References
- 22
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Roos, A., Bouwman, L. H., van Gijlswijk-Janssen, D. J., Faber-Krol, M. C., Stahl, G. L., & Daha, M. R. (2001). Human IgA Activates the Complement System Via the Mannan-Binding Lectin Pathway. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.5.2861
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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