Cited by 111Systemic Lupus Erythematosus ResearchSkin and Cellular Biology ResearchSystemic Sclerosis and Related Diseases

Vimentin as antigenic target in autoimmunity: A comprehensive review

Musaelyan, Aram, Lapin, Sergey, Nazarov, Vladimir, Tkachenko, Olga, Gilburd, Boris, Mazing, Alexandra, Mikhailova, Lilia, Shoenfeld, Yehuda·2018·Autoimmunity Reviews

Abstract

Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.

Integrity signals

Registry

Crossref · 10.1016/j.autrev.2018.04.004

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Musaelyan, A., Lapin, S., Nazarov, V., Tkachenko, O., Gilburd, B., Mazing, A., Mikhailova, L., & Shoenfeld, Y.
Affiliations
  • First Pavlov State Medical University of St. Petersburg (RU)
  • Tel Aviv University (IL)
  • St Petersburg University (RU)
Corresponding author
Lapin, Sergey
Venue
Autoimmunity Reviews
Publisher
Elsevier BV
Published
2018-09
Volume
17
Issue
9
Pages
926-934
ISSN
1568-9972 (ISSN-L)
OpenAlex
W2883842005
Cited by
111
References
110
Citations by year
2026: 5 · 2025: 9 · 2024: 16 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 26 · 2019: 12 · 2018: 1
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Locations
  • Autoimmunity Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Government of the Russian Federation (14.W03.31.0009)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
Keywords
vimentin, autoimmunity, intermediate filaments, citrullinated vimentin, post-translational modification, rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, idiopathic pulmonary fibrosis, HLA-DRB1*0301, cardiolipin, thrombus formation, autoantibodies, antigenic determinants, tubulointerstitial inflammation, glomerulonephritis
MeSH terms
Arthritis, Rheumatoid, Humans, Lupus Erythematosus, Systemic, Protein Processing, Post-Translational, Vimentin, Autoimmunity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review