The heterogeneity of picture-supported narratives in Alzheimer’s disease
Abstract
This study describes discourse patterns produced by 46 Alzheimer disease (AD) patients and 53 normal elderly subjects in two picture-supported narratives. Nine measures derived from a cognitive model of discourse processing were obtained and submitted to cluster analysis. Results indicate that discourse patterns elicited from both stimuli were heterogeneous. Further, they fail to clearly differentiate between normal aging and AD in half of the AD patients. Discourse patterns are examined in light of various sources of heterogeneity including severity of cognitive impairment, subject characteristics, and task demands. The usefulness of discourse as a diagnostic and therapeutic tool is discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One reviewed paper describes discourse patterns.
“Outside of those, seven papers are concerned with three or four disease stages [12, 50, 62–66], two explore longitudinal cognitive changes (although still through binary classification) [67, 68], and one describes discourse patterns [69].”
From Artificial Intelligence, Speech, and Language Processing Approaches to Monitoring Alzheimer’s Disease: A Systematic Review (2020) · cites this paper as [69]
Only one reviewed article had a different aim than classification: Duong et al. attempted to describe AD and healthy control discourse patterns through cluster analysis.
“There is only one article with a different aim than classification. This is the study by Duong et al. [69], who attempt to describe AD and HC discourse patterns through cluster analysis.”
From Artificial Intelligence, Speech, and Language Processing Approaches to Monitoring Alzheimer’s Disease: A Systematic Review (2020) · cites this paper as [69]
Most reviewed papers employ supervised learning, except one study that uses cluster analysis.
“Most reviewed papers employ supervised learning, except for a study that uses cluster analysis to investigate distinctive discourse patterns among participants [69].”
From Artificial Intelligence, Speech, and Language Processing Approaches to Monitoring Alzheimer’s Disease: A Systematic Review (2020) · cites this paper as [69]
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Toward a model of text comprehension and production.
Kintsch, W., & van Dijk, T. A. (1978) · Psychological Review · doi:10.1037/0033-295x.85.5.363 · Cited by 5,298 · see citing works
The Global Deterioration Scale for assessment of primary degenerative dementia
Reisberg, ., Ferris, S. H., de Leon, M. J., & Crook, T. H. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1136 · Cited by 4,982 · see citing works
The role of knowledge in discourse comprehension: A construction-integration model.
Kintsch, W. (1988) · Psychological Review · doi:10.1037/0033-295x.95.2.163 · Cited by 4,388 · see citing works
Aldenderfer, M. S. (1984) · Cited by 2,502 · see citing works
The Bells Test: A quantitative and qualitative test for visual neglect.
Gauthier, L., Dehaut, F., & Joanette, Y. (1989) · The International journal of clinical neuropsychology · Cited by 1,061 · see citing works
Benton, A. L. (1978) · Archives of Neurology · doi:10.1001/archneur.1978.00500300038006 · Cited by 1,014 · see citing works
SEMANTIC MEMORY LOSS IN DEMENTIA OF ALZHEIMER'S TYPE
Chertkow, H. M., & Bub, D. N. (1990) · Brain · doi:10.1093/brain/113.2.397 · Cited by 571 · see citing works
A study of language functioning in Alzheimer patients
Appell, J., KERTESZ, A. E., & Fisman, M. (1982) · Brain and Language · doi:10.1016/0093-934x(82)90006-2 · Cited by 524 · see citing works
Communication and Cognition in Normal Aging and Dementia
Bayles, K. A., Kaszniak, A. W., & Tomoeda, C. K. (1987) · Medical Entomology and Zoology · Cited by 398 · see citing works
Patterns of discourse production among neurological patients with fluent language disorders
Glosser, G., & Deser, T. (1991) · Brain and Language · doi:10.1016/0093-934x(91)90117-j · Cited by 313 · see citing works
Empty Speech in Alzheimer's Disease and Fluent Aphasia
Nicholas, M. L., Obler, L. K., Albert, M. L., & Helm‐Estabrooks, N. (1985) · Journal of Speech Language and Hearing Research · doi:10.1044/jshr.2803.405 · Cited by 304 · see citing works
Stemmer, B. (1998) · Elsevier eBooks · doi:10.1016/b978-0-12-666055-5.x5000-x · Cited by 249 · see citing works
Towards a behavioral typology of Alzheimer's patients
Martin, A. D., Brouwers, P. Y., Lalonde, F. M., Cox, C., Foster, N. L., & Chase, T. N. (1986) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638608405178 · Cited by 236 · see citing works
Almor, A., Kempler, D., MacDonald, M. C., Andersen, E. S., & TYLER, L. K. (1999) · Brain and Language · doi:10.1006/brln.1999.2055 · Cited by 220 · see citing works
Comparative Study of Oral and Written Picture Description in Patients with Alzheimer's Disease
Croisile, B., Ska, B., Brabant, M.-J., Duchêne, A., Lepage, Y., Aimard, G., & Trillet, M. (1996) · Brain and Language · doi:10.1006/brln.1996.0033 · Cited by 216 · see citing works
Self-citationComment on se rappelle et on résume des histoires
Kintsch, W., & van Dijk, T. A. (1975) · Langages · doi:10.3406/lgge.1975.2300 · Cited by 192 · see citing works
Naming ability across the adult life span
Au, R., Joung, P., Nicholas, M. L., Obler, L. K., Kass, R., & Albert, M. L. (1995) · Aging Neuropsychology and Cognition · doi:10.1080/13825589508256605 · Cited by 148 · see citing works
Glosser, G., & Deser, T. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.4.p266 · Cited by 146 · see citing works
Production of complex syntax in normal ageing and alzheimer's disease
Bates, E. A., Harris, C. R., Marchman, V. A., Wulfeck, B. B., & Kritchevsky, M. (1995) · Language and Cognitive Processes · doi:10.1080/01690969508407113 · Cited by 142 · see citing works
Discourse Production and Normal Aging: Performance on Oral Picture Description Tasks
Cooper, P. V. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.5.p210 · Cited by 142 · see citing works
AGING, MILD COGNITIVE IMPAIRMENT, AND ALZHEIMER'S DISEASE
Petersen, R. C. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70226-7 · Cited by 141 · see citing works
Giles, E., Patterson, K., & Hodges, J. R. (1996) · Aphasiology · doi:10.1080/02687039608248419 · Cited by 139 · see citing works
Adult spoken discourse: the influences of age and education
Mackenzie, C. (2000) · International Journal of Language & Communication Disorders · doi:10.1080/136828200247188 · Cited by 132 · see citing works
Discourse ability and brain damage : theoretical and empirical perspectives
Joanette, Y., & Brownell, H. (1990) · Springer eBooks · Cited by 115 · see citing works
Adults' Reading Comprehension: Effects of Syntactic Complexity and Working Memory
Norman, S., Kemper, S., & Kynette, D. (1992) · Journal of Gerontology · doi:10.1093/geronj/47.4.p258 · Cited by 110 · see citing works
The Cognitive Representation and Processing of Discourse: Function and Dysfunction
Frederiksen, C. H., Bracewell, R. J., Breuleux, A., & Renaud, A. (1990) · Springer series in neuropsychology · doi:10.1007/978-1-4612-3262-9_4 · Cited by 104 · see citing works
Bullock, R. A. (2005) · Psychiatry · doi:10.1383/psyt.4.1.64.58310 · Cited by 101 · see citing works
Heterogeneity of Alzheimer’s Disease
(1992) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-46776-9 · Cited by 93 · see citing works
Gender differences in language of AD patients
Ripich, D. N., Petrill, S. A., Whitehouse, P. J., & Ziol, E. W. (1995) · Neurology · doi:10.1212/wnl.45.2.299 · Cited by 93 · see citing works
Ehrlich, J. S., Obler, L. K., & Clark, L. W. (1997) · Journal of Communication Disorders · doi:10.1016/0021-9924(95)00053-4 · Cited by 92 · see citing works
Spontaneous Speech of Patients With Dementia of the Alzheimer Type and Mild Cognitive Impairment
Bschor, T., Reischies, F. M., & Kühl, K.-P. (2001) · International Psychogeriatrics · doi:10.1017/s1041610201007682 · Cited by 92 · see citing works
Is There a Decline in Picture Naming With Advancing Age?
Goulet, P., Ska, B., & Kahn, H. J. (1994) · Journal of Speech Language and Hearing Research · doi:10.1044/jshr.3703.629 · Cited by 90 · see citing works
Self-citationEffects of age and education on the lexico-semantic content of connected speech in adults
Dorze, G. L., & BÉDard, C. (1998) · Journal of Communication Disorders · doi:10.1016/s0021-9924(97)00051-8 · Cited by 84 · see citing works
Discourse Analysis and Applications
Bloom, R. L., Obler, L. K., Santi, S. D., et al. (2013) · Psychology Press eBooks · doi:10.4324/9780203773352 · Cited by 81 · see citing works
Longitudinal effects of Alzheimer disease on discourse production.
Tomoeda, C. K., & Bayles, K. A. (1993) · PubMed · Cited by 75 · see citing works
Tomoeda, C. K., Bayles, K. A., Trosset, M. W., Azuma, T., & McGeagh, A. (1996) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199601040-00006 · Cited by 72 · see citing works
Heterogeneity in the cognitive profile of normal elderly
Valdois, S., Joanette, Y., Poissant, A., et al. (1990) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639008401003 · Cited by 60 · see citing works
Decline of Language Among Women and Men With Alzheimer's Disease
Hebert, L. E., Wilson, R. S., Gilley, D. W., Beckett, L. A., Scherr, P. A., Bennett, D. A., & Evans, D. A. (2000) · The Journals of Gerontology Series B · doi:10.1093/geronb/55.6.p354 · Cited by 55 · see citing works
Language and Communication Disorders in Dementia of the Alzheimer Type
Caramelli, P., Mansur, L. L., & Nitríni, R. (1998) · Elsevier eBooks · doi:10.1016/b978-012666055-5/50036-8 · Cited by 52 · see citing works
Language dysfunction in early‐ and late‐onset possible Alzheimer's disease
Seines, O. A., Carson, K. A., Rovner, B. W., & Gordon, B. (1988) · Neurology · doi:10.1212/wnl.38.7.1053 · Cited by 51 · see citing works
Age at onset and language disturbances in Alzheimer’s disease
Imamura, T., Takatsuki, Y., Fujimori, M., Hirono, N., Ikejiri, Y., Shimomura, T., Hashimoto, M., Yamashita, H., & Mori, E. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(98)00010-4 · Cited by 50 · see citing works
Discourse Behaviors in Older Adults
Shadden, B. B. (1997) · Seminars in Speech and Language · doi:10.1055/s-2008-1064069 · Cited by 49 · see citing works
Neuropsychological Subgroups of Patients with Alzheimer's Disease
Fisher, N., Rourke, B. P., Bieliauskas, L. A., Giordani, B., Berent, S., & Foster, N. L. (1996) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639608408993 · Cited by 39 · see citing works
Age at Onset of Alzheimer's Disease
Bayles, K. A. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530140047016 · Cited by 32 · see citing works
Chenery, H. J., & Murdoch, B. E. (1994) · Aphasiology · doi:10.1080/02687039408248648 · Cited by 32 · see citing works
Duong, A., & Ska, B. (2001) · Brain and Cognition · doi:10.1016/s0278-2626(01)80047-6 · Cited by 30 · see citing works
Self-citationDiscourse Analyses and Dementia
Orange, J. B., & Kertesz, A. (2000) · Brain and Language · doi:10.1006/brln.1999.2243 · Cited by 20 · see citing works
Joanette, Y., Ska, B., Poissant, A., et al. (1992) · Springer eBooks · doi:10.1007/978-3-642-46776-9_5 · Cited by 14 · see citing works
Self-citation[Mild cognitive impairments in the elderly: a critical review].
Blanchet, S., McCormick, L. C., Belleville, S., et al. (2002) · PubMed · Cited by 13 · see citing works
Réécrire et apprendre à réécrire : le rôle d'une base de données textuelles
Legros, D., Crinon, J., & Marin-Porta, B. (2006) · Langages · doi:10.3406/lgge.2006.2675 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Linguistic Features Identify Alzheimer’s Disease in Narrative Speech
Fraser, K. C., Meltzer, J. A., & Rudzicz, F. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-150520 · Cited by 797 · see citing works
Connected Speech in Neurodegenerative Language Disorders: A Review
Boschi, V., Catricalà, E., Consonni, M., Chesi, C., Moro, A., & Cappa, S. F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00269 · Cited by 362 · see citing works
Mueller, K. D., Hermann, B., Mecollari, J., & Turkstra, L. S. (2018) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2018.1446513 · Cited by 336 · see citing works
Microlinguistic aspects of the oral narrative in patients with Alzheimer's disease
de Lira, J. O., Ortiz, K. Z., Campanha, A. C., Bertolucci, P. H. F., & Minett, T. S. C. (2011) · International Psychogeriatrics · doi:10.1017/s1041610210001092 · Cited by 137 · see citing works
Connected speech features from picture description in Alzheimer's disease: a systematic review
Slegers, A., Filiou, R.-P., Montembeault, M., & Brambati, S. M. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170881 · Cited by 124 · see citing works
Martinc, M., Haider, F., Pollak, S., & Luz, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.642647 · Cited by 55 · see citing works
“Duong et al. (2005) ran a cluster analysis with data from picture narratives and concluded that, rather than a common profile, there were several discourse patterns that could be indicative of differences between healthy ageing and AD.”
Backgroundde la Fuente Garcia, S., Ritchie, C. W., & Luz, S. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200888 · Cited by 5 · see citing works
- Authors
- Duong, A., Giroux, F., Tardif, A., & Ska, B.
- Affiliations
- Institut Universitaire de Gériatrie de Montréal (CA)
- Université de Montréal (CA)
- Corresponding author
- Duong, Anh
- Venue
- Brain and Language
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 93
- Issue
- 2
- Pages
- 173-184
- ISSN
- 0093-934X (ISSN-L)
- OpenAlex
- W2097236534
- Cited by
- 53
- References
- 52
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain and Language (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université de Montréal
- Fonds de Recherche du Québec - Santé
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- Alzheimer's disease, discourse patterns, discourse processing, cognitive impairment, normal aging, heterogeneity, diagnostic tools, therapeutic tools
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Association Learning, Female, Humans, Imagination, Male, Neuropsychological Tests, Pattern Recognition, Visual, Psycholinguistics, Reference Values, Semantics, Serial Learning, Speech Perception, Verbal Behavior, Cohort Studies, Comprehension
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
