Targeting lipophilic cations to mitochondria
Open accessAbstract
Mitochondrial function and dysfunction contributes to a range of important aspects of biomedical research. Consequently there is considerable interest in developing approaches to modify and report on mitochondria in cells and in vivo. One approach has been to target bioactive molecules to mitochondria by conjugating them to lipophilic cations. Due to the large mitochondrial membrane potential, the cations are accumulated within mitochondria inside cells. This approach had been used to develop mitochondria-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death and also to develop probes of mitochondrial function. Here we outline some of the background to the development of these compounds.
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TPP+ is a delocalized cation that is hydrophobic and can freely pass through phospholipid bilayers of the plasma membrane and other organelles without a specific uptake mechanism.
“This delocalized cation is hydrophobic and can freely pass through the phospholipid bilayers of the plasma membrane and other organelles, without the requirement for a specific uptake mechanism.”
From Mitochondrially targeted compounds and their impact on cellular bioenergetics (2013) · cites this paper as [6]
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- Authors
- Murphy, M. P.
- Affiliations
- MRC Mitochondrial Biology Unit (GB)
- Corresponding author
- Murphy, Michael P.
- ORCID
- Murphy, Michael P.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 1777
- Issue
- 7-8
- Pages
- 1028-1031
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W2070554086
- Cited by
- 598
- References
- 7
- Citations by year
- 2026: 47 · 2025: 42 · 2024: 45 · 2023: 21 · 2022: 37 · 2021: 68 · 2020: 53 · 2019: 40 · 2018: 46 · 2017: 35 · 2016: 29 · 2015: 20 · 2014: 20 · 2013: 18 · 2012: 13
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondria, lipophilic cations, mitochondrial targeting, mitochondrial membrane potential, mitochondria-targeted antioxidants, mitochondrial oxidative damage, cell death, cation accumulation
- MeSH terms
- Adenosine Triphosphate, Antioxidants, Cations, Cell Physiological Phenomena, Cytoplasm, Humans, Membrane Potentials, Mitochondria, Organophosphorus Compounds, Mitochondrial Membranes
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