Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during Ca2+ and succinate-induced oxidative stress in cardiac isolated mitochondria
Open accessAbstract
We hypothesized that NO• is generated in isolated cardiac mitochondria as the source for ONOO- production during oxidative stress. We monitored generation of ONOO- from guinea pig isolated cardiac mitochondria subjected to excess Ca 2+ uptake before adding succinate and determined if ONOO- production was dependent on a nitric oxide synthase (NOS) located in cardiac mitochondria (mtNOS). Mitochondria were suspended in experimental buffer at pH 7.15, and treated with CaCl 2 and then the complex II substrate Na-succinate, followed by menadione, a quinone redox cycler, to generate O 2•-. L-tyrosine was added to the mitochondrial suspension where it is oxidized by ONOO- to form dityrosine (diTyr) in proportion to the ONOO- present. We found that exposing mitochondria to excess CaCl 2 before succinate resulted in an increase in diTyr and amplex red fluorescence (H 2 O 2) signals, indicating that mitochondrial oxidant stress, induced by elevated mtCa 2+ and succinate, increased mitochondrial ONOO- production via NO• and O 2•-. Changes in mitochondrial ONOO- production dependent on NOS were evidenced by using NOS inhibitors L-NAME/L-NNA, TEMPOL, a superoxide dismutase (SOD) mimetic, and PTIO, a potent global NO• scavenger. L-NAME and L-NNA decreased succinate and menadione-mediated ONOO- production, PTIO decreased production of ONOO-, and TEMPOL decreased ONOO- levels by converting more O 2•- to H 2 O 2. Electron microscopy showed immuno-gold labeled iNOS and nNOS in mitochondria isolated from cardiomyocytes and heart tissue. Western blots demonstrated iNOS and nNOS bands in total heart tissue, bands for both iNOS and nNOS in β-tubulin-free non-purified (crude) mitochondrial preparations, and a prominent iNOS band, but no nNOS band, in purified (Golgi and ER-free) mitochondria. Prior treatment of guinea pigs with lipopolysacharride (LPS) enhanced expression of iNOS in liver mitochondria but not in heart mitochondria. Our results indicate that release of ONOO- into the buffer is dependent both on O 2•- released from mitochondria and NO• derived from a mtCa 2+-inducible nNOS isoform, possibly attached to mitochondria, and a mtNOS isoform like iNOS that is non-inducible.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Induction of iNOS usually occurs in the presence of an oxidative environment, which produces peroxynitrite when •NO reacts with superoxide, leading to cellular toxicity.
“Induction of iNOS usually occurs in the presence of an oxidative environment, which produces peroxynitrite when •NO reacts with superoxide [115], leading to cellular toxicity.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [115]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature · doi:10.1038/nature13909 · Cited by 2,907 · cited 4× · see citing works
“We proposed that increased mtCa2+ loading activates a mtNOS to generate NO• [52] and that adding succinate, in the absence of pyruvate, reverses electron transfer at complex I to generate O2 [53].”
InfluentialSuperoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,407 · see citing works
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134 · see citing works
Unraveling peroxynitrite formation in biological systems
Radi, R., Peluffo, G., Alvarez, M. N., Naviliat, M., & Cayota, A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00373-7 · Cited by 735 · see citing works
Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species
Dikalov, S., & Harrison, D. G. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4886 · Cited by 639 · see citing works
Production of Nitric Oxide by Mitochondria
Giulivi, C., Poderoso, J. J., & Boveris, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11038 · Cited by 572 · see citing works
Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis.
Tretter, L., Patócs, A., & Chinopoulos, C. (2016) · Biochimica et Biophysica Acta · doi:10.1016/j.bbabio.2016.03.012 · Cited by 502 · see citing works
Nitric oxide synthase in cardiac sarcoplasmic reticulum
Xu, K. Y., Huso, D. L., Dawson, T. M., Bredt, D. S., & Becker, L. C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.657 · Cited by 480 · see citing works
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
Self-citationMitochondrial nitric oxide synthase
Ghafourifar, P., & Cadenas, E. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.02.005 · Cited by 429 · see citing works
Balligand, J., Kobzik, L., Han, X., Kaye, D. M., Belhassen, L., O’Hara, D. S., Kelly, R. A., Smith, T. W., & Michel, T. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14582 · Cited by 388 · see citing works
The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex
Dröse, S., & Brandt, U. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803236200 · Cited by 386 · see citing works
Kobzik, L., Stringer, B., Balligand, J., Reid, M. B., & Stamler, J. S. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1824 · Cited by 376 · see citing works
Nitric oxide synthase activities in human myocardium
de Belder, A., Why, H. J. F., Richardson, P., Bucknall, C. A., Martin, J., Radomski, M. W., Salas, E., & Moncada, S. (1993) · The Lancet · doi:10.1016/0140-6736(93)92559-c · Cited by 353 · see citing works
Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
Yasmin, W. M. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00254-4 · Cited by 343 · see citing works
Nitrite reductase activity is a novel function of mammalian mitochondria
Kozlov, A. V., Staniek, K., & Nohl, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00788-7 · Cited by 342 · cited 1× · see citing works
“mitochondrial electron transport chain (ETC) is a source of non-enzymatic NO• production via a nitrate reductase/ubiquinone cycle [40,41].”
Kanai, A. J., Pearce, L. L., Clemens, P. R., Birder, L. A., VanBibber, M. M., Choi, S.-Y., de Groat, W. C., & Peterson, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241380298 · Cited by 341 · see citing works
Purification and Characterization of a Nitric-oxide Synthase from Rat Liver Mitochondria
Tatoyan, A., & Giulivi, C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11044 · Cited by 327 · see citing works
Loor, G., Kondapalli, J., Schriewer, J. M., Chandel, N. S., Hoek, T. L. V., & Schumacker, P. T. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.021 · Cited by 304 · see citing works
Systems Biology of Free Radicals and Antioxidants
Laher, I. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9 · Cited by 269 · see citing works
Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?
Bates, T. E., Loesch, A., Burnstock, G., & Clark, J. B. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0008 · Cited by 245 · see citing works
Khan, S. A., Lee, K., Minhas, K. M., González, D. R., Raju, S. V. Y., Tejani, A. D., Li, D., Berkowitz, D. E., & Hare, J. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404136101 · Cited by 227 · see citing works
Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver
Bates, T. E., Loesch, A., Burnstock, G., & Clark, J. B. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2213 · Cited by 204 · see citing works
Pryor, W. A., Cueto, R., Jin, X., Koppenol, W. H., Ngu-Schwemlein, M., Squadrito, G. L., Uppu, P. L., & Uppu, R. M. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00105-s · Cited by 197 · see citing works
An enhanced method for post-embedding immunocytochemical staining which preserves cell membranes.
Berryman, M. A., & Rodewald, R. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.2.1688894 · Cited by 193 · see citing works
Wei, G., Dawson, V. L., & Zweier, J. L. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(99)00051-4 · Cited by 155 · see citing works
Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi
Álvarez, M. N., Piacenza, L., Irigoı́n, F., Peluffo, G., & Radí, R. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.015 · Cited by 136 · see citing works
Lacza, Z. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00754-7 · Cited by 133 · see citing works
Mitochondria recycle nitrite back to the bioregulator nitric monoxide.
Nohl, H., Staniek, K., Sobhian, B., Bahrami, S., Redl, H., & Kozlov, A. V. (2000) · Acta Biochimica Polonica · doi:10.18388/abp.2000_3946 · Cited by 116 · see citing works
Aldakkak, M., Camara, A. K. S., Heisner, J. S., Yang, M., & Stowe, D. F. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.06.018 · Cited by 116 · see citing works
Self-citationTraaseth, N. J., Elfering, S. L., Solien, J., Haynes, V. L., & Giulivi, C. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.04.015 · Cited by 110 · see citing works
Mitochondrial nitric oxide synthase: current concepts and controversies
Lacza, Z. (2009) · Frontiers in bioscience · doi:10.2741/3539 · Cited by 106 · see citing works
The Interaction of Energy and Electron Transfer Reactions in Mitochondria
Chance, B., & Hollunger, G. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64213-9 · Cited by 103 · see citing works
Characteristics and function of cardiac mitochondrial nitric oxide synthase
Dedkova, E. N., & Blatter, L. A. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165423 · Cited by 98 · see citing works
Mitochondrial metabolic states and membrane potential modulate mtNOS activity
Valdez, L. B., Zaobornyj, T., & Boveris, A. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.02.013 · Cited by 94 · see citing works
Calcium Signal Transmission between Ryanodine Receptors and Mitochondria in Cardiac Muscle
Csordás, G. (2001) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00123-2 · Cited by 90 · see citing works
Mitochondrial Inner Membrane Electrophysiology Assessed by Rhodamine-123 Transport and Fluorescence
Huang, M., Camara, A. K. S., Stowe, D. F., Qi, F., & Beard, D. A. (2007) · Annals of Biomedical Engineering · doi:10.1007/s10439-007-9265-2 · Cited by 89 · see citing works
Self-citationOxygen-dependent regulation of nitric oxide production by inducible nitric oxide synthase
Robinson, M. A., Baumgardner, J. E., & Otto, C. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.08.034 · Cited by 84 · see citing works
Nitric oxide synthase in porcine heart mitochondria: evidence for low physiological activity
French, S. A., Giulivi, C., & Balaban, R. S. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2863 · Cited by 84 · see citing works
Purification of a Crude Mitochondrial Fraction by Density‐Gradient Centrifugation
Graham, J. M. (1999) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0304s04 · Cited by 83 · see citing works
Katakam, P. V. G., Wappler-Guzzetta, E. A., Katz, P. S., Rutkai, I., Institóris, Á., Domoki, F., Gáspár, T., Grovenburg, S. M., Snipes, J. A., & Busija, D. W. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300560 · Cited by 83 · see citing works
Hypothermia augments reactive oxygen species detected in the guinea pig isolated perfused heart
Camara, A. K. S., Riess, M. L., Kevin, L. G., Novalija, E., & Stowe, D. F. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00811.2003 · Cited by 81 · see citing works
Self-citationAhmed, L. A., Shehata, N. I., Abdelkader, N. F., & Khattab, M. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108889 · Cited by 77 · see citing works
Strategic localization of heart mitochondrial NOS: a review of the evidence
Zaobornyj, T., & Ghafourifar, P. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00674.2011 · Cited by 77 · see citing works
The powerhouse takes control of the cell; the role of mitochondria in signal transduction
Darley-Usmar, V. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.026 · Cited by 67 · see citing works
Nitric Oxide and Mitochondrial Complex IV
Sarti, P., Arese, M., Bacchi, A., Barone, M. C., Forte, E., Mastronicola, D., Brunori, M., & Giuffrè, A. (2003) · IUBMB Life · doi:10.1080/15216540310001628726 · Cited by 56 · see citing works
Determination of Mitochondrial Nitric Oxide Synthase Activity
Ghafourifar, P., Asbury, M. L., Joshi, S. S., & Kincaid, E. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)96036-9 · Cited by 51 · see citing works
Mammalian mitochondrial nitric oxide synthase: Characterization of a novel candidate
Żemojtel, T., Kolanczyk, M., Kossler, N., Stricker, S., Lurz, R., Mikula, I., Duchniewicz, M., Schuelke, M., Ghafourifar, P., Pavel Martasek, E., et al. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.12.038 · Cited by 50 · see citing works
Miller, M. J. S., Thompson, J. H., Liu, X., Eloby‐Childress, S., Sadowska-Krowicka, H., Zhang, X.-J., & Clark, D. A. (1996) · Inflammation Research · doi:10.1007/bf02280990 · Cited by 49 · see citing works
NOS knockouts and neuroprotection
Grünewald, T., & Beal, M. F. (1999) · Nature Medicine · doi:10.1038/70918 · Cited by 45 · see citing works
Balke, J. E., Zhang, L., & Percival, J. M. (2018) · Nitric Oxide · doi:10.1016/j.niox.2018.11.004 · Cited by 44 · see citing works
Camara, A. K. S., Aldakkak, M., Heisner, J. S., Rhodes, S. S., Riess, M. L., An, J., Heinen, A., & Stowe, D. F. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00231.2006 · Cited by 42 · see citing works
Self-citationDynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release
Blomeyer, C. A., Bazil, J. N., Stowe, D. F., Pradhan, R. K., Dash, R. K., & Camara, A. K. S. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9483-7 · Cited by 41 · see citing works
Self-citationYang, M., Camara, A. K. S., Wakim, B. T., Zhou, Y., Gadicherla, A. K., Kwok, W., & Stowe, D. F. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.06.004 · Cited by 39 · see citing works
Self-citationLindsay, D. P., Camara, A. K. S., Stowe, D. F., Lubbe, R., & Aldakkak, M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00058 · Cited by 38 · see citing works
Self-citationYang, M., Xu, Y., Heisner, J. S., Sun, J., Stowe, D. F., Kwok, W., & Camara, A. K. S. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.10.002 · Cited by 38 · see citing works
Self-citationSuperoxide Generation from Nitric Oxide Synthases
Xia, Y. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1733 · Cited by 36 · see citing works
Yang, M., Camara, A. K. S., Aldakkak, M., Kwok, W., & Stowe, D. F. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2017.03.005 · Cited by 36 · see citing works
Self-citationReiner, M., Bloch, W., & Addicks, K. (2001) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540104901214 · Cited by 35 · see citing works
Aldakkak, M., Stowe, D. F., Dash, R. K., & Camara, A. K. S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.020 · Cited by 30 · see citing works
Self-citationDifferential Modulation of the Cardiac L- and T-type Calcium Channel Currents by Isoflurane
Camara, A. K. S., Begic, Z., Kwok, W., & Bosnjak, Z. J. (2001) · Anesthesiology · doi:10.1097/00000542-200108000-00038 · Cited by 30 · see citing works
Self-citationBlomeyer, C. A., Bazil, J. N., Stowe, D. F., Dash, R. K., & Camara, A. K. S. (2016) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-016-9644-1 · Cited by 29 · see citing works
Self-citationIschemic Preconditioning: Triggering Role of Nitric Oxide-Derived Oxidants in Isolated Hearts
Novalija, E., Hogg, N., Kevin, L. G., Camara, A. K. S., & Stowe, D. F. (2003) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200311000-00003 · Cited by 24 · see citing works
Self-citationMitochondrial nitric oxide production supported by reverse electron transfer
Bombicino, S. S., Iglesias, D. E., Zaobornyj, T., Boveris, A., & Valdez, L. B. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.08.010 · Cited by 23 · see citing works
Klöhn, P., & Neumann, H. (1997) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(97)00052-5 · Cited by 22 · see citing works
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21 · see citing works
The molecular mechanisms by which nitric oxide controls mitochondrial complex IV.
Sarti, P., Arese, M., & Giuffrè, A. (2003) · PubMed · Cited by 14 · see citing works
Ferdinandy, P., & Schulz, R. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100704 · Cited by 12 · see citing works
Stowe, D. F., Boban, M., Roerig, D. L., Chang, D., Palmisano, B. W., & Bosnjak, Z. J. (1997) · Circulation · doi:10.1161/01.cir.95.6.1623 · Cited by 10 · see citing works
Self-citationNitric oxide scavenging modulates mitochondrial dysfunction induced by hypoxia/reoxygenation
Robin, E., Derichard, A., Benoit, V., Hassoun, S. M., & Nevière, R. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70638-7 · Cited by 10 · see citing works
Reactive Oxygen Species (ROS) and Cardiac Ischemia and Reperfusion Injury
Camara, A. K. S., & Stowe, D. F. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_75 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
Piacenza, L., Zeida, A., Trujillo, M., & Radí, R. (2022) · Physiological Reviews · doi:10.1152/physrev.00005.2022 · Cited by 204 · see citing works
Grzeszczak, K., Łanocha-Arendarczyk, N., Malinowski, W., Ziętek, P., & Kosik-Bogacka, D. I. (2023) · Biomolecules · doi:10.3390/biom13121768 · Cited by 199 · see citing works
The Role of Reactive Species on Innate Immunity
Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works
Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation
Kalinina, E. V., & Novichkova, M. (2021) · Molecules · doi:10.3390/molecules26020435 · Cited by 117 · see citing works
Yan, Z., Tang, Z., Wang, X., Zheng, Z., Tian, Z., Geng, X., Li, Y., & Jiang, H. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132352 · Cited by 42 · see citing works
Wang, M., Zhang, M., Bi, J., Li, J., Hu, X., Zhang, L., Zhang, Y., Wang, W., Lin, Y. H., Cheng, H., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c09997 · Cited by 15 · see citing works
OONO–/MMP2/MMP9 pathway-mediated apoptosis of porcine granulosa cells is associated with DNA damage
Lei, K., Wei, Q., Cheng, Y., Wang, Z., Wu, H., Zhao, F., Ding, W., & Shi, F. (2023) · Reproduction · doi:10.1530/rep-22-0295 · Cited by 13 · see citing works
Mishra, J., Bevers, K., Li, K., Zare, A., Heisner, J. S., Tong, A., Kwok, W., Stowe, D. F., & Camara, A. K. S. (2025) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1562065 · Cited by 7 · see citing works
Self-citationAlsiraey, N., & Dewald, H. D. (2024) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2024.112785 · Cited by 6 · see citing works
A big picture of the mitochondria-mediated signals: From mitochondria to organism
Acar, N. V., & Özgül, R. K. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.08.032 · Cited by 2 · see citing works
Process of Oxidative Phosphorylation and Free Radical Generation
Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_6 · Cited by 2 · see citing works
Self-citationBIOLOGICAL ROLE OF REACTIVE OXYGEN SPECIES IN MITOCHONDRIA
Dikal, М. V., Ferenchuk, Y., Bilous, T., Kopchuk, T., Драчук, В. М., & Bilous, V. (2023) · Clinical anatomy and operative surgery · doi:10.24061/1727-0847.22.2.2023.24 · Cited by 2 · see citing works
Yin, B., Liu, H., Tan, B., Dong, X., Chi, S., Yang, Q., & Zhang, S. (2020) · Research Square · doi:10.21203/rs.3.rs-130234/v1
Gastroduodenal syndrome in rats under stress and possible ways of correcting disorders
Gildikov, D. I., & Baymatov, V. N. (2023) · AIP conference proceedings · doi:10.1063/5.0148370
Glutathione: Chemistry and Biochemistry
Perjési, P. (2023) · MDPI eBooks · doi:10.3390/books978-3-0365-8666-3
Intracellular signaling mechanisms of acetaminophen-induced cell death
Ramachandran, A., McGill, M. R., & Jaeschke, H. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15877-3.00017-x
Regulation of Bioenergetics in Cardiac Myocytes
Stowe, D. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-76668-8_8
Self-citationYang, H. W., Park, M. K., Jeong, H. H., & Suh, S. W. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104173
Mishra, J., Krier, C., Cavanaugh, M., Asija, A., Baker, J. E., Kwok, W., Camara, A. K. S., & Fitts, R. H. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00108.2026
Self-citation
- Authors
- Gerdes, H. J., Yang, M., Heisner, J. S., Camara, A. K. S., & Stowe, D. F.
- Affiliations
- Medical College of Wisconsin (US)
- Marquette University (US)
- Corresponding author
- Stowe, David F.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 1861
- Issue
- 12
- Pages
- 148290
- ISSN
- 0005-2728 (ISSN-L)
- PMC
- PMC7560995
- OpenAlex
- W3081476062
- Cited by
- 19
- References
- 73
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 1 · 2020: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health (5T35 HL072483-34)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- peroxynitrite, mitochondrial nitric oxide synthase, inducible nitric oxide synthase, neuronal nitric oxide synthase, heart mitochondria, oxidative stress, calcium overload, succinic acid, superoxide, nitric oxide, dityrosine, menadione, L-NAME, L-NNA, PTIO, tempol, lipopolysaccharide, cardiomyocytes, mitochondrial calcium, superoxide dismutase
- MeSH terms
- Animals, Calcium, Electron Transport, Guinea Pigs, Hydrogen Peroxide, Isoenzymes, Mitochondria, Heart, Nitric Oxide, Spectrometry, Fluorescence, Stress, Physiological, Superoxide Dismutase, Time Factors, Free Radical Scavengers, Oxidative Stress, Nitric Oxide Synthase, Succinic Acid, Peroxynitrous Acid, Membrane Potential, Mitochondrial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
