Unraveling peroxynitrite formation in biological systems

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

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The L-Arginine-Nitric Oxide Pathway

Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678 · see citing works

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works

Superoxide radical and superoxide dismutases

Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455 · see citing works

Peroxynitrite oxidation of sulfhydryls.

Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492 · see citing works

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,407 · see citing works

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

Radí, R., Beckman, J. S., Bush, K. M., & Freeman, B. Α. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90224-7 · Cited by 2,196 · see citing works

The reaction of NO with superoxide

Huie, R. E., & Padmaja, S. (1993) · Free Radical Research Communications · doi:10.3109/10715769309145868 · Cited by 2,121 · see citing works

Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide

Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606 · see citing works

The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide

Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511 · see citing works

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496 · see citing works

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,495 · see citing works

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives

Rubbo, H., Radí, R., Trujillo, M., Telleri, R., Kalyanaraman, B., Barnes, S., KIRK, M. C., & Freeman, B. Α. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47160-8 · Cited by 1,350 · see citing works

Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide

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Evaluation of 2′,7′-Dichlorofluorescin and Dihydrorhodamine 123 as Fluorescent Probes for Intracellular H2O2 in Cultured Endothelial Cells

Royall, J. A., & Ischiropoulos, H. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1222 · Cited by 1,123 · see citing works

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

Beckman, J. S., Ye, Y. Z., Anderson, P. G., Chen, J., Accavitti, M. A., Tarpey, M. M., & White, C. R. (1994) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1994.375.2.81 · Cited by 1,122 · see citing works

Peroxynitrite formation from macrophage-derived nitric oxide

Ischiropoulos, H., Zhu, L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90433-w · Cited by 1,099 · see citing works

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

Ischiropoulos, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0755 · Cited by 1,024 · see citing works

ALS, SOD and peroxynitrite

Beckman, J. S., Carson, M. A., Smith, C. D. L., & Koppenol, W. H. (1993) · Nature · doi:10.1038/364584a0 · Cited by 876 · see citing works

Persistent inhibition of cell respiration by nitric oxide: Crucial role of <i>S</i> -nitrosylation of mitochondrial complex I and protective action of glutathione

Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7631 · Cited by 863 · see citing works

Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

Squadrito, G. L., & Pryor, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00095-1 · Cited by 795 · see citing works

Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite

van der Vliet, A., Eiserich, J. P., Halliwell, B., & Cross, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7617 · Cited by 780 · see citing works

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

MacMillan-Crow, L.-A., Crow, J. P., Kerby, J. D., Beckman, J. S., & Thompson, J. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11853 · Cited by 768 · see citing works

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

Beckman, J. S., Ischiropoulos, H., Zhu, L., van der Woerd, M., Smith, C. D. L., Chen, J., Harrison, J. G., Martin, J. C., & Tsai, M. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90432-v · Cited by 765 · see citing works

Differential Inhibitory Action of Nitric Oxide and Peroxynitrite on Mitochondrial Electron Transport

Cassina, A., & Radí, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0178 · Cited by 725 · see citing works

Peroxynitrite-mediated oxidation of dihydrorhodamine 123

Kooy, N. W., Royall, J. A., Ischiropoulos, H., & Beckman, J. S. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90138-4 · Cited by 720 · see citing works

Evidence for nitric oxide‐mediated oxidative damage in chronic inflammation Nitrotyrosine in serum and synovial fluid from rheumatoid patients

Kaur, H., & Halliwell, B. B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00722-5 · Cited by 706 · see citing works

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

Radi, R., Rodriguez, M., Castro, L., & Telleri, R. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1013 · Cited by 693 · see citing works

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

Xia, Y., & Zweier, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6954 · Cited by 691 · see citing works

Simulation of the diffusion and reaction of endogenously produced nitric oxide.

Lancaster, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8137 · Cited by 689 · see citing works

“NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms

Keefer, L. K., Nims, R. W., Davies, K. M., & Wink, D. A. (1996) · Methods in Enzymology · doi:10.1016/s0076-6879(96)68030-6 · Cited by 670 · see citing works

Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis

Kissner, R., Nauser, T., Bugnon, P., Lye, P. G., & Koppenol, W. H. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970160x · Cited by 629 · see citing works

Dichlorodihydrofluorescein and Dihydrorhodamine 123 Are Sensitive Indicators of Peroxynitritein Vitro:Implications for Intracellular Measurement of Reactive Nitrogen and Oxygen Species

Crow, J. P. (1997) · Nitric Oxide · doi:10.1006/niox.1996.0113 · Cited by 627 · see citing works

Peroxynitrite‐mediated oxidative protein modifications

Ischiropoulos, H., & Al‐Mehdi, A. B. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00307-u · Cited by 610 · see citing works

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

Beal, M. F., Ferrante, R. J., Browne, S. E., Matthews, R. T., Kowall, N. W., & Brown, R. H. (1997) · Annals of Neurology · doi:10.1002/ana.410420416 · Cited by 599 · see citing works

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

Estévez, A. G., Crow, J. P., Sampson, J. B., Reiter, C., Zhuang, Y., Richardson, G. J., Tarpey, M. M., Barbeito, L., & Beckman, J. S. (1999) · Science · doi:10.1126/science.286.5449.2498 · Cited by 596 · see citing works

Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

Haddad, I. Y., Pataki, G., Yu, Y., GALLIANI, C. A., Beckman, J. S., & Matalon, S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117607 · Cited by 594 · see citing works

Peroxynitrite reaction with carbon dioxide/bicarbonate. Kinetics and influence on peroxynitrite-mediated oxidations

Denicola, A., Freeman, B. A., Trujillo, M., & Radi, R. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0363 · Cited by 593 · see citing works

Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis

Hooper, D. C., Spitsin, S. V., Kean, R. B., Champion, J. M., Dickson, G. M., Chaudhry, I., & Koprowski, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.675 · Cited by 569 · see citing works

Rapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity

Lymar, S. V., & Hurst, J. K. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00139a027 · Cited by 515 · see citing works

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

Hensley, K., Maidt, M. L., Yu, Z., Sang, H., Markesbery, W. R., & Floyd, R. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08126.1998 · Cited by 508 · see citing works

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S. H., Marino, M., Fang, F. C., Dinauer, M. C., & Nathan, C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80004-7 · Cited by 504 · see citing works

Evidence for In Vivo Peroxynitrite Production in Human Acute Lung Injury

Kooy, N. W., Royall, J. A., Ye, Y. Z., Kelly, D. R., & Beckman, J. S. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.4.1250 · Cited by 503 · see citing works

A Nonpeptidyl Mimic of Superoxide Dismutase with Therapeutic Activity in Rats

Salvemini, D., Wang, Z., Zweier, J. L., Samouilov, A., Macarthur, H., Misko, T. P., Currie, M. G., Cuzzocrea, S., Sikorski, J. A., & Riley, D. P. (1999) · Science · doi:10.1126/science.286.5438.304 · Cited by 502 · see citing works

Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.

Akaike, T., Noguchi, Y., Ijiri, S., Setoguchi, K., Suga, M., Zheng, Y., Dietzschold, B., & Maeda, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2448 · Cited by 490 · see citing works

THE PATHOPHYSIOLOGICAL ROLE OF PEROXYNITRITE IN SHOCK, INFLAMMATION, AND ISCHEMIA-REPERFUSION INJURY

Szabó, C. (1996) · Shock · doi:10.1097/00024382-199608000-00001 · Cited by 481 · see citing works

Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1

Stuehr, D. J., Fasehun, O. A., Kwon, N. S., Gross, S. S., Gonzalez, J. A., Levi, R., & Nathan, C. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.1.1703974 · Cited by 465 · see citing works

Effects of peroxynitrite‐induced protein modifications on tyrosine phosphorylation and degradation

Gow, A. J., Duran, D., Malcolm, S., & Ischiropoulos, H. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00347-x · Cited by 449 · see citing works

Inactivation of Human Manganese-superoxide Dismutase by Peroxynitrite Is Caused by Exclusive Nitration of Tyrosine 34 to 3-Nitrotyrosine

Yamakura, F., Taka, H., Fujimura, T., & Murayama, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14085 · Cited by 442 · see citing works

Expression of phagocyte NADPH oxidase components in human endothelial cells

Jones, S. A., O’Donnell, V. B., Wood, J. D., Broughton, J. P., Hughes, E. J., & Jones, O. T. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.4.h1626 · Cited by 427 · see citing works

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

Murray, H. W., & Nathan, C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.741 · Cited by 418 · see citing works

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Ara, J. E., Przedborski, S., Naini, A., Jackson-Lewis, V. R., Trifiletti, R. R., Horwitz, J., & Ischiropoulos, H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7659 · Cited by 414 · see citing works

Diffusion of peroxynitrite across erythrocyte membranes

Denicola, A., Souza, J. M., & Radi, R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3566 · Cited by 403 · see citing works

The reaction of NO· with O2·− and HO2·−: A pulse radiolysis study

Goldstein, S., & Czapski, G. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00034-u · Cited by 398 · see citing works

Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase:

Rota, C., Chignell, C. F., & Mason, R. P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00137-9 · Cited by 383 · see citing works

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

van der Vliet, A., O’neill, C. A., Halliwell, B. B., Cross, C. E., & Kaur, H. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80391-9 · Cited by 381 · see citing works

Peroxynitrite-induced luminol chemiluminescence

Radí, R., Cosgrove, T. P., Beckman, J. S., & Freeman, B. Α. (1993) · Biochemical Journal · doi:10.1042/bj2900051 · Cited by 377 · see citing works

Tyrosine Modification by Reactive Nitrogen Species: A Closer Look

Vandervliet, A., Eiserich, J. P., O’Neill, C., Halliwell, B. B., & Cross, C. E. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1303 · Cited by 373 · see citing works

Permeation of the erythrocyte stroma by superoxide radical

Lynch, R. E., & Fridovich, I. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30446-5 · Cited by 370 · see citing works

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

White, C. R., Darley-Usmar, V, Berrington, W. R., McAdams, M., Gore, J. Z., Thompson, J. A., Parks, D. A., Tarpey, M. M., & Freeman, B. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8745 · Cited by 367 · see citing works

Neuronal Nitric Oxide Synthase Activation and Peroxynitrite Formation in Ischemic Stroke Linked to Neural Damage

Eliasson, M. J. L., Huang, Z., Ferrante, R. J., Sasamata, M., Molliver, M. E., Snyder, S. H., & Moskowitz, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05910.1999 · Cited by 366 · see citing works

Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination

Yermilov, V., Rubio, J., & Ohshima, H. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01281-6 · Cited by 356 · see citing works

Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

Miles, A. M., Bohle, D. S., Glassbrenner, P. A., Hansert, B., Wink, D. A., & Grisham, M. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.40 · Cited by 352 · see citing works

Nitric Oxide and Superoxide Contribute to Motor Neuron Apoptosis Induced by Trophic Factor Deprivation

Estévez, Á. G., Spear, N., Manuel, S. M., Radí, R., Henderson, C. E., Barbeito, L., & Beckman, J. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-03-00923.1998 · Cited by 344 · see citing works

Luminol and lucigenin as detectors for O2ṡ−

Faulkner, K. M., & Fridovich, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90044-u · Cited by 342 · see citing works

Prevention of experimental allergic encephalomyelitis by targeting nitric oxide and peroxynitrite: Implications for the treatment of multiple sclerosis

Hooper, D. C., Bagasra, O., Marini, J. C., Zborek, A., Ohnishi, S. T., Kean, R. B., Champion, J. M., Sarker, A. B., Bobroski, L. E., Farber, J. L., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2528 · Cited by 333 · see citing works

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

Lizasoaín, I., Moro, M. Á., Knowles, R. G., Darley-Usmar, V. M., & Moncada, S. (1996) · Biochemical Journal · doi:10.1042/bj3140877 · Cited by 318 · see citing works

Factors Determining the Selectivity of Protein Tyrosine Nitration

Souza, J. M., Daikhin, E., Yudkoff, M., Raman, C. S., & Ischiropoulos, H. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1480 · Cited by 315 · see citing works

Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.

Evans, T. J., Buttery, L. D. K., Carpenter, A., Springall, D. R., Polak, J. M., & Cohen, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9553 · Cited by 311 · see citing works

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

Brito, C., Naviliat, M., Tiscornia, A., Vuillier, F., Gualco, G., Dighiero, G., Radí, R., & Cayota, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3356 · Cited by 306 · see citing works

Peroxynitrite rapidly permeates phospholipid membranes

Marla, S. S., Lee, J., & Groves, J. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14243 · Cited by 306 · see citing works

Carbon Dioxide Enhancement of Peroxynitrite-Mediated Protein Tyrosine Nitration

Gow, A. J., Duran, D., Thom, S. R., & Ischiropoulos, H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0362 · Cited by 302 · see citing works

Mechanism of carbon dioxide-catalyzed oxidation of tyrosine by peroxynitrite

Lymar, S. V., Jiang, Q., & Hurst, J. K. (1996) · Biochemistry · doi:10.1021/bi960331h · Cited by 299 · see citing works

Direct EPR Detection of the Carbonate Radical Anion Produced from Peroxynitrite and Carbon Dioxide

Bonini, M. G., Radi, R., Ferrer-Sueta, G., Ferreira, A. M. D. C., & Augusto, O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10802 · Cited by 293 · see citing works

Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant

Bruijn, L. I., Beal, M. F., Bêcher, M. W., Schulz, J. B., Wong, P. C., Price, D. L., & Cleveland, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7606 · Cited by 290 · see citing works

Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion

O'Donnell, V. B., Eiserich, J. P., Chumley, P. H., Jablonsky, M. J., Krishna, N. R., Kirk, M., Barnes, S., Darley-Usmar, V. M., & Freeman, B. A. (1999) · Chemical Research in Toxicology · doi:10.1021/tx980207u · Cited by 289 · see citing works

Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite

Hughes, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00019-5 · Cited by 288 · see citing works

2,7‐Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation

Possel, H., Noack, H., Augustin, W., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01197-6 · Cited by 284 · see citing works

Nitric oxide :principles and actions

Lancaster, J. R. (1996) · Cited by 283 · see citing works

Uric Acid Oxidation by Peroxynitrite: Multiple Reactions, Free Radical Formation, and Amplification of Lipid Oxidation

Santos, C. X. C., Anjos, E. I., & Augusto, O. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1491 · Cited by 275 · see citing works

An activity in rat tissues that modifies nitrotyrosine-containing proteins

Kamisaki, Y., Wada, K., Bian, K., Balabanlı, B., Davis, K. L., Martin, E., Behbod, F., Lee, Y.-C., & Murad, F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11584 · Cited by 275 · see citing works

Manganese Superoxide Dismutase Protects nNOS Neurons from NMDA and Nitric Oxide-Mediated Neurotoxicity

Gonzalez‐Zulueta, M., Ensz, L. M., Mukhina, G. L., Lebovitz, R. M., Zwacka, R. M., Engelhardt, J. F., Oberley, L. W., Dawson, V. L., & Dawson, T. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02040.1998 · Cited by 265 · see citing works

Mass Spectrometric Quantification of 3-Nitrotyrosine, ortho-Tyrosine, and o,o′-Dityrosine in Brain Tissue of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated Mice, a Model of Oxidative Stress in Parkinson's Disease

Pennathur, S., Jackson-Lewis, V. R., Przedborski, S., & Heinecke, J. W. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34621 · Cited by 265 · see citing works

Eosinophil peroxidase nitrates protein tyrosyl residues

Wu, W., Chen, Y., & Hazen, S. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25933 · Cited by 265 · see citing works

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

Troy, C. M., Derossi, D., Prochiantz, A., Greene, L., & Shelanski, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00253.1996 · Cited by 264 · see citing works

Kinetics and mechanism of the reduction of ferricytochrome c by the superoxide anion.

Butler, J., Koppenol, W. H., & Margoliash, E. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33886-9 · Cited by 261 · see citing works

Peroxynitrite-Dependent Tryptophan Nitration

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Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite

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Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase

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Xanthine Oxidase-mediated Decomposition of S-Nitrosothiols

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Glyceraldehyde-3-Phosphate Dehydrogenase Inactivation by Peroxynitrite

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Spin-Trapping Studies of Peroxynitrite Decomposition and of 3-Morpholinosydnonimine N-Ethylcarbamide Autooxidation: Direct Evidence for Metal-Independent Formation of Free-Radical Intermediates

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Mercaptoethylguanidine and Guanidine Inhibitors of Nitric-oxide Synthase React with Peroxynitrite and Protect against Peroxynitrite-induced Oxidative Damage

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The Nitric Oxide/Superoxide Assay

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Mechanisms of Iron Porphyrin Reactions with Peroxynitrite

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Base Modification and Strand Breakage in Isolated Calf Thymus DNA and in DNA from Human Skin Epidermal Keratinocytes Exposed to Peroxynitrite or 3-Morpholinosydnonimine

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Dityrosine Formation Outcompetes Tyrosine Nitration at Low Steady-state Concentrations of Peroxynitrite

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Nitration and Hydroxylation of Phenolic Compounds by Peroxynitrite

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Catalytic Scavenging of Peroxynitrite by Isomeric Mn(III) N -Methylpyridylporphyrins in the Presence of Reductants

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CO2-Catalyzed One-Electron Oxidations by Peroxynitrite: Properties of the Reactive Intermediate

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Hydrogen Peroxide Formation by Reaction of Peroxynitrite with HEPES and Related Tertiary Amines

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Nitric Oxide Synthase Inhibitors Preclinical Studies of Potential Use for Treatment of Opioid Withdrawal

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In Vivo Aspects of Nitric Oxide (NO) Chemistry: Does Peroxynitrite (-OONO) Play a Major Role in Cytotoxicity?

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Evidence for iNOS-dependent peroxynitrite production in diabetic platelets

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Direct and Indirect Oxidations by Peroxynitrite

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Nitration of surfactant protein A results in decreased ability to aggregate lipids

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Detection of 3-Nitrotyrosine in Human Platelets Exposed to Peroxynitrite by a New Gas Chromatography/Mass Spectrometry Assay

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Differing Effects of Copper, Zinc Superoxide Dismutase Overexpression on Neurotoxicity Elicited by Nitric Oxide, Reactive Oxygen Species, and Excitotoxins

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Ternary Copper Complexes and Manganese(III) Tetrakis(4-benzoic acid)porphyrin Catalyze Peroxynitrite-Dependent Nitration of Aromatics

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Peroxynitrite-Mediated Nitration of Peptides: Characterization of the Products by Electrospray and Combined Gas Chromatography–Mass Spectrometry

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The Reaction of 2-(Methylseleno)benzanilide with Peroxynitrite

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Reaction of Peroxynitrite with HEPES or MOPS Results in the Formation of Nitric Oxide Donors

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Nitric oxide synthase inhibitors decrease human polymorphonuclear leukocyte luminol-dependent chemiluminescence

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Nitric Oxide and Peroxynitrite in Health and Disease

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Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration

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Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

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Delayed production of free radicals following noise exposure

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Familial Amyloid Polyneuropathy: Receptor for Advanced Glycation End Products-Dependent Triggering of Neuronal Inflammatory and Apoptotic Pathways

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The neglected significance of “antioxidative stress”

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The Role of Reactive Species on Innate Immunity

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Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite

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What really happens in the neutrophil phagosome?

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Influence of vitamin C and vitamin E on redox signaling: implications for exercise adaptations

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Peroxynitrite Detoxification and Its Biologic Implications

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Tyrosine-nitrated proteins: Proteomic and bioanalytical aspects

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Inhibition of PTEN by peroxynitrite activates the phosphoinositide‐3‐kinase/Akt neuroprotective signaling pathway

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Impact of Reactive Species on Amino Acids—Biological Relevance in Proteins and Induced Pathologies

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Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress

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