The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins
Open accessAbstract
Programmed cell death or apoptosis is central to many physiological processes and pathological conditions such as organogenesis, tissue homeostasis, cancer, and neurodegenerative diseases. Bcl-2 family proteins tightly control this cell death program by regulating the permeabilization of the mitochondrial outer membrane and, hence, the release of cytochrome c and other pro-apoptotic factors. Control of the formation of the mitochondrial apoptosis-induced channel, or MAC, is central to the regulation of apoptosis by Bcl-2 family proteins. MAC is detected early in apoptosis by patch clamping the mitochondrial outer membrane. The focus of this review is on the regulation of MAC activity by Bcl-2 family proteins. The role of MAC as the putative cytochrome c release channel during early apoptosis and insights concerning its molecular composition are also discussed.
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“Remarkably, cyclophilin-D deficient cells died normally in response to apoptotic stimuli known to activate both the extrinsic and intrinsic pathways, but showed resistance to necrotic cell death induced by reactive oxygen species and Ca overload [12].”
BackgroundVDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis
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Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D
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“However, it was recently shown that sustained PTP opening is primarily involved in necrosis and ischemia–reperfusion [12–14].”
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Mechanisms of Acetaminophen-Induced Liver Necrosis
Hinson, J. A., Roberts, D. W., & James, L. P. (2010) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-00663-0_12 · Cited by 1,006
VDAC, a multi-functional mitochondrial protein regulating cell life and death
Shoshan-Barmatz, V., De Pinto, V., Zweckstetter, M., Raviv, Z., Keinan, N., & Arbel, N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.03.002 · Cited by 782
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Powers, S. K., Kavazis, A. N., & McClung, J. M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01202.2006 · Cited by 472
Maier, P., Hartmann, L., Wenz, F., & Herskind, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010102 · Cited by 414
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Metadata
- Authors
- Dejean, L. M., Martinez-Caballero, S., Manon, S., & Kinnally, K. W.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 1762
- Issue
- 2
- Pages
- 191-201
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2097088463
- Cited by
- 200
- References
- 6
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Dejean, L. M., Martinez-Caballero, S., Manon, S., & Kinnally, K. W. (2006). Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/j.bbadis.2005.07.002
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