The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Mitochondrial Ion Channels
Open accessAbstract
In work spanning more than a century, mitochondria have been recognized for their multifunctional roles in metabolism, energy transduction, ion transport, inheritance, signaling, and cell death. Foremost among these tasks is the continuous production of ATP through oxidative phosphorylation, which requires a large electrochemical driving force for protons across the mitochondrial inner membrane. This process requires a membrane with relatively low permeability to ions to minimize energy dissipation. However, a wealth of evidence now indicates that both selective and nonselective ion channels are present in the mitochondrial inner membrane, along with several known channels on the outer membrane. Some of these channels are active under physiological conditions, and others may be activated under pathophysiological conditions to act as the major determinants of cell life and death. This review summarizes research on mitochondrial ion channels and efforts to identify their molecular correlates. Except in a few cases, our understanding of the structure of mitochondrial ion channels is limited, indicating the need for focused discovery in this area.
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The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
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Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D
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Enigma of the peripheral benzodiazepine receptor
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The causes and functions of mitochondrial proton leak
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Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation
Koopman, W. J. H., Nijtmans, L. G. J., Dieteren, C. E. J., Roestenberg, P., Valsecchi, F., Smeitink, J. A. M., & Willems, P. H. G. M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2743 · Cited by 411
Injection of isolated mitochondria during early reperfusion for cardioprotection
McCully, J. D., Cowan, D. B., Pacak, C. A., Toumpoulis, I. K., Dayalan, H., & Levitsky, S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00567.2008 · Cited by 375
Gouspillou, G., Bourdel-Marchasson, I., Rouland, R., Calmettes, G., Franconi, J.-M., Deschodt-Arsac, V., & Diolez, P. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.09.004 · Cited by 62
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Metadata
- Authors
- O’Rourke, B.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2007-03-01
- Volume
- 69
- Issue
- 1
- Pages
- 19-49
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2156826654
- Cited by
- 310
- References
- 14
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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