The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Targeting antioxidants to mitochondria: A new therapeutic direction
Open accessAbstract
Mitochondria play an important role in controlling the life and death of a cell. Consequently, mitochondrial dysfunction leads to a range of human diseases such as ischemia-reperfusion injury, sepsis, and diabetes. Although the molecular mechanisms responsible for mitochondria-mediated disease processes are not fully elucidated yet, the oxidative stress appears to be critical. Accordingly, strategies are being developed for the targeted delivery of antioxidants to mitochondria. In this review, we shall briefly discuss cellular reactive oxygen species metabolism and its role in pathophysiology; the currently existing antioxidants and possible reasons why they are not effective in ameliorating oxidative stress-mediated diseases; and recent developments in mitochondrially targeted antioxidants and their future promise for disease treatment.
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Cites
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Cited by
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Cisplatin: The first metal based anticancer drug
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Metadata
- Authors
- Sheu, S.-S., Nauduri, D., & Anders, M. W.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 1762
- Issue
- 2
- Pages
- 256-265
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2117696416
- Cited by
- 414
- References
- 57
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sheu, S.-S., Nauduri, D., & Anders, M. W. (2006). Targeting antioxidants to mitochondria: A new therapeutic direction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/j.bbadis.2005.10.007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
