The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
Open accessAbstract
The cause(s) of amyotrophic lateral sclerosis (ALS) is not fully understood in the vast majority of cases and the mechanisms involved in motor neuron degeneration are multi-factorial and complex. There is substantial evidence to support the hypothesis that oxidative stress is one mechanism by which motor neuron death occurs. This theory becomes more persuasive with the discovery that mutation of the anti-oxidant enzyme, superoxide dismutase 1 (SOD1), causes disease in a significant minority of cases. However, the precise mechanism(s) by which mutant SOD1 leads to motor neuron degeneration have not been defined with certainty, and trials of anti-oxidant therapies have been disappointing. Here, we review the evidence implicating oxidative stress in ALS pathogenesis, discuss how oxidative stress may affect and be affected by other proposed mechanisms of neurodegeneration, and review the trials of various anti-oxidants as potential therapies for ALS.
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Cites
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Cited by
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Self-citation
Metadata
- Authors
- Barber, S. C., Mead, R. J., & Shaw, P. J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 1762
- Issue
- 11-12
- Pages
- 1051-1067
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2150095505
- Cited by
- 474
- References
- 202
- FWCI
- 15.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Barber, S. C., Mead, R. J., & Shaw, P. J. (2006). Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. https://doi.org/10.1016/j.bbadis.2006.03.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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