The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
TRP channels in disease
Open accessAbstract
"Transient receptor potential" cation channels (TRP channels) play a unique role as cell sensors, are involved in a plethora of Ca(2+)-mediated cell functions, and play a role as "gate-keepers" in many homeostatic processes such as Ca(2+) and Mg(2+) reabsorption. The variety of functions to which TRP channels contribute and the polymodal character of their activation predict that failures in correct channel gating or permeation will likely contribute to complex pathophysiological mechanisms. Dysfunctions of TRPs cause human diseases but are also involved in a complex manner to contribute and determine the progress of several diseases. Contributions to this special issue discuss channelopathias for which mutations in TRP channels that induce "loss-" or "gain-of-function" of the channel and can be considered "disease-causing" have been identified. The role of TRPs will be further elucidated in complex diseases of the intestinal, renal, urogenital, respiratory, and cardiovascular systems. Finally, the role of TRPs will be discussed in neuronal diseases and neurodegenerative disorders.
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Citations
Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Hofmann, T., Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T., & Schultz, G. (1999) · Nature · doi:10.1038/16711 · Cited by 1,495
Transient Receptor Potential Cation Channels in Disease
Nilius, B., Owsianik, G., Voets, T., & Peters, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00021.2006 · Cited by 1,399
Self-citationThe TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
The TRP Channels, a Remarkably Functional Family
Montell, C., Birnbaumer, L., & Flockerzi, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00670-0 · Cited by 877
Pedersen, S. F., Owsianik, G., & Nilius, B. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.028 · Cited by 774
Self-citationA Unified Nomenclature for the Superfamily of TRP Cation Channels
Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R. J., Bruford, E. A., Caterina, M. J., Clapham, D. E., Harteneck, C., Heller, S., Julius, D., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00448-3 · Cited by 672
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, K., Wang, Y., McAnally, J., Richardson, J. A., Bassel-Duby, R., Hill, J. A., & Olson, E. N. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27702 · Cited by 561
Structure and function of TRPV1
Tominaga, M., & Tominaga, T. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1457-8 · Cited by 415
Ashcroft, F. M. (2006) · Nature · doi:10.1038/nature04707 · Cited by 403
Cited by
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
Kremeyer, B., Lopera, F., Cox, J. J., Momin, A., Rugiero, F., Marsh, S., Woods, C. G., Jones, N. G., Paterson, K. J., Fricker, F. R., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.030 · Cited by 443
Yang, D., Luo, Z., Ma, S., Wong, W. T., Ma, L., Zhong, J., He, H., Zhao, Z., Cao, T., Yan, Z., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.015 · Cited by 349
The vanilloid transient receptor potential channel TRPV4: From structure to disease
Everaerts, W., Nilius, B., & Owsianik, G. (2010) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2009.10.002 · Cited by 347
Self-citationTRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
Cao, E., Cordero-Morales, J. F., Liu, B., Qin, F., & Julius, D. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.016 · Cited by 340
Metadata
- Authors
- Nilius, B.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 1772
- Issue
- 8
- Pages
- 805-812
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W3023991356
- Cited by
- 316
- References
- 53
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
