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Inflammation, demyelination, and degeneration — Recent insights from MS pathology
Open accessAbstract
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which responds to anti-inflammatory treatments in the early disease phase. However, the pathogenesis of the progressive disease phase is less well understood, and inflammatory as well as neurodegenerative mechanisms of tissue damage are currently being discussed. This review summarizes current knowledge on the interrelation between inflammation, demyelination, and neurodegeneration derived from the study of human autopsy and biopsy brain tissue and experimental models of MS.
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“In animal models, demyelination can be triggered by the accumulation of amyloid-beta peptides, phosphorylated Tau, or proinflammatory cytokines (35–37).”
From Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease (2020) · cites this paper as [37]
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Metadata
- Authors
- Stadelmann, C., Wegner, C., & Brück, W.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Stadelmann, Christine
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 1812
- Issue
- 2
- Pages
- 275-282
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2108088418
- Cited by
- 276
- References
- 117
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 16 · 2023: 13 · 2022: 26 · 2021: 14 · 2020: 17 · 2019: 27 · 2018: 19 · 2017: 22 · 2016: 22 · 2015: 17 · 2014: 14 · 2013: 22 · 2012: 16
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- GRO (submittedVersion, cc-by)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, neuroinflammation, demyelination, neurodegeneration, progressive multiple sclerosis, central nervous system, autopsy brain tissue, pathogenesis
- MeSH terms
- Animals, Autoantigens, Axons, Demyelinating Diseases, Humans, Inflammation, Multiple Sclerosis, Nerve Degeneration, Neurons, Autoimmunity
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