Inflammation, demyelination, and degeneration — Recent insights from MS pathology

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288

The spectrum of neuromyelitis optica

Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70216-8 · Cited by 2,182

Cortical demyelination and diffuse white matter injury in multiple sclerosis

Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836

Multiple sclerosis--the plaque and its pathogenesis.

Frohman, E., Racke, M., & Raine, C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052130 · Cited by 1,793

Axonal damage in acute multiple sclerosis lesions

Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology

Magliozzi, R., Howell, O. W., Vora, A., Serafini, B., Nicholas, R. S., Puopolo, M., Reynolds, R., & Aloisi, F. (2006) · Brain · doi:10.1093/brain/awm038 · Cited by 1,486

The relation between inflammation and neurodegeneration in multiple sclerosis brains

Frischer, J. M., Bramow, S., Dal-Bianco, A., Lucchinetti, C. F., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., & Lassmann, H. (2009) · Brain · doi:10.1093/brain/awp070 · Cited by 1,450

Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions

Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.

Lucchinetti, C., Mandler, R., McGavern, D., Brück, W., Gleich, G., Ransohoff, R., Trebst, C., Weinshenker, B., Wingerchuk, D., Parisi, J., et al. (2002) · Brain : a journal of neurology · doi:10.1093/brain/awf151 · Cited by 1,228

Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion

Barnett, M. H., & Prineas, J. W. (2004) · Annals of Neurology · doi:10.1002/ana.20016 · Cited by 1,184

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis

Bridel, C., van Wieringen, W. N., Zetterberg, H., Tijms, B. M., Teunissen, C. E., and the NFL Group, Alvarez-Cermeño, J. C., Andreasson, U., Axelsson, M., Bäckström, D. C., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1534 · Cited by 764

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551

Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain

Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008762117 · Cited by 476

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

Skripuletz, T., Hackstette, D., Bauer, K., Gudi, V., Pul, R., Voss, E., Berger, K., Kipp, M., Baumgärtner, W., & Stangel, M. (2013) · Brain · doi:10.1093/brain/aws262 · Cited by 376

Review: The role of vitamin D in nervous system health and disease

DeLuca, G. C., Kimball, S., Kolasinski, J., Ramagopalan, S. V., & Ebers, G. C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12020 · Cited by 340

Phytocannabinoids as novel therapeutic agents in {CNS} disorders.

Hill, A. J., Williams, C. M., Whalley, B. J., & Stephens, G. J. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.002 · Cited by 312

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

van der Poel, M., Ulas, T., Mizee, M. R., Hsiao, C.-C., Miedema, S. S. M., Adelia, Schuurman, K. G., Helder, B., Tas, S. W., Schultze, J. L., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08976-7 · Cited by 306

The adult oligodendrocyte can participate in remyelination

Duncan, I. D., Radcliff, A. B., Heidari, M., Kidd, G., August, B. K., & Wierenga, L. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808064115 · Cited by 259

Relapsing and progressive forms of multiple sclerosis

Dutta, R., & Trapp, B. D. (2014) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000094 · Cited by 252

Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way

Zhang, M. A., Rego, D., Moshkova, M., Kébir, H., Chruscinski, A. J., Nguyen, H. T., Akkermann, R., Stanczyk, F. Z., Prat, A., Steinman, L., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118458109 · Cited by 216

The increasing incidence and prevalence of female multiple sclerosis—A critical analysis of potential environmental factors

Sellner, J., Kraus, J., Awad, A. M., Milo, R., Hemmer, B., & Stüve, O. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.02.006 · Cited by 208

Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach

Ortíz, G. G., Pacheco-Moisés, F. P., Bitzer-Quintero, O. K., Anguiano, A. C. R., Flores-Alvarado, L. J., Ramírez-Ramírez, V., Macías-Islas, M. Á., & Torres-Sánchez, E. D. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/708659 · Cited by 222

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. C. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 202

Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila

Liu, S., Rezende, R. M., Moreira, T. G., Tankou, S. K., Cox, L. M., Wu, M., Song, A., Dhang, F. H., Wei, Z., Costamagna, G., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.10.008 · Cited by 206

Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis

Cagol, A., Schaedelin, S. A., Baraković, M., Benkert, P., Todea, R., Rahmanzadeh, R., Galbusera, R., Lu, P., Weigel, M., Melie‐García, L., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.1025 · Cited by 187

Neurotoxicity of Nanomaterials: An Up-to-Date Overview

Teleanu, D. M., Chircov, C., Grumezescu, A. M., & Teleanu, R. I. (2019) · Nanomaterials · doi:10.3390/nano9010096 · Cited by 177

Neuropathology of mood disorders: Do we see the stigmata of inflammation?

Mechawar, N., & Savitz, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.212 · Cited by 165

Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients

Хайбуллин, Т. И., Ivanova, V. V., Martynova, E. V., Черепнев, Г. В., Хабиров, Ф. А., Granatov, E. V., Rizvanov, A. A., & Khaiboullina, S. F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00531 · Cited by 161

The central role of mitochondria in axonal degeneration in multiple sclerosis

Campbell, G. R., Worrall, J. T., & Mahad, D. (2014) · Multiple Sclerosis · doi:10.1177/1352458514544537 · Cited by 137

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing‐remitting multiple sclerosis

Novakova, L., Axelsson, M., Khademi, M., Zetterberg, H., Blennow, K., Malmeström, C., Piehl, F., Olsson, T. P., & Lycke, J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13881 · Cited by 147

Inherited and acquired disorders of myelin: The underlying myelin pathology

Duncan, I. D., & Radcliff, A. B. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.04.002 · Cited by 146

Therapeutic targets in the ASK1-dependent stress signaling pathways

Hayakawa, R., Hayakawa, T., Takeda, K., & Ichijo, H. (2012) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.88.434 · Cited by 146

The mechanism of action of glatiramer acetate in multiple sclerosis and beyond

Aharoni, R. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.09.005 · Cited by 123

Astrocytes in multiple sclerosis

Ludwin, S. K., Rao, V. T. S., Moore, C. S., & Antel, J. P. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516643396 · Cited by 131

n-3 Polyunsaturated fatty acids in animal models with neuroinflammation

Orr, S. K., Trépanier, M., & Bazinet, R. P. (2012) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2012.05.008 · Cited by 115

Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis

Huizinga, R., van der Star, B. J., Kipp, M., Jong, R., Gerritsen, W. H., Clarner, T., Puentes, F., Dijkstra, C. D., van der Valk, P., & Amor, S. (2011) · Glia · doi:10.1002/glia.22276 · Cited by 100

Molecular alterations of the blood–brain barrier under inflammatory conditions: The role of endothelial to mesenchymal transition

Troletti, C. D., de Goede, P., Kamermans, A., & de Vries, H. E. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.010 · Cited by 99

Drug targeting systems for inflammatory disease: One for all, all for one

Crielaard, B. J., Lammers, T., Schiffelers, R. M., & Storm, G. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.014 · Cited by 101

Central nervous system inflammation in disease related conditions: Mechanistic prospects

Fung, A., Vizcaychipi, M. P., Lloyd, D. G., Wan, Y., & Ma, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.061 · Cited by 95

Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T‐cell subsets in multiple sclerosis patients

Sacramento, P. M., Monteiro, C., Dias, A., Kasahara, T. M., Ferreira, T. B., Hygino, J., Wing, A. C., de Andrade, R. M., Rueda, F., Sales, M. C., et al. (2018) · European Journal of Immunology · doi:10.1002/eji.201847525 · Cited by 92

Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis

Zaguia, F., Saikali, P., Ludwin, S. K., Newcombe, J., Beauseigle, D., McCrea, E., Duquette, P., Prat, A., Antel, J. P., & Arbour, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202725 · Cited by 93

Identification and Quantification of Oligodendrocyte Precursor Cells in Multiple System Atrophy, Progressive Supranuclear Palsy and P arkinson's Disease

Ahmed, Z., Asi, Y. T., Lees, A. J., Révész, T., & Holton, J. L. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00637.x · Cited by 96

Metabolic response to epigallocatechin-3-gallate in relapsing-remitting multiple sclerosis: a randomized clinical trial

Mähler, A., Steiniger, J., Bock, M., Klug, L., Parreidt, N., Lorenz, M., Zimmermann, B. F., Krannich, A., Paul, F., & Boschmann, M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.075309 · Cited by 86

Pathological differences between white and grey matter multiple sclerosis lesions

Prins, M., Schul, E., Geurts, J. J. G., van der Valk, P., Drukarch, B., & van Dam, A. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12841 · Cited by 89

A possible role for inflammation in mediating apoptosis of oligodendrocytes as induced by the Lyme disease spirochete Borrelia burgdorferi

Ramesh, G., Benge, S., Pahar, B., & Philipp, M. T. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-72 · Cited by 80

Glial and axonal changes in systemic lupus erythematosus measured with diffusion of intracellular metabolites

Ercan, E., Magro‐Checa, C., Valabrègue, R., Branzoli, F., Wood, E. T., Steup‐Beekman, G. M., WEBB, A. G., Huizinga, T. W. J., van Buchem, M. A., & Ronen, I. (2016) · Brain · doi:10.1093/brain/aww031 · Cited by 83

The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6)

Bayani, J., & Diamandis, E. P. (2011) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.750 · Cited by 81

Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB1 receptor-mediated anti-inflammatory effects

de Lago, E., Moreno‐Martet, M., Cabranes, A., Ramos, J. A., & Fernández‐Ruíz, J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.030 · Cited by 76

Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis

Morris, G., Reiche, E. M. V., Murru, A., Carvalho, A. F., Maes, M. H. J., Berk, M., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0843-5 · Cited by 75

The Interaction between Viral and Environmental Risk Factors in the Pathogenesis of Multiple Sclerosis

Tarlinton, R. E., Хайбуллин, Т. И., Granatov, E. V., Martynova, E. V., Rizvanov, A. A., & Khaiboullina, S. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020303 · Cited by 76

Mechanism of experimental autoimmune encephalomyelitis in Lewis rats: recent insights from macrophages

Shin, T., Ahn, M., & Matsumoto, Y. (2012) · Anatomy & Cell Biology · doi:10.5115/acb.2012.45.3.141 · Cited by 71

The link of inflammation and neurodegeneration in progressive multiple sclerosis

Pérez‐Cerdá, F., Sánchez‐Gómez, M. V., & Matute, C. (2016) · Multiple Sclerosis and Demyelinating Disorders · doi:10.1186/s40893-016-0012-0 · Cited by 68

Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

Carvalho, F. B., Gutierres, J. M., Bohnert, C., Zago, A. M., Abdalla, F. H., Vieira, J. M., Palma, H. E., Oliveira, S. M., Spanevello, R. M., Duarte, M. M. M. F., et al. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.006 · Cited by 68

Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis

Schampel, A., Volovitch, O., Koeniger, T., Scholz, C. J., Haase, S., Linker, R. A., Wischmeyer, E., Wunsch, M., Hell, J. W., Ergün, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620052114 · Cited by 70

Molecular biomarkers in cerebrospinal fluid of multiple sclerosis patients

Fitzner, B., Hecker, M., & Zettl, U. K. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.06.001 · Cited by 69

The Blood-Brain Barrier in Multiple Sclerosis: microRNAs as Key Regulators

Kamphuis, W. W., Troletti, C. D., Reijerkerk, A., Romero, I. A., & de Vries, H. E. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150116125246 · Cited by 65

α-1-Antitrypsin Gene Delivery Reduces Inflammation, Increases T-Regulatory Cell Population Size and Prevents Islet Allograft Rejection

Shahaf, G., Moser, H., Ozeri, E., Mizrahi, M., Abecassis, A., & Lewis, E. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00145 · Cited by 70

The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized clinical trial

Asghari, K. M., Dolatkhah, N., Ayromlou, H., Mirnasiri, F., Dadfar, T., & Hashemian, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-46047-6 · Cited by 67

Drug Repurposing: A Systematic Approach to Evaluate Candidate Oral Neuroprotective Interventions for Secondary Progressive Multiple Sclerosis

Vesterinen, H. M., Connick, P., Irvine, C., Sena, E. S., Egan, K. J., Carmichael, G. G., Tariq, A., Pavitt, S. H., Chataway, J., Macleod, M. R., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117705 · Cited by 63

Cell therapy for multiple sclerosis: an evolving concept with implications for other neurodegenerative diseases

Rice, C. M., Kemp, K. C., Wilkins, A., & Scolding, N. J. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61810-3 · Cited by 65

Estrogen plays an important role by influencing the NLRP3 inflammasome

Dong, W., Peng, Q., Liu, Z., Xie, Z., Guo, X., Li, Y., & Chen, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115554 · Cited by 68

Trojan Horse Nanocapsule Enabled In Situ Modulation of the Phenotypic Conversion of Th17 Cells to Treg Cells for the Treatment of Multiple Sclerosis in Mice

Shi, C., Zhang, J., Wang, H., Chen, C., Han, M., Gao, L., Tang, C., Sun, P., Zhao, X., Guo, F., et al. (2022) · Advanced Materials · doi:10.1002/adma.202210262 · Cited by 60

The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia

Ramesh, G., Santana-Gould, L., Inglis, F. M., England, J. D., & Philipp, M. T. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-88 · Cited by 60

Infection Risk in Patients on Multiple Sclerosis Therapeutics

Williamson, E. M. L., & Berger, J. R. (2015) · CNS Drugs · doi:10.1007/s40263-015-0226-2 · Cited by 60

Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage

van den Bosch, A., Fransen, N., Mason, M., Rozemuller, A. J., Teunissen, C., Smolders, J., & Huitinga, I. (2022) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001154 · Cited by 58

Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J. K. H., Hsiao, C.-C., Mizee, M. R., Adelia, Vincenten, M. C. J., Kunkel, D., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01010-8 · Cited by 58

Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART): a multiarm phase IIb randomised, double-blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis

Connick, P., Angelis, F. D., Parker, R. A., Plantone, D., Doshi, A., John, N. A., Stutters, J., MacManus, D. G., Prados, F., Barkhof, F., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-021944 · Cited by 56

The executioners sing a new song: killer caspases activate microglia

Venero, J. L., Burguillos, M. Á., Brundin, P., & Joseph, B. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.107 · Cited by 55

Abnormal morphology of myelin and axon pathology in murine models of multiple sclerosis

Bandô, Y., Nomura, T., Bochimoto, H., Murakami, K., Tanaka, T., Watanabe, T., & Yoshida, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.01.002 · Cited by 51

Epstein–Barr virus and multiple sclerosis: Updating Pender's hypothesis

Laurence, M., & Benito‐León, J. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.05.009 · Cited by 53

Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model

Wilmes, A. T., Reinehr, S., Kühn, S., Pedreiturria, X., Petrikowski, L., Faissner, S., Ayzenberg, I., Stute, G., Gold, R., Dick, H. B., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1208-3 · Cited by 54

Role of glial cells in innate immunity and their role in CNS demyelination

Sriram, S. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.08.012 · Cited by 52

In vivo conversion of astrocytes to myelinating cells by miR-302/367 and valproate to enhance myelin repair

Ghasemi‐Kasman, M., Zare, L., Baharvand, H., & Javan, M. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2276 · Cited by 51

Innate immune responses in central nervous system inflammation

Finsen, B., & Owens, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.030 · Cited by 50

The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer

Stoka, V., Vasiljeva, O. S., Nakanishi, H., & Türk, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115613 · Cited by 53

The Detection of Surfactant Proteins A, B, C and D in the Human Brain and Their Regulation in Cerebral Infarction, Autoimmune Conditions and Infections of the CNS

Schob, S., Schicht, M., Sel, S., Stiller, D., Kekulé, A. S., Paulsen, F. P., Maronde, E., & Bräuer, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074412 · Cited by 50

Fasudil Ameliorates Disease Progression in Experimental Autoimmune Encephalomyelitis, Acting Possibly Through Antiinflammatory Effect

Hou, S., Liu, C., Li, Y., Yu, J., Feng, L., Liu, Y., Guo, M., Xie, Y., Meng, J., Zhang, H., et al. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12002 · Cited by 48

IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination

Zimmermann, J., Emrich, M., Krauthausen, M., Saxe, S., Nitsch, L., Heneka, M. T., Campbell, I. L., & Müller, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0368-3 · Cited by 52

A Systematic Review of Discrete-Choice Experiments and Conjoint Analysis Studies in People with Multiple Sclerosis

Webb, E., Meads, D. M., Eskytė, I., King, N. V., Dracup, N., Chataway, J., Ford, H. L., Marti, J., Pavitt, S. H., Schmierer, K., et al. (2018) · Patient · doi:10.1007/s40271-017-0296-y · Cited by 49

Hyperforin-loaded gold nanoparticle alleviates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells

Nosratabadi, R., Rastin, M., Sankian, M., Haghmorad, D., & Mahmoudi, M. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.04.001 · Cited by 48

Central nervous system targeted autoimmunity causes regional atrophy: a 9.4T MRI study of the EAE mouse model of Multiple Sclerosis

Hamilton, A. M., Forkert, N., Yang, R.-Z., Wu, Y., Rogers, J. A., Yong, W. V., & Dunn, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-44682-6 · Cited by 42

Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study

Senanayake, V. K., Jin, W., Mochizuki, A., Chitou, B., & Goodenowe, D. B. (2015) · BMC Neurology · doi:10.1186/s12883-015-0411-4 · Cited by 47

Primary Progressive Multiple Sclerosis: Putting Together the Puzzle

Abdelhak, A., Weber, M. S., & Tumani, H. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00234 · Cited by 46

Immunohistochemical detection of sphingosine‐1‐phosphate receptor 1 and 5 in human multiple sclerosis lesions

Brana, C., Frossard, M., Gobert, R. P., Martinier, N., Boschert, U., & Seabrook, T. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12048 · Cited by 45

Immune Modulation in the Treatment of Amyotrophic Lateral Sclerosis: A Review of Clinical Trials

Khalid, S. I., Ampie, L., Kelly, R. M., Ladha, S. S., & Dardis, C. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00486 · Cited by 46

The Role of Fungi in the Etiology of Multiple Sclerosis

Benito‐León, J., & Laurence, M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00535 · Cited by 45

Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice

Zhu, D., Liu, M., Yang, Y., Ma, L., Jiang, Y., Zhou, L., Huang, Q., Pi, R., & Chen, X. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23397 · Cited by 43

Enhanced Fluorine-19 MRI Sensitivity using a Cryogenic Radiofrequency Probe: Technical Developments and Ex Vivo Demonstration in a Mouse Model of Neuroinflammation

Waiczies, S., Millward, J. M., Starke, L., Delgado, P. R., Huelnhagen, T., Prinz, C., Marek, D., Wecker, D., Wissmann, R., Koch, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09622-2 · Cited by 43

Nr4a1 plays a crucial modulatory role in Th1/Th17 cell responses and CNS autoimmunity

Wang, L., Zhang, Y., Li, X., Zhang, M., Zhu, L. D., Zhang, G., & Xu, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.015 · Cited by 42

The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis

de Jong, C. G. H. M., Gabius, H., & Baron, W. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03327-7 · Cited by 44

Chronic experimental autoimmune encephalomyelitis is an excellent model to study neuroaxonal degeneration in multiple sclerosis

Voskuhl, R. R., & MacKenzie‐Graham, A. J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1024058 · Cited by 45

Cerebrospinal fluid complement system biomarkers in demyelinating disease

Zelek, W. M., Fathalla, D., Morgan, A. R., Touchard, S., Loveless, S., Tallantyre, E. C., Robertson, N. P., & Morgan, B. P. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458519887905 · Cited by 41

Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis

Kan, Q., Zhang, H.-J., Zhang, Y., Li, X., Xu, Y., Thomé, R., Zhang, M., Liu, N., Chu, Y., Zhang, G., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0333-1 · Cited by 41

Natalizumab reduces relapse clinical severity and improves relapse recovery in MS

LUBLIN, F. D., Cutter, G., Giovannoni, G., Pace, A., Campbell, N., & Belachew, S. M. (2014) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2014.08.005 · Cited by 41

Whole-Brain Propagation Delays in Multiple Sclerosis, a Combined Tractography-Magnetoencephalography Study

Sorrentino, P., Petkoski, S., Sparaco, M., Lopez, E. T., Signoriello, E., Baselice, F., Bonavita, S., Pirozzi, M. A., Quarantelli, M., Sorrentino, G., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0938-22.2022 · Cited by 40

SIRT1 and NAD + precursors: Therapeutic targets in multiple sclerosis a review

Nimmagadda, V. K. C., Makar, T. K., Chandrasekaran, K., Sagi, A. R., Ray, J., Russell, J. W., & Bever, C. T. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.07.007 · Cited by 39

Triiodothyronine Administration Ameliorates the Demyelination/Remyelination Ratio in a Non-Human Primate Model of Multiple Sclerosis by Correcting Tissue Hypothyroidism

D’Intino, G., Lorenzini, L., Fernández, M., Taglioni, A., Perretta, G., Vecchio, G. D., Villoslada, P., Giardino, L., & Calzà, L. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02181.x · Cited by 38

Ongoing Oxidative Stress Causes Subclinical Neuronal Dysfunction in the Recovery Phase of EAE

Radbruch, H., Bremer, D., Guenther, R., Cseresnyés, Z., Lindquist, R. L., Hauser, A. E., & Niesner, R. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00092 · Cited by 36

Signaling through the S1P−S1PR Axis in the Gut, the Immune and the Central Nervous System in Multiple Sclerosis: Implication for Pathogenesis and Treatment

Chatzikonstantinou, S., Poulidou, V., Arnaoutoglou, M., Kazis, D. A., Heliopoulos, I., Grigoriadis, N., & Boziki, M. K. (2021) · Cells · doi:10.3390/cells10113217 · Cited by 35

Multiple Sclerosis: Focus on Extracellular and Artificial Vesicles, Nanoparticles as Potential Therapeutic Approaches

Nuzzo, D., & Picone, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168866 · Cited by 36

MALDI imaging mass spectrometry analysis—A new approach for protein mapping in multiple sclerosis brain lesions

Maccarrone, G., Nischwitz, S., Deininger, S., Hornung, J., König, F. B., Stadelmann, C., Turck, C. W., & Weber, F. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.07.001 · Cited by 34

Main Role of Antibodies in Demyelination and Axonal Damage in Multiple Sclerosis

Muñoz, Ú., Sebal, C., Escudero, E., Esiri, M. M., Tzartos, J. S., Sloan, C., & Sádaba, M. C. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01059-6 · Cited by 33

Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

Bellavista, E., Santoro, A., Galimberti, D., Comi, C., Luciani, F., & Mishto, M. (2014) · Autoimmune Diseases · doi:10.1155/2014/739705 · Cited by 33

Diagnosis and Management of Secondary-Progressive Multiple Sclerosis: Time for Change

Oh, J., Alikhani, K., Bruno, T. R., Devonshire, V. A., Giacomini, P. S., Giuliani, F., Nakhai-Pour, H. R., Schecter, R., & Larochelle, C. (2019) · Neurodegenerative Disease Management · doi:10.2217/nmt-2019-0024 · Cited by 33

Mechanism of demyelination and remyelination in multiple sclerosis

Bandô, Y. (2020) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12576 · Cited by 36

Novel Therapeutic Targets in Neuroinflammation and Neuropathic Pain

Ramesh, G. (2014) · Inflammation and Cell Signaling · doi:10.14800/ics.111 · Cited by 33

Pharmacogenetics of multiple sclerosis

Tsareva, E., Кулакова, О. Г., Boyко, A., & Favorova, O. O. (2015) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000194 · Cited by 31

Optical coherence tomography (OCT) measurements and cognitive performance in multiple sclerosis: a systematic review and meta-analysis

Mirmosayyeb, O., Zivadinov, R., Weinstock‐Guttman, B., Benedict, R. H. B., & Jakimovski, D. (2022) · Journal of Neurology · doi:10.1007/s00415-022-11449-5 · Cited by 35

Multiple sclerosis

Kiran, G. U., Priya, T. S., Kumari, P. K., Pradeepa, S. G. S., & Lavanya, S. (2024) · GSC Biological and Pharmaceutical Sciences · doi:10.30574/gscbps.2024.26.2.0378

Multiple Sclerosis Pathology

Lassmann, H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a028936 · Cited by 937

What drives disease in multiple sclerosis: Inflammation or neurodegeneration?

Lassmann, H. (2010) · Clinical and Experimental Neuroimmunology · doi:10.1111/j.1759-1961.2009.00003.x · Cited by 50

Inflammation and degeneration in multiple sclerosis

Brück, W., & Stadelmann, C. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0170-7 · Cited by 130

The relation between inflammation and neurodegeneration in multiple sclerosis brains

Frischer, J. M., Bramow, S., Dal-Bianco, A., Lucchinetti, C. F., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., & Lassmann, H. (2009) · Brain · doi:10.1093/brain/awp070 · Cited by 1,450