Cited by 276Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsPsoriasis: Treatment and Pathogenesis

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Inflammation, demyelination, and degeneration — Recent insights from MS pathology

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Stadelmann, Christine, Wegner, Christiane, Brück, Wolfgang·2011·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2010.07.007

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Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which responds to anti-inflammatory treatments in the early disease phase. However, the pathogenesis of the progressive disease phase is less well understood, and inflammatory as well as neurodegenerative mechanisms of tissue damage are currently being discussed. This review summarizes current knowledge on the interrelation between inflammation, demyelination, and neurodegeneration derived from the study of human autopsy and biopsy brain tissue and experimental models of MS.

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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
Lennon, V. A., Kryzer, T. J., Pittock, S. J., Verkman, A. S., & Hinson, S. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050304 · Cited by 2,288
The spectrum of neuromyelitis optica
Wingerchuk, D. M., Lennon, V. A., Lucchinetti, C. F., Pittock, S. J., & Weinshenker, B. G. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70216-8 · Cited by 2,182
Cortical demyelination and diffuse white matter injury in multiple sclerosis
Kutzelnigg, A., Lucchinetti, C. F., Stadelmann, C., Brück, W., Rauschka, H., Bergmann, M., Schmidbauer, M., Parisi, J. E., & Lassmann, H. (2005) · Brain · doi:10.1093/brain/awh641 · Cited by 1,836
Self-citation
Multiple sclerosis--the plaque and its pathogenesis.
Frohman, E., Racke, M., & Raine, C. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052130 · Cited by 1,793
Axonal damage in acute multiple sclerosis lesions
Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology
Magliozzi, R., Howell, O. W., Vora, A., Serafini, B., Nicholas, R. S., Puopolo, M., Reynolds, R., & Aloisi, F. (2006) · Brain · doi:10.1093/brain/awm038 · Cited by 1,486
The relation between inflammation and neurodegeneration in multiple sclerosis brains
Frischer, J. M., Bramow, S., Dal-Bianco, A., Lucchinetti, C. F., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., & Lassmann, H. (2009) · Brain · doi:10.1093/brain/awp070 · Cited by 1,450
Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
Peterson, J. W., Bö, L., Mörk, S., Chang, A., & Trapp, B. D. (2001) · Annals of Neurology · doi:10.1002/ana.1123 · Cited by 1,403
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.
Lucchinetti, C., Mandler, R., McGavern, D., Brück, W., Gleich, G., Ransohoff, R., Trebst, C., Weinshenker, B., Wingerchuk, D., Parisi, J., et al. (2002) · Brain : a journal of neurology · doi:10.1093/brain/awf151 · Cited by 1,228
Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
Barnett, M. H., & Prineas, J. W. (2004) · Annals of Neurology · doi:10.1002/ana.20016 · Cited by 1,184
Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis
The CAMMS Trial Investigators (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802670 · Cited by 1,021
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
Gold, R. (2006) · Brain · doi:10.1093/brain/awl075 · Cited by 1,017
Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process
Confavreux, C. (2003) · Brain · doi:10.1093/brain/awg081 · Cited by 1,017
Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation
Bitsch, A. (2000) · Brain · doi:10.1093/brain/123.6.1174 · Cited by 898
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
Dutta, R., McDonough, J., Yin, X., Peterson, J. W., Chang, A., Torres, T., Gudz, T. I., Macklin, W. B., Lewis, D., Fox, R., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20736 · Cited by 881
Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864
Self-citation
Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time.
Kuhlmann, T., Lingfeld, G., Bitsch, A., Schuchardt, J., & Brück, W. (2002) · Brain : a journal of neurology · doi:10.1093/brain/awf235 · Cited by 851
Remyelination is extensive in a subset of multiple sclerosis patients
Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807
Self-citation
Subpial Demyelination in the Cerebral Cortex of Multiple Sclerosis Patients
Bø, L., Vedeler, C. A., Nyland, H. I., Trapp, B. D., & Mørk, S. J. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.7.723 · Cited by 757
Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis
Roemer, S. F., Parisi, J. E., Lennon, V. A., Benarroch, E. E., Lassmann, H., Brück, W., Mandler, R. N., Weinshenker, B. G., Pittock, S. J., Wingerchuk, D. M., et al. (2007) · Brain · doi:10.1093/brain/awl371 · Cited by 716
Self-citation
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 664
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis
Trapp, B. D., & Stys, P. K. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70043-2 · Cited by 621
Intrathecal pathogenic anti–aquaporin‐4 antibodies in early neuromyelitis optica
Bennett, J. L., Lam, C., Kalluri, S. R., Saikali, P., Bautista, K., Dupree, C., Glogowska, M. J., Case, D., Antel, J. P., Owens, G. P., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21802 · Cited by 593
Self-citation
Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo
Bradl, M., Misu, T., Takahashi, T., Watanabe, M., Mader, S., Reindl, M., Adzemovic, M. Z., Bauer, J., Berger, T., Fujihara, K., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21837 · Cited by 582
Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions
Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R., & Cho, E. ‐. (1993) · Annals of Neurology · doi:10.1002/ana.410330203 · Cited by 574
β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury
Gentleman, S. M., Nash, M. J., Sweeting, C. J., Graham, D. I., & Roberts, G. W. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90398-5 · Cited by 570
The role of nitric oxide in multiple sclerosis
Smith, K. J., & Lassmann, H. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00102-3 · Cited by 535
Monocyte/macrophage differentiation in early multiple sclerosis lesions
Brück, W., Porada, P., Poser, S., Rieckmann, P., Hanefeld, F., Kretzschmarch, H. A., & Lassmann, H. (1995) · Annals of Neurology · doi:10.1002/ana.410380514 · Cited by 521
Self-citation
Evidence of Axonal Damage in the Early Stages of Multiple Sclerosis and Its Relevance to Disability
Stefano, N. D., Narayanan, S., Francis, G., Arnaoutelis, R., Tartaglia, M. C., Antel, J. P., Matthews, P. M., & Arnold, D. L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.1.65 · Cited by 505
Thalamic neurodegeneration in multiple sclerosis
Cifelli, A., Arridge, M., Jezzard, P., Esiri, M., Palace, J. A., & Matthews, P. (2002) · Annals of Neurology · doi:10.1002/ana.10326 · Cited by 500
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
Lucchinetti, C. F., Gavrilova, R. H., Metz, I., Parisi, J. E., Scheithauer, B. W., Weigand, S., Thomsen, K., Mandrekar, J., Altintas, A., Erickson, B. J., et al. (2008) · Brain · doi:10.1093/brain/awn098 · Cited by 493
Self-citation
Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration
Bø, L., Vedeler, C. A., Nyland, H., Trapp, B. D., & Mørk, S. J. (2003) · Multiple Sclerosis Journal · doi:10.1191/1352458503ms917oa · Cited by 478
Autoimmune encephalomyelitis ameliorated by AMPA antagonists
Smith, T., Groom, A., Zhu, B., & Turski, L. (2000) · Nature Medicine · doi:10.1038/71548 · Cited by 467
A quantitative analysis of oligodendrocytes in multiple sclerosis lesions
Lucchinetti, C., Brück, W., Parisi, J., Scheithauer, B., Rodriguez, M., & Lassmann, H. (1999) · Brain · doi:10.1093/brain/122.12.2279 · Cited by 464
Self-citation
Mitochondrial changes within axons in multiple sclerosis
Mahad, D. J., Ziabreva, I., Campbell, G., Lax, N., White, K., Hanson, P. S., Lassmann, H., & Turnbull, D. M. (2009) · Brain · doi:10.1093/brain/awp046 · Cited by 454
Immunopathology of secondary‐progressive multiple sclerosis
Prineas, J. W., Kwon, E. E., Cho, E., Sharer, L. R., Barnett, M. H., Oleszak, E. L., Hoffman, B. E., & Morgan, B. P. (2001) · Annals of Neurology · doi:10.1002/ana.1255 · Cited by 453
Neocortical neuronal, synaptic, and glial loss in multiple sclerosis
Wegner, C., Esiri, M. M., Chance, S. A., Palace, J. A., & Matthews, P. M. (2006) · Neurology · doi:10.1212/01.wnl.0000237551.26858.39 · Cited by 441
Self-citation
Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange
Keegan, M., König, F. B., McClelland, R. L., Brück, W., Morales, Y., Bitsch, A., PANITCH, H. S., Lassmann, H., Weinshenker, B. G., Rodriguez, M., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67102-4 · Cited by 432
Self-citation
Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
O’Connor, K. C., McLaughlin, K. A., Jager, P. L. D., Chitnis, T., Bettelli, E., Xu, C., Robinson, W. H., Cherry, S. V., Bar‐Or, A., Banwell, B., et al. (2007) · Nature Medicine · doi:10.1038/nm1488 · Cited by 419
Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis
Evangelou, N. (2000) · Brain · doi:10.1093/brain/123.9.1845 · Cited by 416
Pathogenesis of axonal and neuronal damage in multiple sclerosis
Dutta, R., & Trapp, B. D. (2007) · Neurology · doi:10.1212/01.wnl.0000275229.13012.32 · Cited by 411
Remyelination capacity of the MS brain decreases with disease chronicity
Goldschmidt, T., Antel, J., König, F. B., Brück, W., & Kuhlmann, T. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a8260a · Cited by 411
Self-citation
Patterns of oligodendroglia pathology in multiple sclerosis
Ozawa, K., Suchanek, G., Breitschopf, H., Br€ck, W., Budka, H., Jellinger, K. A., & Lassmann, H. (1994) · Brain · doi:10.1093/brain/117.6.1311 · Cited by 404
Self-citation
Multiple sclerosis: Distribution of inflammatory cells in newly forming lesions
Henderson, A. P. D., Barnett, M. H., Parratt, J. D. E., & Prineas, J. W. (2009) · Annals of Neurology · doi:10.1002/ana.21800 · Cited by 403
Neurofascin as a novel target for autoantibody-mediated axonal injury
Mathey, E. K., Derfuss, T. J., Storch, M. K., Williams, K. R., Hales, K., Woolley, D., Al‐Hayani, A., Davies, S. N., Rasband, M. N., Olsson, T. P., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071053 · Cited by 389
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357
Axonal changes in chronic demyelinated cervical spinal cord plaques
Lovas, G., Szilágyi, N., Majtényi, K., Palkovits, M., & Komoly, S. (2000) · Brain · doi:10.1093/brain/123.2.308 · Cited by 356
Homogeneity of active demyelinating lesions in established multiple sclerosis
Breij, E. C. W., Brink, B. P., Veerhuis, R., van den Berg, C., Vloet, R. P. M., Yan, R., Dijkstra, C. D., van der Valk, P., & Bø, L. (2008) · Annals of Neurology · doi:10.1002/ana.21311 · Cited by 353
A longitudinal study of brain atrophy in relapsing multiple sclerosis
Simon, J. H., Jacobs, L., Campion, M., Rudick, R. A., Cookfair, D. L., Herndon, R. M., Richert, J. R., Salazar, A. Μ., Fischer, J. S., Goodkin, D. E., et al. (1999) · Neurology · doi:10.1212/wnl.53.1.139 · Cited by 337
Antibodies to native myelin oligodendrocyte glycoprotein in children with inflammatory demyelinating central nervous system disease
Brilot, F., Dale, R. C., Selter, R., Grummel, V., Kalluri, S. R., Aslam, M., Busch, V., Zhou, D., Cepok, S., & Hemmer, B. (2009) · Annals of Neurology · doi:10.1002/ana.21916 · Cited by 324
Extensive cortical remyelination in patients with chronic multiple sclerosis
Albert, M., Antel, J., Brück, W., & Stadelmann, C. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00043.x · Cited by 314
Self-citation
Grey Matter Pathology in Multiple Sclerosis
Vercellino, M., Plano, F., Votta, B., Mutani, R., Giordana, M. T., & Cavalla, P. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000190067.20935.42 · Cited by 297
Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study
Burt, R. K., Loh, Y., Cohen, B. A., Stefoski, D., Balabanov, R. D., Katsamakis, G., Oyama, Y., Russell, E. J., Stern, J. L., Muraro, P. A., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70017-1 · Cited by 285
Demyelination, Inflammation, and Neurodegeneration in Multiple Sclerosis Deep Gray Matter
Vercellino, M., Masera, S., Lorenzatti, M., Condello, C., Merola, A., Mattioda, A., Tribolo, A., Capello, E., Mancardi, G., Mutani, R., et al. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a19a5a · Cited by 283
Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord
Wolswijk, G. (2002) · Brain · doi:10.1093/brain/awf031 · Cited by 268
Axonal loss in multiple sclerosis: a pathological survey of the corticospinal and sensory tracts
DeLuca, G. C. (2004) · Brain · doi:10.1093/brain/awh118 · Cited by 255
Blockers of sodium and calcium entry protect axons from nitric oxide‐mediated degeneration
Kapoor, R., Davies, M., Blaker, P. A., Hall, S. M., & Smith, K. J. (2002) · Annals of Neurology · doi:10.1002/ana.10443 · Cited by 252
Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis
Quintana, F. J., Farez, M., Viglietta, V., Iglesias, A. H., Merbl, Y., Izquierdo, G., Lucas, M., Basso, A. S., Khoury, S. J., Lucchinetti, C. F., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806310105 · Cited by 243
Accumulation of cortical lesions in MS: relation with cognitive impairment
Roosendaal, S. D., Moraal, B., Pouwels, P. J. W., Vrenken, H., Castelijns, J. A., Barkhof, F., & Geurts, J. J. G. (2009) · Multiple Sclerosis Journal · doi:10.1177/1352458509102907 · Cited by 243
The effect of interferon beta-1b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
Molyneux, P. D., Kappos, L., Polman, C. H., Pozzilli, C., Barkhof, F., Filippi, M., Yousry, T. A., Hahn, D. W., Wagner, K., Ghazi, M. K. K., et al. (2000) · Brain · doi:10.1093/brain/123.11.2256 · Cited by 241
Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals
Derfuss, T. J., Parikh, K., Velhin, S., Braun, M., Mathey, E. K., Krumbholz, M., Kümpfel, T., Moldenhauer, A., Rader, C. M., Sonderegger, P., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901496106 · Cited by 226
A new focal EAE model of cortical demyelination: Multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination
Merkler, D. (2006) · Brain · doi:10.1093/brain/awl135 · Cited by 222
Substantial Archaeocortical Atrophy and Neuronal Loss in Multiple Sclerosis
Papadopoulos, D., Dukes, S., Patel, R., Nicholas, R., Vora, A., & Reynolds, R. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00177.x · Cited by 192
The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions
Brink, B. P., Veerhuis, R., Breij, E. C. W., van der Valk, P., Dijkstra, C. D., & Bö, L. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.147 · Cited by 191
Altered Glutamate Reuptake in Relapsing-Remitting and Secondary Progressive Multiple Sclerosis Cortex: Correlation With Microglia Infiltration, Demyelination, and Neuronal and Synaptic Damage
Vercellino, M., Merola, A., Piacentino, C., Votta, B., Capello, E., Mancardi, G. L., Mutani, R., Giordana, M. T., & Cavalla, P. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31812571b0 · Cited by 190
Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE
Ziehn, M. O., Avedisian, A., Tiwari-Woodruff, S., & Voskuhl, R. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.6 · Cited by 190
The blood-brain barrier in cortical multiple sclerosis lesions
van Horssen, J., Brink, B. P., de Vries, H. E., van der Valk, P., & Bø, L. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318040b2de · Cited by 187
Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis
Young, N. P., Weinshenker, B. G., Parisi, J. E., Scheithauer, B. W., Giannini, C., Roemer, S. F., Thomsen, K. M., Mandrekar, J. N., Erickson, B. J., & Lucchinetti, C. F. (2010) · Brain · doi:10.1093/brain/awp321 · Cited by 186
Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis
Tallantyre, E. C., Bø, L., Alrawashdeh, O., Owens, T., Polman, C. H., Lowe, J. S., & Evangelou, N. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510364992 · Cited by 180
Axonal and neuronal pathology in multiple sclerosis: What have we learnt from animal models
Lassmann, H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.009 · Cited by 171
Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation
Stirling, D. P., & Stys, P. K. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.02.002 · Cited by 163
Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions
Mews, I., Bergmann, M., Bunkowski, S., Gullotta, F., & Brück, W. (1998) · Multiple Sclerosis Journal · doi:10.1177/135245859800400203 · Cited by 160
Self-citation
Pattern of T2 hypointensity associated with ring-enhancing brain lesions can help to differentiate pathology
Schwartz, K. M., Erickson, B. J., & Lucchinetti, C. F. (2006) · Neuroradiology · doi:10.1007/s00234-005-0024-5 · Cited by 159
Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis
Vogt, J., Paul, F., Aktas, O., Müller‐Wielsch, K., Dörr, J., Dörr, S., Bharathi, B. S., Glumm, R., Schmitz, C., Steinbusch, H., et al. (2009) · Annals of Neurology · doi:10.1002/ana.21719 · Cited by 157
Remodeling of Axonal Connections Contributes to Recovery in an Animal Model of Multiple Sclerosis
Kerschensteiner, M., Bareyre, F. M., Buddeberg, B. S., Merkler, D., Stadelmann, C., Brück, W., Misgeld, T., & Schwab, M. E. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040452 · Cited by 146
Self-citation
Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis
Anderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., et al. (2008) · Brain · doi:10.1093/brain/awn119 · Cited by 141
Persistent endothelial abnormalities and blood–brain barrier leak in primary and secondary progressive multiple sclerosis
Leech, S., Kirk, J., Plumb, J., & McQuaid, S. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00781.x · Cited by 137
Cortical lesions and brain atrophy in MS
Kutzelnigg, A., & Lassmann, H. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.027 · Cited by 135
Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis.
Metz, I., Lucchinetti, C., Openshaw, H., García-Merino, A., Lassmann, H., Freedman, M., Atkins, H., Azzarelli, B., Kolar, O., & Brück, W. (2007) · Brain : a journal of neurology · doi:10.1093/brain/awl370 · Cited by 135
Self-citation
The macrophage in MS: just a scavenger after all? Pathology and pathogenesis of the acute MS lesion
Barnett, M. H., Henderson, A. P. D., & Prineas, J. W. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1304rr · Cited by 134
Seven-Tesla Magnetic Resonance Imaging
Ge, Y., Zohrabian, V. M., & Grossman, R. I. (2008) · Archives of Neurology · doi:10.1001/archneur.65.6.812 · Cited by 125
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Moll, N. M., Rietsch, A. M., Ransohoff, A., Cossoy, M. B., Huang, D., Eichler, F., Trapp, B. D., & Ransohoff, R. M. (2007) · Neurology · doi:10.1212/01.wnl.0000284601.54436.e4 · Cited by 125
Extensive cortical inflammation is associated with epilepsy in multiple sclerosis
Calabrese, M., Stefano, N., Atzori, M., Bernardi, V., Mattisi, I., Barachino, L., Rinaldi, L., Morra, A., McAuliffe, M., Perini, P., et al. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0752-7 · Cited by 123
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Dal Bianco, A., Bradl, M., Frischer, J., Kutzelnigg, A., Jellinger, K., & Lassmann, H. (2008) · Annals of Neurology · doi:10.1002/ana.21240 · Cited by 123
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Kooi, E., Geurts, J. J. G., van Horssen, J., Bø, L., & van der Valk, P. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181b4bf8f · Cited by 115
Immune Cells Contribute to Myelin Degeneration and Axonopathic Changes in Mice Overexpressing Proteolipid Protein in Oligodendrocytes
Ip, C. W., Kroner, A., Bendszus, M., Leder, C., Kobsar, I., Fischer, S., Wiendl, H., Nave, K., & Martini, R. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1921-06.2006 · Cited by 109
Contribution of White Matter Lesions to Gray Matter Atrophy in Multiple Sclerosis
Sepulcre, J., Goñi, J., Masdeu, J. C., Bejarano, B., de Mendizábal, N. V., Toledo, J. B., & Villoslada, P. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.562 · Cited by 108
Progressive multiple sclerosis
Bradl, M., & Lassmann, H. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0182-3 · Cited by 108
Somatosensory cortical atrophy after spinal cord injury: A voxel-based morphometry study
Jurkiewicz, M. T., Crawley, A. P., Verrier, M. C., Fehlings, M. G., & Mikulis, D. J. (2006) · Neurology · doi:10.1212/01.wnl.0000201276.28141.40 · Cited by 103
Demyelinated neocortical lesions in marmoset autoimmune encephalomyelitis mimic those in multiple sclerosis
Pomeroy, I. M., Matthews, P. M., Frank, J. A., Jordan, E. K., & Esiri, M. M. (2005) · Brain · doi:10.1093/brain/awh626 · Cited by 102
Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice.
Bannerman, P., Hahn, A., Ramirez, S., Morley, M., Bonnemann, C., Yu, S., Zhang, G.-X., Rostami, A., & Pleasure, D. (2005) · Brain : a journal of neurology · doi:10.1093/brain/awh550 · Cited by 100
Spinal Cord Neuronal Pathology in Multiple Sclerosis
Gilmore, C. P., DeLuca, G., Bö, L., Owens, T., Lowe, J., Esiri, M., & Evangelou, N. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00228.x · Cited by 99
Lessons from multiple sclerosis: models, concepts, observations
Wekerle, H. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098020 · Cited by 96
Cortical Demyelination Can Be Modeled in Specific Rat Models of Autoimmune Encephalomyelitis and Is Major Histocompatability Complex (MHC) Haplotype-Related
Storch, M., Bauer, J., Linington, C., Olsson, T., Weissert, R., & Lassmann, H. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000248547.13176.9d · Cited by 90
Upregulation of Immunoglobulin‐related Genes in Cortical Sections from Multiple Sclerosis Patients
Torkildsen, Ø., Stansberg, C. T., Angelskår, S. M., Kooi, E., Geurts, J. J. G., van der Valk, P., Myhr, K., Steen, V. M., & Bø, L. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00343.x · Cited by 89
Activation of the ciliary neurotrophic factor (CNTF) signalling pathway in cortical neurons of multiple sclerosis patients
Dutta, R., McDonough, J. A., Chang, A., Swamy, L., Siu, A., Kidd, G. J., Rudick, R. A., Mirnics, K., & Trapp, B. D. (2007) · Brain · doi:10.1093/brain/awm206 · Cited by 87
Clinical course, pathological correlations, and outcome of biopsy proved inflammatory demyelinating disease
Pittock, S. J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.060624 · Cited by 81
New concepts on progressive multiple sclerosis
Lassmann, H. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0036-0 · Cited by 76
Hyperphosphorylation and Aggregation of Tau in Experimental Autoimmune Encephalomyelitis
Schneider, A., Araújo, G. W., Trajković, K., Herrmann, M. M., Merkler, D., Mandelkow, E., Weissert, R., & Simons, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409954200 · Cited by 72
Immunization With Neurofilament Light Protein Induces Spastic Paresis and Axonal Degeneration in Biozzi ABH Mice
Huizinga, R., Heijmans, N., Schubert, P., Gschmeissner, S., Hart, B. A. ‘., Herrmann, H. O., & Amor, S. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318040ad5c · Cited by 65
Axonal injury in the cerebral normal-appearing white matter of patients with multiple sclerosis is related to concurrent demyelination in lesions but not to concurrent demyelination in normal-appearing white matter
Narayanan, S., Francis, S. J., Sled, J. G., dos Santos, A. C., Antel, S. B., Levesque, I. R., Brass, S. D., Lapierre, Y., Sappey‐Marinier, D., Pike, G. B., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.017 · Cited by 62
Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase
Sajad, M., Zargan, J., Chawla, R., Umar, S., Sadaqat, M., & Khan, H. A. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0088-3 · Cited by 60
Substantial early, but nonprogressive neuronal loss in multiple sclerosis (ms) spinal cord
Schirmer, L., Albert, M., Buss, A., Schulz‐Schaeffer, W. J., Antel, J. P., Brück, W., & Stadelmann, C. (2009) · Annals of Neurology · doi:10.1002/ana.21799 · Cited by 56
Self-citation
Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in the common marmoset reflects the immunopathology of pattern II multiple sclerosis lesions
Merkler, D., Schmelting, B., Czéh, B., Fuchs, E., Stadelmann, C., & Brück, W. (2006) · Multiple Sclerosis Journal · doi:10.1191/1352458506ms1290oa · Cited by 54
Self-citation
Persistence of Immunopathological and Radiological Traits in Multiple Sclerosis
König, F. B., Wildemann, B., Nessler, S., Zhou, D., Hemmer, B., Metz, I., Hartung, H., Kieseier, B. C., & Brück, W. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1527 · Cited by 46
Self-citation
Autoantibodies and neurodegeneration in multiple sclerosis
Vyshkina, T., & Kálmán, B. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.53 · Cited by 44
Autoimmune Encephalomyelitis and Uveitis Induced by T Cell Immunity to Self β-Synuclein
Mor, F., Quintana, F. J., Mimran, A., & Cohen, I. R. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.628 · Cited by 40
Evidence for relative cortical sparing in benign multiple sclerosis: a longitudinal magnetic resonance imaging study
Calabrese, M., Filippi, M., Rovaris, M., Bernardi, V., Atzori, M., Mattisi, I., Favaretto, A., Grossi, P., Barachino, L., Rinaldi, L., et al. (2009) · Multiple Sclerosis · doi:10.1177/1352458508096686 · Cited by 38
Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte‐directed CD8+ T cell attack
Göbel, K., Melzer, N., Herrmann, A. M., Schuhmann, M. K., Bittner, S., Ip, C. W., Hünig, T., Meuth, S. G., & Wiendl, H. (2009) · Glia · doi:10.1002/glia.20938 · Cited by 34
Focal and diffuse cortical degenerative changes in a marmoset model of multiple sclerosis
Pomeroy, I. M., Jordan, E., Frank, J., Matthews, P. M., & Esiri, M. M. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458509360362 · Cited by 31
Gray matter pathology and multiple sclerosis
Wegner, C., & Stadelmann, C. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0058-x · Cited by 23
Self-citation
Clonal expansions of pathogenic CD8+ effector cells in the CNS of myelin mutant mice
Leder, C., Schwab, N., Ip, C. W., Kroner, A., Nave, K., Dornmair, K., Martini, R., & Wiendl, H. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.08.002 · Cited by 19
MS: is it one disease?
Esiri, M. M. (2009) · PubMed · Cited by 9
Multiple Sclerosis Pathology During Early and Late Disease Phases: Pathogenic and Clinical Relevance
Lucchinetti, C. F. (2007) · Springer eBooks · doi:10.1007/978-0-387-36003-4_12 · Cited by 7
Immune Regulation and Immunotherapy in Autoimmune Disease
Zhang., J. (2007) · Springer eBooks · doi:10.1007/978-0-387-36003-4 · Cited by 7
Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights substrates of disability
Sperfeld (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199911)46:5 · Cited by 2
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2
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Bridel, C., van Wieringen, W. N., Zetterberg, H., Tijms, B. M., Teunissen, C. E., and the NFL Group, Alvarez-Cermeño, J. C., Andreasson, U., Axelsson, M., Bäckström, D. C., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1534 · Cited by 764
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Riazifar, M., Mohammadi, M. R., Pone, E. J., Yeri, A., Lässer, C., Segaliny, A. I., McIntyre, L. L., Shelke, G. V., Hutchins, E., Hamamoto, A., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b01004 · Cited by 551
Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain
Ramesh, G., MacLean, A. G., & Philipp, M. T. (2013) · Mediators of Inflammation · doi:10.1155/2013/480739 · Cited by 639
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Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008762117 · Cited by 476
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Skripuletz, T., Hackstette, D., Bauer, K., Gudi, V., Pul, R., Voss, E., Berger, K., Kipp, M., Baumgärtner, W., & Stangel, M. (2013) · Brain · doi:10.1093/brain/aws262 · Cited by 376

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Authors: Stadelmann, C., Wegner, C., & Brück, W.
Affiliations: Universitätsmedizin Göttingen (DE)
Corresponding author: Stadelmann, Christine
ORCID: Stadelmann, Christine
Brück, Wolfgang
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2011-02
Volume: 1812
Issue: 2
Pages: 275-282
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2010.07.007
OpenAlex: W2108088418
Cited by: 276
References: 117
Citations by year: 2026: 10 · 2025: 8 · 2024: 16 · 2023: 13 · 2022: 26 · 2021: 14 · 2020: 17 · 2019: 27 · 2018: 19 · 2017: 22 · 2016: 22 · 2015: 17 · 2014: 14 · 2013: 22 · 2012: 16
FWCI: 1.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 898 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
GRO (submittedVersion, cc-by)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: multiple sclerosis, neuroinflammation, demyelination, neurodegeneration, progressive multiple sclerosis, central nervous system, autopsy brain tissue, pathogenesis
MeSH terms: Animals, Autoantigens, Axons, Demyelinating Diseases, Humans, Inflammation, Multiple Sclerosis, Nerve Degeneration, Neurons, Autoimmunity

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Inflammation, demyelination, and degeneration — Recent insights from MS pathology

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