Possible roles of DLK1 in the Notch pathway during development and disease
Open accessAbstract
The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function.
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The organization of the sinusoidal capillaries abuts HSECs against hepatic and mesenchymal lineages, which robustly express the Notch inhibitor Dlk1.
“In addition, the organization of the sinusoidal capillaries abuts HSECs against hepatic and mesenchymal lineages, which robustly express the Notch inhibitor Dlk1”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Falix et al., 2012
Section 3.3 (Liver development; page unavailable) reports abundant Dlk1 expression in embryonic mouse liver and identifies DLK1-positive fetal liver cells as hepatoblasts. The paper also describes DLK1 as an inhibitor of Notch signaling. It does not establish robust expression in both hepatic and mesenchymal lineages adjacent to HSECs, or describe the claimed sinusoidal-capillary arrangement. (LLM, conf=0.87)
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Research works printed but not linked: 6
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- Authors
- Falix, F. A., Aronson, D. C., Lamers, W. H., & Gaemers, I. C.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Gaemers, Ingrid C.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 1822
- Issue
- 6
- Pages
- 988-995
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W1979843262
- Cited by
- 191
- References
- 1
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 20 · 2023: 12 · 2022: 13 · 2021: 18 · 2020: 16 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 13 · 2014: 16 · 2013: 6 · 2012: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 412 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- DLK1, Notch signaling, Notch receptor, Notch ligands, developmental signaling, cell fate determination, terminal differentiation, Notch signaling inhibition
- MeSH terms
- Animals, Calcium-Binding Proteins, Cell Differentiation, Humans, Membrane Proteins, Neoplasms, Signal Transduction, Protein Structure, Secondary, Intercellular Signaling Peptides and Proteins, Embryonic Development, Intracellular Signaling Peptides and Proteins, Cell Proliferation, Mice, Receptors, Notch
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