Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity

Fast gapped-read alignment with Bowtie 2

Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400 · see citing works

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works

The mouse brain in stereotaxic coordinates

Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796 · see citing works

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859 · see citing works

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works

Nuclear receptor that identifies a novel retinoic acid response pathway

Mangelsdorf, D. J., Ong, E. S., Dyck, J. A., & Evans, R. M. (1990) · Nature · doi:10.1038/345224a0 · Cited by 1,491 · see citing works

Nuclear Receptors, RXR, and the Big Bang

Evans, R. M., & Mangelsdorf, D. J. (2014) · Cell · doi:10.1016/j.cell.2014.03.012 · Cited by 1,200 · see citing works

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.Preprint

Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A., & Evans, R. M. (1992) · Genes & Development · doi:10.1101/gad.6.3.329 · Cited by 1,193 · see citing works

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951 · see citing works

Overview of retinoid metabolism and function

Blomhoff, R., & Blomhoff, H. K. (2006) · Journal of Neurobiology · doi:10.1002/neu.20242 · Cited by 948 · see citing works

ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876 · see citing works

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., & Tontonoz, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.507 · Cited by 683 · see citing works

Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years

Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650 · see citing works

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

Gjoneska, E., Pfenning, A. R., Mathys, H., Quon, G., Kundaje, A., Tsai, L.-H., & Kellis, M. (2015) · Nature · doi:10.1038/nature14252 · Cited by 576 · see citing works

Contact-Dependent Inhibition of Cortical Neurite Growth Mediated by Notch Signaling

Šestan, N., Artavanis‐Tsakonas, S., & RAKIC, P. T. (1999) · Science · doi:10.1126/science.286.5440.741 · Cited by 571 · see citing works

Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1–42 levels in APPV717I transgenic mice

Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Hanke, A., Dewachter, I., Kuiperi, C., O'Banion, K., Klockgether, T., Van Leuven, F., & Landreth, G. E. (2005) · Brain · doi:10.1093/brain/awh452 · Cited by 565 · see citing works

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

Aguirre, A. A., Rubio, M. E., & Gallo, V. (2010) · Nature · doi:10.1038/nature09347 · Cited by 482 · see citing works

Differentiation of mouse embryonic stem cells into a defined neuronal lineage

Bibel, M., Richter, J., Schrenk, K., Tucker, K. L., Staiger, V., Korte, M., Goetz, M., & Barde, Y.-A. (2004) · Nature Neuroscience · doi:10.1038/nn1301 · Cited by 450 · see citing works

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

Jepsen, K., Solum, D., Zhou, T., McEvilly, R. J., Kim, H., Glass, C. K., Hermanson, O., & Rosenfeld, M. G. (2007) · Nature · doi:10.1038/nature06270 · Cited by 399 · see citing works

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

Chen, Y., Durakoglugil, M. S., Xian, X., & Herz, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914984107 · Cited by 368 · see citing works

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

Holtzman, D. M., Pitas, R. E., Kilbridge, J., Nathan, B., Mahley, R. W., Bu, G., & Schwartz, A. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9480 · Cited by 349 · see citing works

Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome)

Jawed, S. I., Myskowski, P. L., Horwitz, S. M., Moskowitz, A. J., & Querfeld, C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.08.033 · Cited by 346 · see citing works

Notch signaling in human development and disease

Penton, A. L., Leonard, L. D., & Spinner, N. B. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.01.010 · Cited by 332 · see citing works

Nuclear Notch1 signaling and the regulation of dendritic development

Redmond, L., Oh, S.-R., Hicks, C. D., Weinmaster, G., & Ghosh, A. (2000) · Nature Neuroscience · doi:10.1038/71104 · Cited by 313 · see citing works

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

Claudel, T., Leibowitz, M. D., Fiévet, C., Tailleux, A., Wagner, B. L., Repa, J. J., Torpier, G., Lobaccaro, J. A., Paterniti, J. R., Mangelsdorf, D. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041609298 · Cited by 292 · see citing works

Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells

Bibel, M., Richter, J., Lacroix, E., & Barde, Y.-A. (2007) · Nature Protocols · doi:10.1038/nprot.2007.147 · Cited by 283 · see citing works

The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., Walter, M., Roth, M. G., & Lazo, J. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411420200 · Cited by 279 · see citing works

Human<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice

Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274 · see citing works

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion

Koldamova, R. P., Lefterov, I. M., Ikonomovic, M. D., Skoko, J., Lefterov, P. I., Isanski, B. A., DeKosky, S. T., & Lazo, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300044200 · Cited by 237 · see citing works

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor α in Mouse Liver Reveals Extensive Sharing of Binding Sites

Boergesen, M., Pedersen, T. Å., Gross, B. S., van Heeringen, S. J., Hagenbeek, D., Bindesbøll, C., Caron, S., Lalloyer, F., Steffensen, K. R., Nebb, H. I., et al. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06175-11 · Cited by 237 · see citing works

Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease

Tang, Y., Li, T., Li, J., Yang, J., Liu, H., Zhang, X.-X., & Le, W. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.159 · Cited by 221 · see citing works

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons<i>In Vivo</i>

Dumanis, S. B., Tesoriero, J. A., Babus, L. W., Nguyen, M. T., Trotter, J. H., Ladu, M. J., Weeber, E. J., Turner, R. S., Xu, B., Rebeck, G. W., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4026-09.2009 · Cited by 220 · see citing works

Choosing a cell fate: a view from the Notch locus

Artavanis‐Tsakonas, S., & Simpson, P. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90264-q · Cited by 210 · see citing works

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice*

Donkin, J. J., Stukas, S., Hirsch-Reinshagen, V., Namjoshi, D., Wilkinson, A., May, S., Chan, J., Fan, J., Collins, J., & Wellington, C. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.108100 · Cited by 200 · see citing works

Choosing a cell fate: a view from the Notch locus

Artavanis‐Tsakonas, S. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90220-k · Cited by 199 · see citing works

Histone deacetylases in memory and cognition

Penney, J., & Tsai, L. (2014) · Science Signaling · doi:10.1126/scisignal.aaa0069 · Cited by 192 · see citing works

Possible roles of DLK1 in the Notch pathway during development and disease

Falix, F. A., Aronson, D. C., Lamers, W. H., & Gaemers, I. C. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.02.003 · Cited by 191 · see citing works

Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β

Ma, T., Chen, Y., Vingtdeux, V., Zhao, H., Viollet, B., Marambaud, P., & Klann, E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1694-14.2014 · Cited by 191 · see citing works

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., & Wisniewski, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.007 · Cited by 189 · see citing works

Epigenetic reprogramming during wound healing: loss of polycomb‐mediated silencing may enable upregulation of repair genes

Shaw, T., & Martin, P. (2009) · The EMBO Reports · doi:10.1038/embor.2009.102 · Cited by 171 · see citing works

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation

Li, Q., Zou, J., Wang, M., Ding, X., Chepelev, I., Zhou, X., Zhao, W., Wei, G., Cui, J., Zhao, K., et al. (2014) · Nature Communications · doi:10.1038/ncomms6780 · Cited by 156 · see citing works

Nuclear Receptors License Phagocytosis by Trem2⁺Myeloid Cells in Mouse Models of Alzheimer's Disease

Savage, J. C., Jay, T., Goduni, E., Quigley, C., Mariani, M. M., Malm, T., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4586-14.2015 · Cited by 154 · see citing works

Neuromantic – from Semi-Manual to Semi-Automatic Reconstruction of Neuron Morphology

Myatt, D. R., Hadlington, T., Ascoli, G. A., & Nasuto, S. J. (2012) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2012.00004 · Cited by 153 · see citing works

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

Fitz, N. F., Cronican, A. A., Lefterov, I., & Koldamova, R. (2013) · Science · doi:10.1126/science.1235809 · Cited by 151 · see citing works

Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells

Sacchetti, P., Sousa, K. M., Hall, A. C., Liste, I., Steffensen, K. R., Theofilopoulos, S., Parish, C. L., Hazenberg, C. L. E., Richter, L. Ä., Hovatta, O., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.08.019 · Cited by 142 · see citing works

Comment on “ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.”

Price, A. R., Xu, G., Siemienski, Z. B., Smithson, L. A., Borchelt, D. R., Golde, T. E., & Felsenstein, K. M. (2013) · Science · doi:10.1126/science.1234089 · Cited by 138 · see citing works

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

Fitz, N. F., Cronican, A. A., Saleem, M., Fauq, A. H., Chapman, R., Lefterov, I. M., & Koldamova, R. P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1937-12.2012 · Cited by 138 · see citing works

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortexPreprint

Rodriguez, G. A., Burns, M. P., Weeber, E. J., & Rebeck, G. W. (2013) · Learning & Memory · doi:10.1101/lm.030031.112 · Cited by 134 · see citing works

Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene

Boehm-Cagan, A., & Michaelson, D. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5198-13.2014 · Cited by 134 · see citing works

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

Veeraraghavalu, K., Zhang, C., Miller, S., Hefendehl, J. K., Rajapaksha, T. W., Ulrich, J., Jucker, M., Holtzman, D. M., Tanzi, R. E., Vassar, R., et al. (2013) · Science · doi:10.1126/science.1235505 · Cited by 133 · see citing works

Adult Neurogenesis and the Future of the Rejuvenating Brain Circuits

Lepousez, G., Nissant, A., & Lledo, P. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.002 · Cited by 129 · see citing works

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”

Tesseur, I., Lo, A. C., Roberfroid, A., Dietvorst, S., Van Broeck, B., Borgers, M., Gijsen, H., Moechars, D., Mercken, M., Kemp, J., et al. (2013) · Science · doi:10.1126/science.1233937 · Cited by 128 · see citing works

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins

DeMattos, R. B., Curtiss, L. K., & Williams, D. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4206 · Cited by 123 · see citing works

Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson’s Disease

McFarland, K., Spalding, T. A., Hubbard, D. T., Ma, J., Olsson, R., & Burstein, E. S. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400100f · Cited by 119 · see citing works

A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis

Simon, R., Brylka, H., Schwegler, H., Venkataramanappa, S., Andratschke, J., Wiegreffe, C., Liu, P., Fuchs, E., Jenkins, N., Copeland, N., et al. (2012) · EMBO Journal · doi:10.1038/emboj.2012.142 · Cited by 113 · see citing works

EphA receptor signaling—Complexity and emerging themes

Miao, H., & Wang, B. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.10.013 · Cited by 108 · see citing works

Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS

Bulfone, A. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.9.1443 · Cited by 106 · see citing works

The TREES Toolbox—Probing the Basis of Axonal and Dendritic Branching

Cuntz, H., Förstner, F., Borst, A., & Häusser, M. (2011) · Neuroinformatics · doi:10.1007/s12021-010-9093-7 · Cited by 100 · see citing works

Genome-Wide Alteration of Histone H3K9 Acetylation Pattern in Mouse Offspring Prenatally Exposed to Arsenic

Cronican, A. A., Fitz, N. F., Carter, A., Saleem, M., Shiva, S., Barchowsky, A., Koldamova, R. P., Schug, J., & Lefterov, I. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053478 · Cited by 99 · see citing works

The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages

Daniel, B., Nagy, G., Hah, N., Horvath, A., Czimmerer, Z., Poliska, S., Gyuris, T., Keirsse, J., Gysemans, C., Van Ginderachter, J. A., et al. (2014) · Genes &amp; Development · doi:10.1101/gad.242685.114 · Cited by 97 · see citing works

Maintenance of GABAergic Activity by Neuregulin 1-ErbB4 in Amygdala for Fear Memory

Lu, Y., Sun, X.-D., Hou, F., Bi, L., Yin, D., Liu, F., Chen, Y., Bean, J. C., Jiao, H.-F., Liu, X., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.029 · Cited by 95 · see citing works

Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O

Shintani, T., Ihara, M., Sakuta, H., Takahashi, H., Watakabe, I., & Noda, M. (2006) · Nature Neuroscience · doi:10.1038/nn1697 · Cited by 92 · see citing works

Emx homeogenes and mouse brain development

Cecchi, C., & Boncinelli, E. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01608-8 · Cited by 88 · see citing works

Differentiation of Human Embryonic Stem Cells into Cells with Corneal Keratocyte Phenotype

Chan, A. A., Hertsenberg, A. J., Funderburgh, M. L., Mann, M. M., Du, Y., Davoli, K. A., Mich-Basso, J. D., Yang, L., & Funderburgh, J. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056831 · Cited by 77 · see citing works

Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration

Koldamova, R. P., Schug, J., Lefterova, M. I., Cronican, A. A., Fitz, N. F., Davenport, F. A., Carter, A., Castranio, E. L., & Lefterov, I. M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.005 · Cited by 74 · see citing works

Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy

Bomben, V. C., Holth, J. K., Reed, J. G., Cramer, P. E., Landreth, G. E., & Noebels, J. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.029 · Cited by 60 · see citing works

Novel roles for Nogo receptor in inflammation and disease

David, S., Fry, E. J., & López‐Vales, R. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.002 · Cited by 58 · see citing works

Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating micro RNA expression

Gao, Y., Han, Z., Li, Q., Wu, Y., Shi, X., Ai, Z., Du, J., Li, W., Guo, Z., & Zhang, Y. (2014) · FEBS Journal · doi:10.1111/febs.13173 · Cited by 57 · see citing works

Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development

Li, Q., Wang, H. Y., Chepelev, I., Zhu, Q., Wei, G., Zhao, K., & Wang, R.-F. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004524 · Cited by 54 · see citing works

Light and Electron Microscopic Immunohistochemical Detection of Bromodeoxyuridine-labeled Cells in the Brain: Different Fixation and Processing Protocols

Ngwenya, L. B., Peters, A., & Rosene, D. L. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.4a6605.2005 · Cited by 53 · see citing works

Class 3 Semaphorin Mediates Dendrite Growth in Adult Newborn Neurons through Cdk5/FAK Pathway

Ng, T., Ryu, J. R., Sohn, J. H., Tan, T., Song, H., Ming, G., & Goh, E. L. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065572 · Cited by 53 · see citing works

Computational knowledge integration in biopharmaceutical research

Ficenec, D. (2003) · Briefings in Bioinformatics · doi:10.1093/bib/4.3.260 · Cited by 41 · see citing works

Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro

Tapias, V., Greenamyre, J. T., & Watkins, S. C. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.018 · Cited by 38 · see citing works

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

Lefterov, I. M., Schug, J., Mounier, A., Nam, K. N., Fitz, N. F., & Koldamova, R. P. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.05.019 · Cited by 36 · see citing works

Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture

Hussain, A., Luong, M., Pooley, A., & Nathan, B. P. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-49 · Cited by 34 · see citing works

Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex

Cooper, M. A., & Koleske, A. J. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23615 · Cited by 29 · see citing works

A Rapid and Sensitive Automated Image‐Based Approach for In Vitro and In Vivo Characterization of Cell Morphology and Quantification of Cell Number and Neurite Architecture

Tapias, V., & Greenamyre, J. T. (2014) · Current Protocols in Cytometry · doi:10.1002/0471142956.cy1233s68 · Cited by 19 · see citing works

Pollination Decline in Context—Response

Tylianakis, J. M. (2013) · Science · doi:10.1126/science.340.6135.924-a · Cited by 17 · see citing works

Nuclear receptors in stem cells and their therapeutic potential

Sun, G., & Shi, Y. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.003 · Cited by 16 · see citing works

Nogo-66 receptor activation inhibits neurite outgrowth and increases β-amyloid protein secretion of cortical neurons

Luo, H. (2011) · Molecular Medicine Reports · doi:10.3892/mmr.2011.692 · Cited by 15 · see citing works

TAp63γ Demethylation Regulates Protein Stability and Cellular Distribution during Neural Stem Cell Differentiation

Fonseca, M. B., Nunes, A. F., Morgado, A. L., Solá, S., & Rodrigues, C. M. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052417 · Cited by 12 · see citing works

Noncoding RNAs and the control of hormonal signaling via nuclear receptor regulation

Ottaviani, S., de Giorgio, A., Harding, V., Stebbing, J., & Castellano, L. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0134 · Cited by 10 · see citing works

Proteomic identification of differentially expressed genes during differentiation of cynomolgus monkey (Macaca fascicularis) embryonic stem cells to astrocyte progenitor cells in vitro

Akama, K., Horikoshi, T., Nakayama, T., Otsu, M., Imaizumi, N., Nakamura, M., Toda, T., Inuma, M., Hirano, H., Kondo, Y., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.12.002 · Cited by 3 · see citing works

The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer’s Disease and Other Neurodegenerative Disorders

Wójtowicz, S., Strosznajder, A. K., Jeżyna, M. J., & Strosznajder, J. B. (2020) · Neurochemical Research · doi:10.1007/s11064-020-02993-5 · Cited by 325 · see citing works

Apolipoprotein E in lipid metabolism and neurodegenerative disease

Yang, L. G., March, Z. M., Stephenson, R. A., & Narayan, P. S. (2023) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2023.05.002 · Cited by 286 · see citing works

Cancer evolution: Darwin and beyond

Vendramin, R., Litchfield, K., & Swanton, C. (2021) · The EMBO Journal · doi:10.15252/embj.2021108389 · Cited by 253 · see citing works

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

Banerjee, G., Carare, R. O., Cordonnier, C., Greenberg, S. M., Schneider, J. A., Smith, E. E., van Buchem, M. A., van der Grond, J., Verbeek, M. M., & Werring, D. J. (2017) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314697 · Cited by 242 · see citing works

ApoE Lipidation as a therapeutic target in Alzheimer’s disease

Lanfranco, M. F., Ng, C. A., & Rebeck, G. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176336 · Cited by 189 · see citing works

The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

Wolfe, C. M., Fitz, N. F., Nam, K. N., Lefterov, I. M., & Koldamova, R. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010081 · Cited by 192 · see citing works

LXR Regulation of Brain Cholesterol: From Development to Disease

Courtney, R., & Landreth, G. E. (2016) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2016.03.018 · Cited by 176 · see citing works

The long non-coding RNA Neat1 is an important mediator of the therapeutic effect of bexarotene on traumatic brain injury in mice

Zhong, J., Jiang, L., Huang, Z., Zhang, H., Cheng, C., Liu, H., He, J., Wu, J., Darwazeh, R., Wu, Y., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.001 · Cited by 108 · see citing works

Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats

Zuo, Y., Huang, L., Enkhjargal, B., Xu, W., Ocak, U., Travis, Z. D., Zhang, G., Tang, J., Liu, F., & Zhang, J. H. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1432-5 · Cited by 101 · see citing works

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

Mariani, M. M., Malm, T., Lamb, R., Jay, T. R., Neilson, L., Casali, B., Medarametla, L., & Landreth, G. E. (2017) · Scientific Reports · doi:10.1038/srep42270 · Cited by 98 · see citing works

Therapeutic potential of nuclear receptor agonists in Alzheimer's disease

Moutinho, M., & Landreth, G. E. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075556 · Cited by 75 · see citing works

Mitochondrial abnormalities in neurodegenerative models and possible interventions: Focus on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease

Pantiya, P., Thonusin, C., Chattipakorn, N., & Chattipakorn, S. C. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.08.003 · Cited by 66 · see citing works

Bexarotene modulates retinoid-X-receptor expression and is protective against neurotoxic endoplasmic reticulum stress response and apoptotic pathway activation

Dheer, Y., Chitranshi, N., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S. L., & Gupta, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1041-9 · Cited by 63 · see citing works

A randomized controlled study to evaluate the effect of bexarotene on amyloid‐β and apolipoprotein E metabolism in healthy subjects

Ghosal, K., Haag, M., Verghese, P. B., West, T., Veenstra, T., Braunstein, J. B., Bateman, R. J., Holtzman, D. M., & Landreth, G. E. (2016) · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions · doi:10.1016/j.trci.2016.06.001 · Cited by 73 · see citing works

Peripheral versus central nervous system APOE in Alzheimer’s disease: Interplay across the blood-brain barrier

Chernick, D., Ortiz‐Valle, S., Jeong, A., Qu, W., & Li, L. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134306 · Cited by 61 · see citing works

Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease

Casali, B. T., & Reed-Geaghan, E. G. (2021) · Cells · doi:10.3390/cells10040957 · Cited by 64 · see citing works

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

Burris, T. P., de Vera, I. M. S., Côté, I., Flaveny, C. A., Wanninayake, U. S., Chatterjee, A., Walker, J. K., Steinauer, N., Zhang, J., Coons, L. A., et al. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000436 · Cited by 53 · see citing works

Therapeutic targeting of nuclear receptors, liver X and retinoid X receptors, for Alzheimer's disease

Fitz, N. F., Nam, K. N., Koldamova, R. P., & Lefterov, I. M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14668 · Cited by 50 · see citing works

Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells

Fanaee‐Danesh, E., Gali, C. C., Tadić, J., Zandl‐Lang, M., Kober, A. C., Agujetas, V. R., de Dios, C., Tam‐Amersdorfer, C., Stracke, A., Albrecher, N. M., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.04.019 · Cited by 52 · see citing works

Alzheimer’s Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α

Sáez-Orellana, F., Octave, J., & Pierrot, N. (2020) · Cells · doi:10.3390/cells9051215 · Cited by 45 · see citing works

RXR heterodimers orchestrate transcriptional control of neurogenesis and cell fate specification

Simándi, Z., Horváth, A., Cuaranta‐Monroy, I., Sauer, S., Deleuze, J., & Nagy, L. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.07.033 · Cited by 37 · see citing works

Focus on 1,25-Dihydroxyvitamin D3 in the Peripheral Nervous System

Faye, P.-A., Poumeaud, F., Miressi, F., Lia, A., Demiot, C., Magy, L., Favreau, F. D., & Sturtz, F. G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00348 · Cited by 37 · see citing works

Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease

Muñoz-Cabrera, J. M., Sandoval-Hernández, A. G., Niño, A., Báez, T., Bustos-Rangel, A., Cardona‐Gómez, G. P., Múnera, A., & Arboleda, G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0223578 · Cited by 38 · see citing works

Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease

Sweet, R. A., MacDonald, M. L., Kirkwood, C. M., Ding, Y., Schempf, T. A., Jones-Laughner, J., Kofler, J., Ikonomović, M. D., López, O. L., Garver, M. E., et al. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.056580 · Cited by 35 · see citing works

Bexarotene promotes microglia/macrophages - Specific brain - Derived Neurotrophic factor expression and axon sprouting after traumatic brain injury

He, J., Huang, Y., Liu, H., Sun, X., Wu, J., Zhang, Z., Liu, L., Zhou, C., Jiang, S., Huang, Z., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113462 · Cited by 36 · see citing works

RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers

Nam, K. N., Mounier, A., Fitz, N. F., Wolfe, C. M., Schug, J., Lefterov, I. M., & Koldamova, R. P. (2016) · Scientific Reports · doi:10.1038/srep24048 · Cited by 36 · see citing works

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice

Dheer, Y., Chitranshi, N., Gupta, V. B., Sharma, S., Pushpitha, K., Abbasi, M., Mirzaei, M., You, Y., Graham, S. L., & Gupta, V. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.01.015 · Cited by 35 · see citing works

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy

Huuskonen, M. T., Loppi, S. H., Dhungana, H., Keksa-Goldsteine, V., Lemarchant, S., Korhonen, P., Wojciechowski, S., Pollari, E., Valonen, P. K., Koponen, J., et al. (2016) · Scientific Reports · doi:10.1038/srep33176 · Cited by 34 · see citing works

Nuclear receptors in neural stem/progenitor cell homeostasis

Gkikas, D., Tsampoula, M., & Politis, P. K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2571-4 · Cited by 32 · see citing works

Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers

Wang, W., Nakashima, K., Hirai, T., & Inoue, M. (2019) · Journal of Natural Medicines · doi:10.1007/s11418-018-01277-1 · Cited by 24 · see citing works

Computational capacity of pyramidal neurons in the cerebral cortex

Георгиев, Д., Kolev, S. K., Cohen, E., & Glazebrook, J. F. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147069 · Cited by 28 · see citing works

Sex-regulated gene dosage effect of PPARα on synaptic plasticity

Pierrot, N., Ris, L., Stancu, I., Doshina, A., Ribeiro, F., Tyteca, D., Baugé, E., Lalloyer, F., Malong, L., Schakman, O., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201800262 · Cited by 27 · see citing works

The novel function of bexarotene for neurological diseases

Liu, Y., Wang, P., Jin, G., Shi, P., Zhao, Y., Guo, J., Yin, Y., Shao, Q.-H., Li, P., & Yang, P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102021 · Cited by 28 · see citing works

Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice

Carter, A. Y., Letronne, F., Fitz, N. F., Mounier, A., Wolfe, C. M., Nam, K. N., Reeves, V. L., Kamboh, H., Lefterov, I. M., & Koldamova, R. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172161 · Cited by 25 · see citing works

Modulation of mitochondrial respiration underpins neuronal differentiation enhanced by lutein

Xie, K., Ngo, S., Rong, J., & Sheppard, A. M. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.243713 · Cited by 23 · see citing works

Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment

Koch, K., Schlüppmann, K., Hüsken, S., Stark, L. M., Förster, N., Masjosthusmann, S., Klose, J., Dönmez, A., & Fritsche, E. (2025) · Environment International · doi:10.1016/j.envint.2025.109400 · Cited by 21 · see citing works

Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation

Girardi, C. S., Rostirolla, D. C., Lini, F. J. M., Brum, P. O., Delgado, J., Ribeiro, C. T., Teixeira, A. A., Peixoto, D. O., Heimfarth, L., Kunzler, A., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.11.014 · Cited by 21 · see citing works

Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson’s disease-specific hepatocytes

Song, D., Takahashi, G., Zheng, Y., Matsuo‐Takasaki, M., Li, J., Takami, M., An, Y., Hemmi, Y., Miharada, N., Fujioka, T., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac080 · Cited by 19 · see citing works

Neuroprotective effect of naturally occurring RXR agonists isolated from Sophora tonkinensis Gagnep. on amyloid-β-induced cytotoxicity in PC12 cells

Wang, W., Nakashima, K., Hirai, T., & Inoue, M. (2018) · Journal of Natural Medicines · doi:10.1007/s11418-018-1257-z · Cited by 17 · see citing works

Genome-wide alteration of histone methylation profiles associated with cognitive changes in response to developmental arsenic exposure in mice

Fitz, N. F., Barchowsky, A., Koldamova, R. P., & Lefterov, I. M. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.03.008 · Cited by 16 · see citing works

Preserving and enhancing mitochondrial function after stroke to protect and repair the neurovascular unit: novel opportunities for nanoparticle-based drug delivery

Novorolsky, R. J., Kasheke, G. D. S., Hakim, A. M., Földvári, M., Dorighello, G. G., Sekler, I., Vuligonda, V., Sanders, M. E., Renden, R., Wilson, J. J., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1226630 · Cited by 17 · see citing works

Bexarotene attenuates early brain injury via inhibiting micoglia activation through PPARγ after experimental subarachnoid hemorrhage

Tu, L., Yang, X., Zhang, Q., Wang, Q., Tian, T., Liu, D., Qu, X., & Tian, J. (2018) · Neurological Research · doi:10.1080/01616412.2018.1463900 · Cited by 16 · see citing works

Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes

Kamp, F., Scheidt, H. A., Winkler, E., Basset, G., Heinel, H., Hutchison, J. M. S., LaPointe, L. M., Sanders, C. R., Steiner, H., & Huster, D. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00068 · Cited by 15 · see citing works

High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis

Gao, X.-L., Tian, W., Liu, B., Wu, J., Xie, W., & Shen, Q. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010616 · Cited by 14 · see citing works

Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes

Komai, M., Noda, Y., Ikeda, A., Kaneshiro, N., Kamikubo, Y., Sakurai, T., Uehara, T., & Takasugi, N. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100510 · Cited by 13 · see citing works

CD38 is Required for Dendritic Organization in Visual Cortex and Hippocampus

Nelissen, T. P., Bamford, R. A., Tochitani, S., Akkus, K., Kudzinskas, A., Yokoi, K., Okamoto, H., Yamamoto, Y., Burbach, J. P. H., Matsuzaki, H., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.050 · Cited by 12 · see citing works

Correction to: Neuroprotective effect of naturally occurring RXR agonists isolated from Sophora tonkinensis Gagnep. on amyloid-β-induced cytotoxicity in PC12 cells

Wang, W., Nakashima, K., Hirai, T., & Inoue, M. (2019) · Journal of Natural Medicines · doi:10.1007/s11418-019-01305-8 · Cited by 14 · see citing works

Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol

Spanos, F., Gereñu, G., Goikolea, J., Latorre‐Leal, M., Balleza‐Tapia, H., Gomez, K., Álvarez-Jiménez, L., Piras, A., Gómez‐Galán, M., Fisahn, A., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1347535 · Cited by 11 · see citing works

Targeting Oligodendrocyte Dynamics and Remyelination: Emerging Therapies and Personalized Approaches in Multiple Sclerosis Management

Sharma, T., Mehan, S., Tiwari, A., Khan, Z., Gupta, G. D., & Narula, A. S. (2024) · Current Neurovascular Research · doi:10.2174/0115672026336440240822063430 · Cited by 9 · see citing works

Bexarotene drives the self‐renewing proliferation of adult neural stem cells, promotes neuron‐glial fate shift, and regulates late neuronal differentiation

Girardi, C. S., Scheibel, I. M., Santos¹, L. F. D. S., Bittencourt, R. R., Fröhlich, N. T., Possa, L. D. R., Moreira, J. C. F., & Gelain, D. P. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15998 · Cited by 8 · see citing works

Type II nuclear receptors with potential role in Alzheimer disease

Muñoz-Cabrera, J., Adrián, S.-H., & Arboleda, G. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100940 · Cited by 7 · see citing works

Suppression of amyloid-β fibril growth by drug-engineered polymorph transformation

Mafimoghaddam, S., Xu, Y., Sherman, M. B., Orlova, E. V., Karki, P., Orman, M. A., & Vekilov, P. G. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102662 · Cited by 4 · see citing works

Molluscan RXR Transcriptional Regulation by Retinoids in a Drosophila CNS Organ Culture System

de Hoog, E., Echezarreta, V. E. S., Turgambayeva, A., Foran, G., Megaly, M., Necakov, A., & Spencer, G. E. (2022) · Cells · doi:10.3390/cells11162493 · Cited by 4 · see citing works

Bexarotene Promotes Neuroblastoma SH-SY5Y Cell Differentiation to Mature Neurons with Decreased Proliferation

Zhang, F., Gao, K., Zhang, J., Li, S., Li, Y., Wang, J., Wu, Y., Jiang, Y., & Wu, C. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04888-4 · Cited by 3 · see citing works

RXR-Mediated Remodeling of Transcriptional and Chromatin Landscapes in APP Mouse Brain: Insights from Integrated Single-Cell RNA and ATAC Profiling

Yi, L., Wang, X., Girardi, C. S., Fitz, N. F., Koldamova, R. P., & Lefterov, I. M. (2025) · Cells · doi:10.3390/cells14241970 · Cited by 3 · see citing works

Dual Anti-inflammatory Actions of a Novel Retinoid X Receptor Agonist Derived from a Natural Compound in Microglial Cells

Tomita, K., Nakashima, K., Yamaguchi, E., Itoh, A., & Inoue, M. (2025) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b25-00037 · Cited by 2 · see citing works

Brain Single-Cell Transcriptional Responses to Bexarotene-Activated RXR in an Alzheimer’s Disease Model

Girardi, C. S., Yi, L., Fitz, N. F., Gelain, D. P., Lefterov, I. M., & Koldamova, R. P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052435 · Cited by 2 · see citing works

Lipidated APOE has effects on cognitive function that are independent of amyloid-β pathology

Corona, A. W., & Landreth, G. E. (2015) · Brain · doi:10.1093/brain/awv300

Effect of liver x receptor target genes Apolipoprotein E and ATP-binding cassette transporter A1 on beta-amyloid dependent pathology in Alzheimer's disease model mice

Carter, A. B. (2017) · D-Scholarship@Pitt (University of Pittsburgh)

Evidence that an HDAC2-targeted ASO persistently upregulates cortical acetylcholine and dopamine signaling via a CREB | Gs positive feedback loopPreprint

Sanders, T. H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.24.312264

Comparative evaluation of the biological characteristics of a novel retinoid X receptor agonist and bexarotene

Tomita, K., Nakashima, K., Yamaguchi, E., Itoh, A., Tsutsumiuchi, K., & Inoue, M. (2025) · Molecular Pharmacology · doi:10.1016/j.molpha.2025.100057

Decoding the effects of Bexarotene treatment on brain of AD‐like model mice: single‐cell transcriptomics and chromatin accessibility analysis

Lu, Y., Wang, X., Girardi, C. S., Fitz, N. F., Koldamova, R., & Lefterov, I. (2025) · Alzheimer s & Dementia · doi:10.1002/alz70855_103001

Signalling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos

Cardoso, D. L., Loizou, M., Fourla, D. D., Woodman, C., Guille, M., & Sharpe, C. R. (2026) · Biology Open · doi:10.1242/bio.062675

Nose-to-brain delivery of IRX4204 by cell-adhesion peptide-functionalized gemini surfactant-phospholipid nanoparticles

Hakim, A., Kasheke, G. D. S., Robertson, G. S., & Földvári, M. (2026) · RSC Pharmaceutics · doi:10.1039/d6pm00414h

RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomers

Nam, K. N., Mounier, A., Fitz, N. F., Wolfe, C. M., Schug, J., Lefterov, I. M., & Koldamova, R. P. (2016) · Scientific Reports · doi:10.1038/srep24048 · Cited by 36 · see citing works

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

Mariani, M. M., Malm, T., Lamb, R., Jay, T. R., Neilson, L., Casali, B., Medarametla, L., & Landreth, G. E. (2017) · Scientific Reports · doi:10.1038/srep42270 · Cited by 98 · see citing works

Brain Single-Cell Transcriptional Responses to Bexarotene-Activated RXR in an Alzheimer’s Disease Model

Girardi, C. S., Yi, L., Fitz, N. F., Gelain, D. P., Lefterov, I. M., & Koldamova, R. P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052435 · Cited by 2 · see citing works

Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene

Boehm-Cagan, A., & Michaelson, D. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5198-13.2014 · Cited by 134 · see citing works

Bexarotene modulates retinoid-X-receptor expression and is protective against neurotoxic endoplasmic reticulum stress response and apoptotic pathway activation

Dheer, Y., Chitranshi, N., Gupta, V., Abbasi, M., Mirzaei, M., You, Y., Chung, R., Graham, S. L., & Gupta, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1041-9 · Cited by 63 · see citing works