The DOI matches its Crossref record; 192 of the 193 references it cites were found in a registry or an index.
An overview of molecular basis of iron metabolism regulation and the associated pathologies
Open accessAbstract
Iron is essential for several vital biological processes. Its deficiency or overload drives to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, such as the alternative splicing, microRNAs, the IRP/IRE system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.
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“Furthermore, the hypoxia inducible factor (HIF) and the nuclear factor-erythroid 2-related factor 2 (NRF2) pathways are related with anemia (Lee et al., 2004;Silva and Faustino, 2015).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Silva and Faustino, 2015
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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
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The interaction between ferroptosis and inflammatory signaling pathways
Chen, Y., Fang, Z., Yi, X., Wei, X., & Jiang, D. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05716-0 · Cited by 626
Iron and cancer: recent insights
Manz, D. H., Blanchette, N. L., Paul, B. T., Torti, F. M., & Torti, S. V. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13008 · Cited by 507
Advances in pathogenesis and therapeutic strategies for osteoporosis
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On Iron Metabolism and Its Regulation
Vogt, A. S., Arsiwala, T., Mohsen, M. O., Vogel, M., Manolova, V., & Bachmann, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094591 · Cited by 505
Metadata
- Authors
- Silva, B., & Faustino, P.
- Affiliations
- National Institute of Health Dr. Ricardo Jorge (PT)
- Corresponding author
- Faustino, Paula
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 1852
- Issue
- 7
- Pages
- 1347-1359
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2076768785
- Cited by
- 300
- References
- 193
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 27 · 2023: 40 · 2022: 25 · 2021: 31 · 2020: 24 · 2019: 30 · 2018: 23 · 2017: 21 · 2016: 28 · 2015: 9
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Funders
- Fundação para a Ciência e a Tecnologia
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron metabolism, iron homeostasis, hepcidin, iron absorption, enterocytes, inflammation, anemia, erythropoiesis, post-transcriptional regulation, alternative splicing, microRNA, proteolytic cleavage
- MeSH terms
- Animals, Humans, Iron, Iron Metabolism Disorders, Iron-Binding Proteins, Iron-Regulatory Proteins
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