MicroRNAs: small RNAs with a big role in gene regulation

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation

Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works

Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes

Emery, J. F., Floyd, S. K., Alvarez, J., Eshed, Y., Hawker, N. P., Izhaki, A., Baum, S. F., & Bowman, J. L. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.035 · Cited by 1,143 · see citing works

A microRNA array reveals extensive regulation of microRNAs during brain development

KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040 · see citing works

Silencing of microRNAs in vivo with ‘antagomirs’

Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works

Epigenetics in cancer

Sharma, S., Kelly, T. K., & Jones, P. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp220 · Cited by 2,637 · see citing works

miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082 · see citing works

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010 · see citing works

A brain-specific microRNA regulates dendritic spine development

Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works

Modulation of miR-155 and miR-125b Levels following Lipopolysaccharide/TNF-α Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock

Tili, E., Michaille, J.-J., Cimino, A., Costinean, S., Dumitru, C. D., Adair, B., Fabbri, M., Alder, H., Liu, C. G., Calin, G. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5082 · Cited by 1,304 · see citing works

High-throughput functional genomics using CRISPR-Cas9

Shalem, O., Sanjana, N. E., & Zhang, F. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3899 · Cited by 1,233 · see citing works

Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA

Zhang, L., Hou, D., Chen, X., Li, D., Zhu, L., Zhang, Y., Li, J., Bian, Z., Liang, X., Cai, X., et al. (2012) · Cell Research · doi:10.1038/cr.2011.158 · Cited by 1,216 · see citing works

MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis

Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science · doi:10.1126/science.1189123 · Cited by 957 · see citing works

MEF2: a central regulator of diverse developmental programs

Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834 · see citing works

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

Okugawa, Y., Grady, W. M., & Goel, A. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.011 · Cited by 782 · see citing works

Epigenetic gene silencing in cancer: the DNA hypermethylome

Esteller, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm018 · Cited by 725 · see citing works

Regulation of miRNA expression during neural cell specification

Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03978.x · Cited by 707 · see citing works

MicroRNAs as regulatory elements in immune system logic

Mehta, A., & Baltimore, D. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.40 · Cited by 704 · see citing works

Repression of α-synuclein expression and toxicity by microRNA-7

Junn, E., Lee, K.-W., Jeong, B. S., Chan, T. W., Im, J.-Y., & Mouradian, M. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906277106 · Cited by 634 · see citing works

Identifying miRNAs, targets and functions

Liu, B., Li, J., & Cairns, M. J. (2014) · Briefings in Bioinformatics · doi:10.1093/bib/bbs075 · Cited by 563 · see citing works

Iron and cancer: recent insights

Manz, D. H., Blanchette, N. L., Paul, B. T., Torti, F. M., & Torti, S. V. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13008 · Cited by 507 · see citing works

MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation

Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.01.005 · Cited by 523 · see citing works

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging · doi:10.18632/aging.100042 · Cited by 500 · see citing works

From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

Bagni, C., & Greenough, W. T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1667 · Cited by 475 · see citing works

MicroRNA expression in the adult mouse central nervous system

Bak, M., Silahtaroglu, A., Møller, M., Christensen, M., Rath, M. F., Skryabin, B., Tommerup, N., & Kauppinen, S. (2008) · RNA · doi:10.1261/rna.783108 · Cited by 463 · see citing works

The epigenetics of aging and neurodegeneration

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works

The miRNA-Processing Enzyme Dicer Is Essential for the Morphogenesis and Maintenance of Hair Follicles

Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359 · see citing works

An alternative mode of microRNA target recognition

Chi, S. W., Hannon, G. J., & Darnell, R. B. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2230 · Cited by 328 · see citing works

Epigenetics of endometriosis

Guo, S.-W. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap064 · Cited by 328 · see citing works

miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment

Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3582 · Cited by 308 · see citing works

An overview of molecular basis of iron metabolism regulation and the associated pathologies

Silva, B., & Faustino, P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.011 · Cited by 300 · see citing works

MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway

Yang, X., Liang, L., Zhang, X.-F., Jia, H.-L., Qin, Y., Zhu, X.-C., Gao, X.-M., Qiao, P., Zheng, Y., Sheng, Y.-Y., et al. (2013) · Hepatology · doi:10.1002/hep.26305 · Cited by 280 · see citing works

Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain

He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277 · see citing works

MirSNP, a database of polymorphisms altering miRNA target sites, identifies miRNA-related SNPs in GWAS SNPs and eQTLs

Liu, C., Zhang, F., Li, T., Lu, M., Wang, L., Yue, W., & Zhang, D. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-661 · Cited by 264 · see citing works

Role of microRNAs in diabetes and its cardiovascular complications

Shantikumar, S., Caporali, A., & Emanueli, C. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvr300 · Cited by 263 · see citing works

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

Abdelmohsen, K., Srikantan, S., Kuwano, Y., & Gorospe, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809376106 · Cited by 230 · see citing works

Diabetic gastrointestinal motility disorders and the role of enteric nervous system: Current status and future directions

Yarandi, S. S., & Srinivasan, S. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12330 · Cited by 236 · see citing works

Single-cell transcriptome sequencing: recent advances and remaining challenges

Liu, S., & Trapnell, C. (2016) · F1000Research · doi:10.12688/f1000research.7223.1 · Cited by 230 · see citing works

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. (2016) · eLife · doi:10.7554/elife.18648 · Cited by 213 · see citing works

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Lopez, J. P., Fiori, L. M., Cruceanu, C., Lin, R., Labonte, B., Cates, H. M., Heller, E. A., Vialou, V., Ku, S. M., Gerald, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15497 · Cited by 201 · see citing works

MicroRNAs: novel regulators in skin inflammation

Sonkoly, E., Ståhle, M., & Pivarcsi, A. (2008) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2008.02804.x · Cited by 194 · see citing works

Role of MYC in medulloblastoma

Roussel, M. F., & Robinson, G. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014308 · Cited by 180 · see citing works

MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration

Li, D., Li, X. I., Wang, A., Meisgen, F., Pivarcsi, A., Sonkoly, E., Ståhle, M., & Landén, N. X. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.48 · Cited by 167 · see citing works

MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy

Patterson, E. E., Holloway, A. K., Weng, J., Fojo, T., & Kebebew, E. (2011) · Cancer · doi:10.1002/cncr.25724 · Cited by 171 · see citing works

3D RNA and Functional Interactions from Evolutionary Couplings

Weinreb, C., Riesselman, A. J., Ingraham, J. B., Gross, T., Sander, C., & Marks, D. S. (2016) · Cell · doi:10.1016/j.cell.2016.03.030 · Cited by 159 · see citing works

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

Zeng, C., Hou, X., Yan, J., Zhang, C., Li, W., Zhao, W., Du, S., & Dong, Y. (2020) · Advanced Materials · doi:10.1002/adma.202004452 · Cited by 152 · see citing works

miRNATissueAtlas2: an update to the human miRNA tissue atlas

Keller, A., Gröger, L., Tschernig, T., Solomon, J., Laham, O., Schaum, N., Wagner, V., Kern, F., Schmartz, G. P., Li, Y., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab808 · Cited by 143 · see citing works

MiR‐205 silences MED1 in hypoxic primary human trophoblasts

Mouillet, J., Chu, T., Nelson, D. M., Mishima, T., & Sadovsky, Y. (2010) · The FASEB Journal · doi:10.1096/fj.09-149724 · Cited by 125 · see citing works

A mouse tissue atlas of small noncoding RNA

Isakova, A., Fehlmann, T., Keller, A., & Quake, S. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002277117 · Cited by 119 · see citing works

The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory

Sim, S.-E., Lim, C.-S., Kim, J.-I., Seo, D., Chun, H., Yu, N.-K., Lee, J., Kang, S. J., Ko, H.-G., Choi, J.-H., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0630-16.2016 · Cited by 116 · see citing works

miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells

Kuhn, S., Johnson, S. L., Furness, D. N., Chen, J., Ingham, N., Hilton, J. M., Steffes, G., Lewis, M. A., Zampini, V., Hackney, C. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016646108 · Cited by 114 · see citing works

Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response

Lopez, J. P., Kos, A., & Turecki, G. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000379 · Cited by 108 · see citing works

Differential Content of Proteins, mRNAs, and miRNAs Suggests that MDSC and Their Exosomes May Mediate Distinct Immune Suppressive Functions

Geis-Asteggiante, L., Belew, A. T., Clements, V. K., Edwards, N. J., Ostrand-Rosenberg, S., El-Sayed, N. M., & Fenselau, C. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00646 · Cited by 104 · see citing works

Evidence for epigenetic regulation of pro-inflammatory cytokines, interleukin-12 and interferon gamma, in peripheral blood mononuclear cells from PTSD patients

Bam, M., Yang, X., Zhou, J., Ginsberg, J. P., Leyden, Q., Nagarkatti, P. S., & Nagarkatti, M. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9643-8 · Cited by 103 · see citing works

DNA Methylation, Genomic Silencing, and Links to Nutrition and Cancer

McCabe, D. C., & Caudill, M. A. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00136.x · Cited by 78 · see citing works

Hydrogel-based cardiac repair and regeneration function in the treatment of myocardial infarction

Xu, Q., Xiao, Z., Yang, Q., Yu, T., Deng, X., Chen, N., Huang, Y., Wang, L., Guo, J., & Wang, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100978 · Cited by 77 · see citing works

Micro <scp>RNA</scp> ‐1258 suppresses tumour progression via <scp>GRB</scp> 2/Ras/Erk pathway in non‐small‐cell lung cancer

Jiang, W., Wei, K., Pan, C., Li, H., Cao, J., Han, X., Tang, Y., Zhu, S., Yuan, W., He, Y., et al. (2018) · Cell Proliferation · doi:10.1111/cpr.12502 · Cited by 67 · see citing works

Synaptosomes secrete and uptake functionally active micro<scp>RNA</scp>s via exocytosis and endocytosis pathways

Xu, J., Chen, Q., Zen, K., Zhang, C., & Zhang, Q. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12057 · Cited by 61 · see citing works

Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease

Leggio, L., Paternò, G., Vivarelli, S., Falzone, G. G., Giachino, C., Marchetti, B., & Iraci, N. (2021) · Aging and disease · doi:10.14336/ad.2021.0527 · Cited by 55 · see citing works

Analysis of miRNA expression profiles in breast cancer using biclustering

Fiannaca, A., La Rosa, M., La Paglia, L., Rizzo, R., & Urso, A. (2015) · BMC Bioinformatics · doi:10.1186/1471-2105-16-s4-s7 · Cited by 45 · see citing works

Lost in translation: regulation of skeletal muscle protein synthesis

Weigl, L. G. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.02.017 · Cited by 44 · see citing works

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection

Johnston, D. G. W., Kearney, J., Zasłona, Z., Williams, M. A., O'Neill, L. A. J., & Corr, S. C. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00201 · Cited by 44 · see citing works

Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure

Segaran, R. C., Chan, L. Y., Wang, H., Sethi, G., & Tang, F. R. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200121122910 · Cited by 42 · see citing works

MicroRNA-145 Induces the Senescence of Activated Hepatic Stellate Cells through the Activation of P53 Pathway by ZEB2

Yang, J., Lu, Y., Yang, P., Chen, Q., Wang, Y., Ding, Q., Xu, T., Li, X., Li, C., Huang, C., et al. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27521 · Cited by 40 · see citing works

The emerging functions of the p53-miRNA network in stem cell biology

Lin, C.-P., Choi, Y. J., Hicks, G. G., & He, L. (2012) · Cell Cycle · doi:10.4161/cc.20207 · Cited by 38 · see citing works

Circulating Level of miR-378 Predicts Left Ventricular Hypertrophy in Patients with Aortic Stenosis

Chen, Z., Li, C., Xu, Y., Li, Y., Yang, H., & Rao, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105702 · Cited by 36 · see citing works

A Tumor-specific MicroRNA Recognition System Facilitates the Accurate Targeting to Tumor Cells by Magnetic Nanoparticles

Yu, Y., Yao, Y., Yan, H., Wang, R., Zhang, Z., Sun, X., Zhao, L., Ao, X., Xie, Z., & Wu, Q. (2016) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2016.28 · Cited by 31 · see citing works

Involved microRNAs in alternative polyadenylation intervene in breast cancer via regulation of cleavage factor “CFIm25”

Tamaddon, M., Shokri, G., Hosseini Rad, S. M. A., Rad, I., Emami Razavi, À., & Kouhkan, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-68406-3 · Cited by 25 · see citing works

Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning

Boschen, K. E., Keller, S. M., Roth, T. L., & Klintsova, A. Y. (2018) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2017.12.009 · Cited by 24 · see citing works

MicroRNAs in schizophrenia: implications for synaptic plasticity and dopamine–glutamate interaction at the postsynaptic density. New avenues for antipsychotic treatment under a theranostic perspective

de Bartolomeis, A., Iasevoli, F., Tomasetti, C., & Buonaguro, E. F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8962-8 · Cited by 21 · see citing works

MicroRNA-593-5p contributes to cell death following exposure to 1-methyl-4-phenylpyridinium by targeting PTEN-induced putative kinase 1

Yoo, M., Choi, D. C., Murphy, A., Ahsan, A. M., & Junn, E. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104709 · Cited by 6 · see citing works

Palmitoylation modification of SPI1 promotes nasopharyngeal carcinoma radioresistance through inhibiting c-CBL-mediated ubiquitination and degradation

Jiang, L., Bin, Y., Huang, Y., Wu, L., Qiu, X., Du, Y., Mi, J., Liu, K., Deng, Y., Ning, J., et al. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101374