Cited by 300Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

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An overview of molecular basis of iron metabolism regulation and the associated pathologies

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Silva, Bruno, Faustino, Paula·2015·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/j.bbadis.2015.03.011

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Abstract

Iron is essential for several vital biological processes. Its deficiency or overload drives to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These processes are mainly controlled by hepcidin, a liver-derived hormone which synthesis is regulated by iron levels, inflammation, infection, anemia and erythropoiesis. Besides the systemic regulation of iron metabolism mediated by hepcidin, cellular regulatory processes also occur. Cells are able to regulate themselves the expression of the iron metabolism-related genes through different post-transcriptional mechanisms, such as the alternative splicing, microRNAs, the IRP/IRE system and the proteolytic cleavage. Whenever those mechanisms are disturbed, due to genetic or environmental factors, iron homeostasis is disrupted and iron related pathologies may arise.

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Authors: Silva, B., & Faustino, P.
Affiliations: National Institute of Health Dr. Ricardo Jorge (PT)
Corresponding author: Faustino, Paula
ORCID: Silva, Bruno
Faustino, Paula
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 2015-07
Volume: 1852
Issue: 7
Pages: 1347-1359
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/j.bbadis.2015.03.011
OpenAlex: W2076768785
Cited by: 300
References: 193
Citations by year: 2026: 17 · 2025: 24 · 2024: 27 · 2023: 40 · 2022: 25 · 2021: 31 · 2020: 24 · 2019: 30 · 2018: 23 · 2017: 21 · 2016: 28 · 2015: 9
FWCI: 4.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
Funders: Fundação para a Ciência e a Tecnologia
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: iron metabolism, iron homeostasis, hepcidin, iron absorption, enterocytes, inflammation, anemia, erythropoiesis, post-transcriptional regulation, alternative splicing, microRNA, proteolytic cleavage
MeSH terms: Animals, Humans, Iron, Iron Metabolism Disorders, Iron-Binding Proteins, Iron-Regulatory Proteins

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An overview of molecular basis of iron metabolism regulation and the associated pathologies

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