The DOI matches its Crossref record; 190 of the 194 references it cites were found in a registry or an index.
Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging
Abstract
Acute contractile activity of skeletal muscle initiates the activation of signaling kinases. This promotes the phosphorylation of transcription factors, leading to enhanced DNA binding and transcriptional activation and/or repression. The mRNA products of nuclear genes encoding mitochondrial proteins are translated in the cytosol and imported into pre-existing mitochondria. When contractile activity is repeated, the recapitulation of these cellular events progressively leads to an expansion of the mitochondrial reticulum within muscle. This has physiologically relevant health benefit, including enhanced lipid metabolism and reduced muscle fatigability. In aging skeletal muscle, the response to contractile activity appears to be attenuated, suggesting that a greater contractile stimulus is required to attain a similar phenotype adaptation. This review summarizes our current understanding of the effects of exercise on the gene expression pathway leading to organelle biogenesis in muscle.
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“Key in orchestrating this process is the nuclear-encoded mitochondrial transcription factor A (TFAM), which is pivotal in regulating mtDNA transcription by directly interacting with mitochondrial genome along with mitochondrial transcription specificity factors TFB1M and TFB2M (Figure 3; Gleyzer et al., 2005; Ljubicic et al., 2010).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Ljubicic et al., 2010
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Sergi, D., Naumovski, N., Heilbronn, L. K., Abeywardena, M., O’Callaghan, N., Lionetti, L., & Luscombe-Marsh, N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00532 · Cited by 347
Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle
Powers, S. K., Talbert, E. E., & Adhihetty, P. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201327 · Cited by 349
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Metadata
- Authors
- Ljubicic, V., Joseph, A.-M., Saleem, A., Uguccioni, G., Collu-Marchese, M., Lai, R. Y. J., Nguyen, L. M.-D., & Hood, D. A.
- Affiliations
- York University (CA)
- Corresponding author
- Hood, David A.
- Venue
- Biochimica et Biophysica Acta (BBA) - General Subjects
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 1800
- Issue
- 3
- Pages
- 223-234
- ISSN
- 0304-4165 (ISSN-L)
- OpenAlex
- W2069587958
- Cited by
- 167
- References
- 194
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 16 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 21
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- mitochondrial biogenesis, skeletal muscle, physical activity, aging, transcriptional regulation, post-transcriptional regulation, mitochondrial translation, mitochondrial protein import, transcription factors, lipid metabolism, muscle fatigue, mitochondrial reticulum
- MeSH terms
- Adenosine Triphosphate, Adult, Aged, Aging, Organelle Biogenesis, Calcium, Gene Expression Regulation, Humans, Middle Aged, Mitochondria, Muscle, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription Factors, Transcription, Genetic, Protein Biosynthesis, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal
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