Cited by 167Mitochondrial Function and PathologyAdipose Tissue and MetabolismMuscle Physiology and Disorders

The DOI matches its Crossref record; 190 of the 194 references it cites were found in a registry or an index.

Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging

Ljubicic, Vladimir, Joseph, Anna-Maria, Saleem, Ayesha, Uguccioni, Giulia, Collu-Marchese, Melania, Lai, Ruanne Y.J., Nguyen, Linda M.-D., Hood, David A.·2010·Biochimica et Biophysica Acta (BBA) - General Subjects

Abstract

Acute contractile activity of skeletal muscle initiates the activation of signaling kinases. This promotes the phosphorylation of transcription factors, leading to enhanced DNA binding and transcriptional activation and/or repression. The mRNA products of nuclear genes encoding mitochondrial proteins are translated in the cytosol and imported into pre-existing mitochondria. When contractile activity is repeated, the recapitulation of these cellular events progressively leads to an expansion of the mitochondrial reticulum within muscle. This has physiologically relevant health benefit, including enhanced lipid metabolism and reduced muscle fatigability. In aging skeletal muscle, the response to contractile activity appears to be attenuated, suggesting that a greater contractile stimulus is required to attain a similar phenotype adaptation. This review summarizes our current understanding of the effects of exercise on the gene expression pathway leading to organelle biogenesis in muscle.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.bbagen.2009.07.031

Cites

190 of 190 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 194 references

Cited by

Sorted by citations

Metadata

Authors
Ljubicic, V., Joseph, A.-M., Saleem, A., Uguccioni, G., Collu-Marchese, M., Lai, R. Y. J., Nguyen, L. M.-D., & Hood, D. A.
Affiliations
York University (CA)
Corresponding author
Hood, David A.
Venue
Biochimica et Biophysica Acta (BBA) - General Subjects
Publisher
Elsevier BV
Published
2010-03
Volume
1800
Issue
3
Pages
223-234
ISSN
0304-4165 (ISSN-L)
OpenAlex
W2069587958
Cited by
167
References
194
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 16 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 14 · 2014: 13 · 2013: 11 · 2012: 21
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - General Subjects (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
mitochondrial biogenesis, skeletal muscle, physical activity, aging, transcriptional regulation, post-transcriptional regulation, mitochondrial translation, mitochondrial protein import, transcription factors, lipid metabolism, muscle fatigue, mitochondrial reticulum
MeSH terms
Adenosine Triphosphate, Adult, Aged, Aging, Organelle Biogenesis, Calcium, Gene Expression Regulation, Humans, Middle Aged, Mitochondria, Muscle, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription Factors, Transcription, Genetic, Protein Biosynthesis, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review