Cited by 242Adipose Tissue and MetabolismMetabolism, Diabetes, and CancerMitochondrial Function and Pathology

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus

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Hesselink, Matthijs K. C., Schrauwen-Hinderling, Vera, Schrauwen, Patrick·2016·Nature Reviews Endocrinology

Abstract

Low levels of physical activity and the presence of obesity are associated with mitochondrial dysfunction. In addition, mitochondrial dysfunction has been associated with the development of insulin resistance and type 2 diabetes mellitus (T2DM). Although the evidence for a causal relationship between mitochondrial function and insulin resistance is still weak, emerging evidence indicates that boosting mitochondrial function might be beneficial to patient health. Exercise training is probably the most recognized promoter of mitochondrial function and insulin sensitivity and hence is still regarded as the best strategy to prevent and treat T2DM. Animal data, however, have revealed several new insights into the regulation of mitochondrial metabolism, and novel targets for interventions to boost mitochondrial function have emerged. Importantly, many of these targets seem to be regulated by factors such as nutrition, ambient temperature and circadian rhythms, which provides a basis for nonpharmacological strategies to prevent or treat T2DM in humans. Here, we will review the current evidence that mitochondrial function can be targeted therapeutically to improve insulin sensitivity and to prevent T2DM, focusing mainly on human intervention studies.

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Crossref · 10.1038/nrendo.2016.104

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Authors
Hesselink, M. K. C., Schrauwen-Hinderling, V., & Schrauwen, P.
Affiliations
Maastricht University Medical Centre (NL)
Corresponding author
Schrauwen, Patrick
Venue
Nature Reviews Endocrinology
Published
2016-07-22
Volume
12
Issue
11
Pages
633-645
ISSN
  • 1759-5029 (ISSN-L)
  • 1759-5037
OpenAlex
W2502246205
Cited by
242
References
162
Citations by year
2026: 10 · 2025: 18 · 2024: 17 · 2023: 25 · 2022: 23 · 2021: 24 · 2020: 34 · 2019: 27 · 2018: 34 · 2017: 26 · 2016: 3 · 2013: 1
FWCI
3.55
Type
journal article
Language
en
Locations
  • Nature Reviews Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, other-oa)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
type 2 diabetes, skeletal muscle mitochondria, mitochondrial dysfunction, insulin resistance, insulin sensitivity, exercise training, non-pharmacological treatment, nutrition, ambient temperature, circadian rhythm, obesity, mitochondrial metabolism, therapeutic target
MeSH terms
Carnitine, Circadian Rhythm, Diabetes Mellitus, Type 2, Diet Therapy, Exercise Therapy, Humans, Insulin Resistance, Mitochondria, Muscle, Obesity, Sleep, Temperature, Exercise, Cryotherapy, Muscle, Skeletal, Dietary Supplements, Caloric Restriction

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